Microwave Spectroscopy of Myocardial Ischemia and Infarction. 2. Biophysical Reconstruction

AbstractThe proposed dielectrical relaxation model of the myocardium in the microwave spectrum has been verified both on test solutions and on normal canine myocardium. Furthermore, the model was utilized to reconstruct the changes in tissue properties (including myocardial bulk resistance and water content) following myocardial acute ischemia and chronic infarction. It was shown that the reconstructed myocardial resistance and water content correlate dynamically with the process of the development of acute myocardial ischemic injury. In chronic cases the reconstructed resistance and water content of infarcted myocardium are significantly different from that of normal myocardium: the resistance is lower and water content is higher than in normal myocardium. © 2000 Biomedical Engineering Society. PAC00: 8764-t, 8719Xx

[1]  R J Sheppard,et al.  Dielectric behaviour of biological molecules in solution , 1978 .

[2]  S.Y. Semenov,et al.  Microwave tomography: two-dimensional system for biological imaging , 1996, IEEE Transactions on Biomedical Engineering.

[3]  K. Foster,et al.  Dielectric properties of tissues and biological materials: a critical review. , 1989, Critical reviews in biomedical engineering.

[4]  K R Foster,et al.  Myocardial Electrical Impedance Mapping of Ischemic Sheep Hearts and Healing Aneurysms , 1993, Circulation.

[5]  Bradley J. Roth,et al.  The electrical potential produced by a strand of cardiac muscle: A bidomain analysis , 2006, Annals of Biomedical Engineering.

[6]  M. Nakazawa,et al.  Ischemic changes in myocardial ionic contents of the isolated perfused rat hearts as studied by NMR , 1993, Molecular and Cellular Biochemistry.

[7]  G. Aksnes.  Why do ischemic and hypoxic myocardium lose potassium? , 1992, Journal of molecular and cellular cardiology.

[8]  A. Kleber,et al.  Effect of Oxygen Withdrawal on Active and Passive Electrical Properties of Arterially: Perfused Rabbit Ventricular Muscle , 1989, Circulation research.

[9]  R. Jennings,et al.  Development of cell injury in sustained acute ischemia. , 1990, Circulation.

[10]  Robert H. Svenson,et al.  Microwave Spectroscopy of Myocardial Ischemia and Infarction. 1. Experimental Study , 2004, Annals of Biomedical Engineering.

[11]  Elijah Polak,et al.  Computational methods in optimization , 1971 .

[12]  Devendra K. Misra,et al.  Static analysis of an open-ended coaxial line terminated by layered media , 1990 .

[13]  D. Skorton,et al.  NMR relaxation times in acute myocardial infarction: Relative influence of changes in tissue water and fat content , 1992, Magnetic resonance in medicine.

[14]  P. Steendijk,et al.  Dependence of anisotropic myocardial electrical resistivity on cardiac phase and excitation frequency , 1994, Basic Research in Cardiology.

[15]  M. Kushmerick,et al.  Ionic Mobility in Muscle Cells , 1969, Science.

[16]  A. Kleber,et al.  Electrical uncoupling and increase of extracellular resistance after induction of ischemia in isolated, arterially perfused rabbit papillary muscle. , 1987, Circulation research.

[17]  R C Barr,et al.  Electric field stimulation of excitable tissue. , 1998, IEEE transactions on bio-medical engineering.

[18]  Robert H. Svenson,et al.  Dielectric properties of canine acute and chronic myocardial infarction at a cell relaxation spectrum. II. Theory , 1997, Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136).

[19]  J. L. Hill,et al.  Effect of Acute Coronary Artery Occlusion on Local Myocardial Extracellular K+ Activity in Swine , 1980, Circulation.

[20]  Jan Venselaar,et al.  DESIGN RULES , 1999 .

[21]  D. Hearse.  Cardioplegia: the protection of the myocardium during open heart surgery: a review. , 1980, Journal de physiologie.

[22]  S. Stuchly,et al.  Numerical Analysis of Open-Ended Coaxial Lines , 1983 .

[23]  Hearse Dj.  Cardioplegia: the protection of the myocardium during open heart surgery: a review. , 1980 .