Nonspecific and selective stimulation of the immune system in the treatment of carcinoma in humans.

The experience of the Toronto General Hospital in the use of nonspecific stimulation of the immune system with bacille Calmette-Guérin (BCG) for the treatment of cancer of the gastrointestinal tract, malignant melanoma and breast cancer is described. The results are presented in terms of survival curves. The use of BCG administered intraperitoneally in a randomized study of patients with gastric, pancreatic and colorectal cancer proved of no benefit. On the other hand, when BCG was given orally in a randomized study of patients with resectable cancer of the colon and in nonrandomized consecutive studies of patients with malignant melanoma and stage IV carcinoma of the breast survival was increased. In a group of patients with advanced gastrointestinal cancer selective stimulation of the immune system with NED 137 produced a significant increase in survival when compared with the survival of historical controls (the patients given BCG intraperitoneally along with 5-fluorouracil for gastrointestinal cancer). The results of these studies suggest the need for a more rational approach in manipulating the immune response that would combine chemotherapy with selective stimulation of the immune system.

[1]  A. Chow,et al.  Empyema caused by Clostridium perfringens. , 1983, Canadian Medical Association journal.

[2]  L. Rotstein,et al.  Comparison of the antitumor effects of a synthetic biopolymer and standard adjuvants. , 1980, Surgery.

[3]  L. Rotstein,et al.  Mechanism of increased antitumor immunity by a synthetic polymer. , 1980, Journal of Surgical Research.

[4]  A. Howell,et al.  Intravascular haemolysis and renal impairment after blood transfusion in two patients on long-term 5-fluorouracil and mitomycin-C. , 1980, The Lancet.

[5]  L. Makowka,et al.  Modulation of the immune response and control of tumour spread by a new synthetic compound , 1979, The British journal of surgery.

[6]  M. Glaser.  Augmentation of specific immune response against a syngeneic SV40-induced sarcoma in mice by depletion of suppressor T cells with cyclophosphamide. , 1979, Cellular immunology.

[7]  T. File,et al.  Pneumonia and empyema caused by Clostridium sordellii. , 1977, The American journal of the medical sciences.

[8]  M. Mckneally,et al.  INTRAPLEURAL B.C.G. IMMUNOSTIMULATION IN LUNG CANCER , 1977, The Lancet.

[9]  M. Pike,et al.  Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. , 1977, British Journal of Cancer.

[10]  E. Hersh,et al.  BCG Vaccine and Its Derivatives: Potential, Practical Considerations, and Precautions in Human Cancer Immunotherapy , 1976 .

[11]  A. Chow,et al.  Necrotizing pneumonia and empyema due to Clostridium perfringens. Report of a case and review of the literature. , 1975, The American journal of medicine.

[12]  J. Bartlett,et al.  Bacteriology of empyema. , 1974, Lancet.

[13]  G. Hill,et al.  Experimental effects of hyperbaric oxgen on selected clostridial species. I. In-vitro studies. , 1972, The Journal of infectious diseases.