Acetaminophen-induced differentiation of human breast cancer stem cells and inhibition of tumor xenograft growth in mice.

[1]  B. Martín-Castillo,et al.  Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status , 2010, Cell cycle.

[2]  Louis Vermeulen,et al.  Wnt activity defines colon cancer stem cells and is regulated by the microenvironment , 2010, Nature Cell Biology.

[3]  Wolfram Goessling,et al.  The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML , 2010, Science.

[4]  M. Otsuka,et al.  Low direct cytotoxicity of loxoprofen on gastric mucosal cells. , 2010, Biological & pharmaceutical bulletin.

[5]  K. Struhl,et al.  Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. , 2009, Cancer research.

[6]  David A Hess,et al.  High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability , 2009, Journal of cellular and molecular medicine.

[7]  Eric S. Lander,et al.  Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening , 2009, Cell.

[8]  M. Wicha,et al.  Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling , 2009, PLoS biology.

[9]  T. Mizushima,et al.  Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells. , 2009, Biological & pharmaceutical bulletin.

[10]  Jenny C. Chang,et al.  Treatment Resistance in Stem Cells and Breast Cancer , 2009, Journal of Mammary Gland Biology and Neoplasia.

[11]  M. Dean.  ABC Transporters, Drug Resistance, and Cancer Stem Cells , 2009, Journal of Mammary Gland Biology and Neoplasia.

[12]  J. Visvader,et al.  Cancer stem cells in solid tumours: accumulating evidence and unresolved questions , 2008, Nature Reviews Cancer.

[13]  B. Alman,et al.  Side population cells in human cancers. , 2008, Cancer letters.

[14]  O. De Wever,et al.  Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers. , 2008, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[15]  Wenjun Guo,et al.  The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells , 2008, Cell.

[16]  Susan G Hilsenbeck,et al.  Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. , 2008, Journal of the National Cancer Institute.

[17]  G. Mills,et al.  Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. , 2008, Cancer research.

[18]  R. Nusse.  Wnt signaling and stem cell control , 2008, Cell Research.

[19]  M. Duncan,et al.  Attenuation of junctional adhesion molecule-A is a contributing factor for breast cancer cell invasion. , 2008, Cancer research.

[20]  Kay Brune,et al.  Acetaminophen (paracetamol) is a selective cyclooxygenase‐2 inhibitor in man , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[21]  J. Lieberman,et al.  let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells , 2007, Cell.

[22]  D. Birnbaum,et al.  ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. , 2007, Cell stem cell.

[23]  Michael F Clarke,et al.  The biology of cancer stem cells. , 2007, Annual review of cell and developmental biology.

[24]  L. Zon,et al.  Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis , 2007, Nature.

[25]  Riccardo Fodde,et al.  Wnt/β-catenin signaling in cancer stemness and malignant behavior , 2007 .

[26]  R. Beroukhim,et al.  Molecular definition of breast tumor heterogeneity. , 2007, Cancer cell.

[27]  M. Clarke,et al.  Identification of pancreatic cancer stem cells. , 2007, Cancer research.

[28]  L. Ricci-Vitiani,et al.  Identification and expansion of human colon-cancer-initiating cells , 2007, Nature.

[29]  Frank Pajonk,et al.  The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. , 2006, Journal of the National Cancer Institute.

[30]  Harikrishna Nakshatri,et al.  CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis , 2006, Breast Cancer Research.

[31]  Scott E. Martin,et al.  Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer. , 2006, Cancer research.

[32]  N. Maitland,et al.  Prospective identification of tumorigenic prostate cancer stem cells. , 2005, Cancer research.

[33]  Maria-José U. Ferreira,et al.  The effects of jatrophane derivatives on the reversion of MDR1- and MRP-mediated multidrug resistance in the MDA-MB-231 (HTB-26) cell line. , 2005, Anticancer research.

[34]  Thomas Kirchner,et al.  Migrating cancer stem cells — an integrated concept of malignant tumour progression , 2005, Nature Reviews Cancer.

[35]  Danila Coradini,et al.  Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. , 2005, Cancer research.

[36]  P. Johnston,et al.  The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites , 2005, Molecular Cancer Therapeutics.

[37]  Keisuke Ito,et al.  Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche , 2004, Cell.

[38]  K. Brennan,et al.  Wnt Proteins in Mammary Development and Cancer , 2004, Journal of Mammary Gland Biology and Neoplasia.

[39]  Bob Y. Liu,et al.  The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[40]  H. Varmus,et al.  Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[41]  L. James,et al.  Acetaminophen-induced hepatotoxicity. , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[42]  Cynthia Hawkins,et al.  Identification of a cancer stem cell in human brain tumors. , 2003, Cancer research.

[43]  G. Dontu,et al.  In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. , 2003, Genes & development.

[44]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[45]  R. Botting,et al.  Actions of paracetamol on cyclooxygenases in tissue and cell homogenates of mouse and rabbit. , 2002, Medical science monitor : international medical journal of experimental and clinical research.

[46]  T. Golub,et al.  Genome-wide views of cancer. , 2001, The New England journal of medicine.

[47]  M. Kool,et al.  A family of drug transporters: the multidrug resistance-associated proteins. , 2000, Journal of the National Cancer Institute.

[48]  D. Keppler,et al.  Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. , 1999, Molecular pharmacology.

[49]  O. Legrand,et al.  Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients. , 1998, Blood.

[50]  J. Dick,et al.  Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell , 1997, Nature Medicine.

[51]  P. Polster,et al.  Antipyretic analgesics inhibit prostaglandin release from astrocytes and macrophages similarly. , 1986, European journal of pharmacology.

[52]  C. Klaassen,et al.  Comparison of the effects of sodium sulfate and N-acetylcysteine on the hepatotoxicity of acetaminophen in mice. , 1986, The Journal of pharmacology and experimental therapeutics.

[53]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[54]  J. Vane,et al.  Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol) , 1972, Nature.

[55]  P. Greengard,et al.  Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor , 2004, Nature Medicine.