Steven-Johnson Syndrome following Sodium Valproate Monotherapy

Steven-Johnson Syndrome (SJS) is a severe, episodic, acute mucocutaneous reaction characterized by blisters and epidermal detachment resulting from epidermal necrosis in the absence of substantial dermal inflammation. We report a case of 64-year old male farmer who developed Stevens-Johnson syndrome following the ingestion of Sodium Valproate monotherapy prescribed for seizure disorder. He was treated with intravenous corticosteroids, antihistamine, antibiotics and supportive therapy. We are presenting this case to highlight the serious adverse effect of commonly prescribed antiepileptic drug, sodium valproate as a monotherapy.