HLA-DQ8 as an Ir gene in coeliac disease

DQ8 restricted gliadin peptide is immunogenic in the intestinal mucosa of HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs, and strongly suggests that DQ2 and DQ8 act as immune response (Ir) genes in this disease

[1]  William E. Grizzle,et al.  Detection of high incidence of K-ras oncogenes during human colon tumorigenesis , 1987, Nature.

[2]  K. Lundin,et al.  T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase , 2001, European journal of immunology.

[3]  A. Bhattacharyya,et al.  Magnification chromoendoscopy for the detection of intestinal metaplasia and dysplasia in Barrett’s oesophagus , 2003, Gut.

[4]  R Ott,et al.  Biopsy surveillance is still necessary in patients with Barrett’s oesophagus despite new endoscopic imaging techniques , 2003, Gut.

[5]  B. Wilson,et al.  Autofluorescence endoscopy: feasibility of detection of GI neoplasms unapparent to white light endoscopy with an evolving technology. , 2001, Gastrointestinal endoscopy.

[6]  E. G. Hahn,et al.  Fluorescence induced with 5-aminolevulinic acid for the endoscopic detection and follow-up of esophageal lesions. , 2001, Gastrointestinal endoscopy.

[7]  A Sette,et al.  The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides , 1987, Science.

[8]  H. Mcdevitt,et al.  Histocompatibility-linked immune response genes. , 1972, Science.

[9]  F. A. Benko,et al.  Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer. , 1997, British Journal of Cancer.

[10]  B E Bouma,et al.  Diagnosis of specialized intestinal metaplasia by optical coherence tomography. , 2001, Gastroenterology.

[11]  I Itzkan,et al.  In vivo identification of colonic dysplasia using fluorescence endoscopic imaging. , 1999, Gastrointestinal endoscopy.

[12]  Dermot Kelleher,et al.  A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up , 2003, Gut.

[13]  M. Sivak,et al.  Methylene blue selectively stains intestinal metaplasia in Barrett's esophagus. , 1996, Gastrointestinal endoscopy.

[14]  J. Griffiths,et al.  Carcinoma of the colon and rectum: Circulating malignant cells and five‐year survival , 1973, Cancer.

[15]  B. Vogelstein,et al.  Prevalence of ras gene mutations in human colorectal cancers , 1987, Nature.

[16]  J. Hurley,et al.  Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. , 1985, Science.

[17]  K. Kinzler,et al.  Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. , 1992, Science.

[18]  J. Horwhat,et al.  Sky blue or murky waters: the diagnostic utility of methylene blue. , 2001, Gastrointestinal endoscopy.

[19]  E. Furth,et al.  Accuracy of EUS in the evaluation of Barrett's esophagus and high-grade dysplasia or intramucosal carcinoma. , 2001, Gastrointestinal endoscopy.

[20]  M. Sivak,et al.  Methylene blue staining of dysplastic and nondysplastic Barrett's esophagus: an in vivo and ex vivo study. , 2001, Endoscopy.

[21]  Hiroyuki Yamamoto,et al.  Classification of Barrett's epithelium by magnifying endoscopy. , 2002, Gastrointestinal endoscopy.

[22]  G. Falk,et al.  Practice patterns for surveillance of Barrett's esophagus in the united states. , 2000, Gastrointestinal endoscopy.

[23]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[24]  M. Guelrud,et al.  Enhanced magnification endoscopy: a new technique to identify specialized intestinal metaplasia in Barrett's esophagus. , 2000, Gastrointestinal endoscopy.

[25]  S. Achilefu,et al.  Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform. , 2001, Journal of biomedical optics.

[26]  L. Gossner,et al.  Photodynamic ablation of high-grade dysplasia and early cancer in Barrett's esophagus by means of 5-aminolevulinic acid. , 1998, Gastroenterology.

[27]  H. Varmus,et al.  Characteristics of cellular RNA related to the transforming gene of avian sarcoma viruses , 1978, Cell.

[28]  C. Lightdale,et al.  Combined magnification endoscopy with chromoendoscopy for the evaluation of Barrett's esophagus. , 1994, Gastrointestinal endoscopy.

[29]  P. Propping,et al.  Detection of APC and k-ras mutations in the serum of patients with colorectal cancer. , 2001, Cancer detection and prevention.

[30]  L. Sollid.  Molecular basis of celiac disease. , 2000, Annual review of immunology.

[31]  M. Ray,et al.  Comparison of methylene blue-directed biopsies and conventional biopsies in the detection of intestinal metaplasia and dysplasia in Barrett's esophagus: a preliminary study. , 2001, Gastrointestinal endoscopy.

[32]  S Auricchio,et al.  An immunodominant DQ8 restricted gliadin peptide activates small intestinal immune response in in vitro cultured mucosa from HLA-DQ8 positive but not HLA-DQ8 negative coeliac patients , 2003, Gut.

[33]  G S Kino,et al.  Micromachined scanning confocal optical microscope. , 1996, Optics letters.