The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domain

[1]  J. Thorner,et al.  The STE2 gene product is the ligand-binding component of the alpha-factor receptor of Saccharomyces cerevisiae. , 1988, The Journal of biological chemistry.

[2]  T. Jessell,et al.  Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. , 1988, Science.

[3]  M. Caron,et al.  Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. , 1988, Science.

[4]  S. Reed,et al.  Mutations in a gene encoding the alpha subunit of a Saccharomyces cerevisiae G protein indicate a role in mating pheromone signaling , 1988, Molecular and cellular biology.

[5]  M. Caron,et al.  Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization , 1988, Nature.

[6]  D. Baker,et al.  Protein transport to the vacuole and receptor-mediated endocytosis by clathrin heavy chain-deficient yeast , 1988, The Journal of cell biology.

[7]  D. Lowy,et al.  Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. , 1988, Science.

[8]  C. Strader,et al.  Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor. , 1988, Biochemistry.

[9]  J. Kurjan,et al.  Pheromonal regulation and sequence of the Saccharomyces cerevisiae SST2 gene: a model for desensitization to pheromone. , 1987, Molecular and cellular biology.

[10]  E. W. Jones,et al.  Protease B of the lysosomelike vacuole of the yeast Saccharomyces cerevisiae is homologous to the subtilisin family of serine proteases , 1987, Molecular and cellular biology.

[11]  J L Benovic,et al.  Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[12]  C. Strader,et al.  Structural features required for ligand binding to the beta‐adrenergic receptor. , 1987, The EMBO journal.

[13]  M. Caron,et al.  Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. , 1987, Science.

[14]  F. McCormick,et al.  A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. , 1987, Science.

[15]  K. Arai,et al.  GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction , 1987, Cell.

[16]  D. Shore,et al.  Transcriptional regulation in the yeast life cycle. , 1987, Science.

[17]  Nancy Kleckner,et al.  A Method for Gene Disruption That Allows Repeated Use of URA3 Selection in the Construction of Multiply Disrupted Yeast Strains , 1987, Genetics.

[18]  G. Sprague,,et al.  Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae , 1987, Molecular and cellular biology.

[19]  G. Fink,et al.  Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein , 1987, Molecular and cellular biology.

[20]  C. Strader,et al.  The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration , 1987, Cell.

[21]  D. Sibley,et al.  Regulation of transmembrane signaling by receptor phosphorylation , 1987, Cell.

[22]  The yeast SCG1 gene: a G alpha-like protein implicated in the a- and alpha-factor response pathway. , 1987, Cell.

[23]  D. Botstein,et al.  A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. , 1987, Gene.

[24]  S. Nakanishi,et al.  cDNA eloping of bovine substance-K receptor through oocyte expression system , 1987, Nature.

[25]  A. Gilman,et al.  G proteins: transducers of receptor-generated signals. , 1987, Annual review of biochemistry.

[26]  M. Mishina,et al.  Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor , 1986, Nature.

[27]  G. Fink,et al.  Saccharomyces cerevisiae nuclear fusion requires prior activation by alpha factor , 1986, Molecular and cellular biology.

[28]  M. Kwatra,et al.  Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist. , 1986, The Journal of biological chemistry.

[29]  D. Jenness,et al.  Down regulation of the α-factor pheromone receptor in S. cerevisiae , 1986, Cell.

[30]  H. Riezman,et al.  Two yeast mutants defective in endocytosis are defective in pheromone response , 1986, Cell.

[31]  Paul Greengard,et al.  Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization , 1986, Nature.

[32]  G. Saari,et al.  Multiple regulation of STE2, a mating-type-specific gene of Saccharomyces cerevisiae , 1986, Molecular and cellular biology.

[33]  M. Caron,et al.  Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Brian K. Kobilka,et al.  Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin , 1986, Nature.

[35]  J. Nathans,et al.  Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. , 1986, Science.

[36]  G. Sprague,,et al.  Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[37]  S. W. Hall,et al.  Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[38]  L. Hartwell,et al.  Binding of alpha-factor pheromone to Saccharomyces cerevisiae a cells: dissociation constant and number of binding sites , 1986, Molecular and cellular biology.

[39]  G. Fink,et al.  Laboratory course manual for methods in yeast genetics , 1986 .

[40]  L. Stryer,et al.  G proteins: a family of signal transducers. , 1986, Annual review of cell biology.

[41]  K. Struhl.  Nucleotide sequence and transcriptional mapping of the yeast pet56-his3-ded1 gene region. , 1985, Nucleic acids research.

[42]  K. Arai,et al.  Nucleotide sequences of STE2 and STE3, cell type‐specific sterile genes from Saccharomyces cerevisiae , 1985, The EMBO journal.

[43]  David R. Sibley,et al.  Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model , 1985, Nature.

[44]  E. Chen,et al.  Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. , 1985, DNA.

[45]  E. Chen,et al.  Supercoil sequencing: a fast method for sequencing plasmid DNA , 1985 .

[46]  L. Hartwell,et al.  The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene. , 1985, Nucleic acids research.

[47]  J. Nathans,et al.  Isolation and nucleotide sequence of the gene encoding human rhodopsin. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[48]  P. Schimmel,et al.  Yeast LEU2. Repression of mRNA levels by leucine and primary structure of the gene product. , 1984, The Journal of biological chemistry.

[49]  J. Thorner,et al.  Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor , 1984, Cell.

[50]  D. Botstein,et al.  Structure and function of the yeast URA3 gene: expression in Escherichia coli. , 1984, Gene.

[51]  J. Thorner,et al.  Molecular cloning of hormone-responsive genes from the yeast Saccharomyces cerevisiae. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[52]  S. A. Moore,et al.  Yeast cells recover from mating pheromone alpha factor-induced division arrest by desensitization in the absence of alpha factor destruction. , 1984, The Journal of biological chemistry.

[53]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[54]  K. Murata,et al.  Transformation of intact yeast cells treated with alkali cations. , 1984, Journal of bacteriology.

[55]  J. Thorner,et al.  Extracellular suppression allows mating by pheromone-deficient sterile mutants of Saccharomyces cerevisiae , 1983, Journal of bacteriology.

[56]  J. Thorner,et al.  Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase , 1983, Cell.

[57]  I. Herskowitz,et al.  Control of yeast cell type by the mating type locus: Positive regulation of the α-specific STE3 gene by the MATα 1 product , 1983, Cell.

[58]  K. Murata,et al.  Transformation of intact yeast cells treated with alkali cations , 1983 .

[59]  L. Hartwell,et al.  Binding of alpha-factor pheromone to yeast a cells: chemical and genetic evidence for an alpha-factor receptor. , 1983, Cell.

[60]  T. Hunter,et al.  Detection and quantification of phosphotyrosine in proteins. , 1983, Methods in enzymology.

[61]  R. Rothstein.  One-step gene disruption in yeast. , 1983, Methods in enzymology.

[62]  M. Lischwe,et al.  A new method for partial peptide mapping using N-chlorosuccinimide/urea and peptide silver staining in sodium dodecyl sulfate-polyacrylamide gels. , 1982, Analytical biochemistry.

[63]  D. Botstein,et al.  Lethal disruption of the yeast actin gene by integrative DNA transformation. , 1982, Science.

[64]  U Wilden,et al.  Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites. , 1982, Biochemistry.

[65]  R. K. Chan,et al.  Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones , 1982, Molecular and cellular biology.

[66]  R. K. Chan,et al.  Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones , 1982, Molecular and cellular biology.

[67]  I. Herskowitz,et al.  Control of yeast cell type by the mating type locus. I. Identification and control of expression of the a-specific gene BAR1. , 1981, Journal of molecular biology.

[68]  G. Samokhin,et al.  Independent action of α-factor and cycloheximide on the rate of cell-cycle initiation in Saccharomyces cerevisiae , 1981 .

[69]  G. Samokhin,et al.  The effect of α-factor on the rate of cell-cycle initiation in Saccharomyces cerevisiae: α-Factor modulates transition probability in yeast , 1981 .

[70]  J. Carbon,et al.  Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene. , 1980, Gene.

[71]  L. Hartwell.  Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone , 1980, The Journal of cell biology.

[72]  T. Hunter,et al.  Transforming gene product of Rous sarcoma virus phosphorylates tyrosine , 1980, Proceedings of the National Academy of Sciences.

[73]  D. Botstein,et al.  Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. , 1979, Gene.

[74]  J. Thorner,et al.  Recovery of S. cerevisiae a cells from G1 arrest by α factor pheromone requires endopeptidase action , 1979, Cell.

[75]  J. Chamberlain,et al.  Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. , 1979, Analytical biochemistry.

[76]  R. W. Davis,et al.  High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[77]  R. Somers,et al.  Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase. , 1978, The Journal of biological chemistry.

[78]  J. Thorner,et al.  Cell-Cell Recognition in Saccharomyces cerevisiae: Regulation of Mating-Specific Adhesion , 1978, Journal of bacteriology.

[79]  P. Lipke,et al.  Morphogenic effects of alpha-factor on Saccharomyces cerevisiae a cells , 1976, Journal of bacteriology.

[80]  I. Herskowitz,et al.  Evidence for a new diffusible element of mating pheromones in yeast , 1976, Nature.

[81]  E. Southern.  Detection of specific sequences among DNA fragments separated by gel electrophoresis. , 1975, Journal of molecular biology.

[82]  L. Hartwell.  Synchronization of haploid yeast cell cycles, a prelude to conjugation. , 1973, Experimental cell research.

[83]  K. E. Cooper.  Theory of Antibiotic Inhibition Zones in Agar Media , 1955, Nature.