Development of a miniaturised drug delivery system with wireless power transfer and communication

The development of an implantable system designed to deliver drug doses in a controlled manner over an extended time period is reported. Key performance parameters are the physical size, the power consumption and also the ability to perform wireless communications to enable the system to be externally controlled and interrogated. The system has been designed to facilitate wireless power transfer, which is very important for miniaturisation as it removes the need for a battery.

[1]  G. Kovacs,et al.  Thermally and electrically isolated single crystal silicon structures in CMOS technology , 1994, IEEE Electron Device Letters.

[2]  M. Offenberg,et al.  Bosch deep silicon etching: improving uniformity and etch rate for advanced MEMS applications , 1999, Technical Digest. IEEE International MEMS 99 Conference. Twelfth IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.99CH36291).

[3]  K. Bean,et al.  Anisotropic etching of silicon , 1978, IEEE Transactions on Electron Devices.

[4]  Sharon Kingman Holey chips for drug delivery. , 2001, Drug discovery today.

[5]  D. Liepmann,et al.  Continuous on-chip micropumping through a microneedle , 2001, Technical Digest. MEMS 2001. 14th IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.01CH37090).

[6]  John T Santini,et al.  Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device , 2006, Nature Biotechnology.

[7]  C.E. Webb,et al.  Chip shots , 2004, IEEE Spectrum.

[8]  H. Kahn,et al.  Thin-film shape-memory alloy actuated micropumps , 1998 .

[9]  Dominiek Reynaerts,et al.  An implantable drug-delivery system based on shape memory alloy micro-actuation , 1997 .

[10]  Alan F. Murray,et al.  Implementation of a wireless power transfer and communications system for an implantable drug delivery system , 2006 .

[11]  Mauro Ferrari,et al.  Nanoengineered device for drug delivery application , 2004 .

[12]  Anthony J. Walton,et al.  Aluminium passivation for TMAH based anisotropic etching for MEMS applications , 1999 .

[13]  M. Cima,et al.  A controlled-release microchip , 1999, Nature.

[14]  K. R. Williams,et al.  Etch rates for micromachining processing-Part II , 2003 .

[15]  R. P. Frankenthal,et al.  The Anodic Corrosion of Gold in Concentrated Chloride Solutions , 1982 .

[16]  B Merchant,et al.  Gold, the noble metal and the paradoxes of its toxicology. , 1998, Biologicals : journal of the International Association of Biological Standardization.

[17]  G. Kovacs,et al.  Bulk micromachining of silicon , 1998, Proc. IEEE.

[18]  S Smith,et al.  Development of a miniaturised drug delivery system with wireless power transfer and communication. , 2006, IET nanobiotechnology.

[19]  S. Gamper,et al.  A high-performance silicon micropump for disposable drug delivery systems , 2001, Technical Digest. MEMS 2001. 14th IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.01CH37090).

[20]  U. Schnakenberg,et al.  TMAHW etchants for silicon micromachining , 1991, TRANSDUCERS '91: 1991 International Conference on Solid-State Sensors and Actuators. Digest of Technical Papers.

[21]  Rebecca S. Shawgo,et al.  Mechanical testing of gold membranes on a MEMS device for drug delivery , 2002, 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.02EX578).

[22]  M. Reim,et al.  Video fluorescein angiography: Method and clinical application , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[23]  O. Tabata,et al.  Anisotropic etching of silicon in (CH/sub 3/)/sub 4/NOH solutions , 1991, TRANSDUCERS '91: 1991 International Conference on Solid-State Sensors and Actuators. Digest of Technical Papers.

[24]  James D. Weiland,et al.  Scalable high lead-count parylene package for retinal prostheses , 2006 .

[25]  R. Engelbrecht,et al.  DIGEST of TECHNICAL PAPERS , 1959 .

[26]  John T Santini,et al.  Electrothermally activated microchips for implantable drug delivery and biosensing. , 2005, Journal of controlled release : official journal of the Controlled Release Society.