Two B or not two B? Overview of the rapidly expanding B-box family of proteins.

The B-box gene family represents a large number of genes involved in functions such as axial patterning, growth control, differentiation, and transcriptional regulation. These genes possess several conserved motifs that always include a B-box zinc binding motif associated with various other motifs such as the RING zinc finger, an alpha-helical coiled-coil, the rfp or B30.2 motif, propeller domain, and the NHL motif in various combinations. Mutations or rearrangements in several B-box family members are associated with human diseases and cancers such as familial Mediterranean fever (FMF), Optiz/BBB syndrome, acute promyelocytic leukemia, mulibrey nanism, and thyroid carcinomas. This suggests that members of this gene family play important roles in fundamental biological processes. Here we discuss the known members of this rapidly expanding protein family.

[1]  Y. Masuho,et al.  Isolation of a cDNA for a novel human RING finger protein gene, RNF18, by the virtual transcribed sequence (VTS) approach(1). , 2000, Biochimica et biophysica acta.

[2]  A Orimo,et al.  Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem. , 2000, Genomics.

[3]  S. Inoue,et al.  Molecular cloning of testis-abundant finger Protein/Ring finger protein 23 (RNF23), a novel RING-B box-coiled coil-B30.2 protein on the class I region of the human MHC. , 2000, Biochemical and biophysical research communications.

[4]  B. Trueb,et al.  BSPRY, a novel protein of the Ro-Ret family. , 2000, Biochimica et biophysica acta.

[5]  A. Shearn,et al.  Mutations in the β-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brain , 2000, Oncogene.

[6]  R. Hawley,et al.  Genetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in Drosophila. , 2000, Genetics.

[7]  S. Rosengren,et al.  Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism , 2000, Nature Genetics.

[8]  A. Fire,et al.  The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans. , 1999, Genes & development.

[9]  Y. Yarden,et al.  The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor* , 1999, The Journal of Biological Chemistry.

[10]  Y. Ouchi,et al.  Molecular cloning of rat efp: expression and regulation in primary osteoblasts. , 1999, Biochemical and biophysical research communications.

[11]  A. Ballabio,et al.  Functional characterization of the Opitz syndrome gene product (midin): evidence for homodimerization and association with microtubules throughout the cell cycle. , 1999, Human molecular genetics.

[12]  A. Matera,et al.  Nuclear bodies: multifaceted subdomains of the interchromatin space. , 1999, Trends in cell biology.

[13]  H. Rabes,et al.  The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas , 1999, Oncogene.

[14]  S. Vincent,et al.  Cloning and Characterization of a Novel RING Finger Protein That Interacts with Class V Myosins* , 1999, The Journal of Biological Chemistry.

[15]  J. Downing,et al.  HERF1, a Novel Hematopoiesis-Specific RING Finger Protein, Is Required for Terminal Differentiation of Erythroid Cells , 1999, Molecular and Cellular Biology.

[16]  M. Whitlow,et al.  Protein fold analysis of the B30.2‐like domain , 1999, Proteins.

[17]  S. Inoue,et al.  Stage-specific expression of estrogen receptor subtypes and estrogen responsive finger protein in preimplantational mouse embryos. , 1999, Endocrine journal.

[18]  P. Freemont,et al.  SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation. , 1999, Journal of cell science.

[19]  E. Fearon,et al.  Siah-1 N-Terminal RING Domain Is Required for Proteolysis Function, and C-Terminal Sequences Regulate Oligomerization and Binding to Target Proteins , 1999, Molecular and Cellular Biology.

[20]  F. Slack,et al.  A novel repeat domain that is often associated with RING finger and B-box motifs. , 1998, Trends in biochemical sciences.

[21]  A. Levine,et al.  Metal and RNA binding properties of the hdm2 RING finger domain. , 1998, Biochemistry.

[22]  J. McClary,et al.  The novel estrogen-responsive B-box protein (EBBP) gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant. , 1998, Molecular endocrinology.

[23]  Y. Ouchi,et al.  Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis. , 1998, Biochemical and biophysical research communications.

[24]  P. Freemont,et al.  Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. , 1998, Journal of cell science.

[25]  J. Lacroix,et al.  XL43 and XL75: two novel RING finger-containing genes expressed during oogenesis and embryogenesis in Xenopus laevis. , 1998, Gene.

[26]  D. Frank,et al.  ncl-1 Is Required for the Regulation of Cell Size and Ribosomal RNA Synthesis in Caenorhabditis elegans , 1998, The Journal of cell biology.

[27]  L. Etkin,et al.  xnf7 functions in dorsal-ventral patterning of the Xenopus embryo. , 1997, Developmental biology.

[28]  Jacques Demaille,et al.  A candidate gene for familial Mediterranean fever , 1997, Nature Genetics.

[29]  F. Collins,et al.  Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever , 1997, Cell.

[30]  P. Freemont,et al.  Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution. , 1997, Journal of cell science.

[31]  P. Pontarotti,et al.  B30.2-like domain proteins: a growing family. , 1997, Biochemical and biophysical research communications.

[32]  R. Wolff,et al.  A 1.1-Mb transcript map of the hereditary hemochromatosis locus. , 1997, Genome research.

[33]  W. Schaffner,et al.  Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1. , 1996, Nucleic acids research.

[34]  P. Freemont,et al.  PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia. , 1996, Oncogene.

[35]  N. Asai,et al.  A RING finger motif regulates transforming activity of the rfp/ret fusion gene. , 1996, Biochemical and biophysical research communications.

[36]  A. Levine,et al.  The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain , 1996, Molecular medicine.

[37]  P. Freemont,et al.  Does this have a familiar RING? , 1996, Trends in biochemical sciences.

[38]  P. Freemont,et al.  The RING finger domain: a recent example of a sequence-structure family. , 1996, Current opinion in structural biology.

[39]  C. Wu,et al.  Finely tuned regulation of cytoplasmic retention of Xenopus nuclear factor 7 by phosphorylation of individual threonine residues , 1996, Molecular and cellular biology.

[40]  P. Freemont,et al.  In vivo and in vitro characterization of the B1 and B2 zinc-binding domains from the acute promyelocytic leukemia protooncoprotein PML. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Peirong Yang,et al.  Analysis of the Growth and Transformation Suppressor Domains of Promyelocytic Leukemia Gene, PML(*) , 1996, The Journal of Biological Chemistry.

[42]  J. Gall,et al.  A zinc-binding domain is required for targeting the maternal nuclear protein PwA33 to lampbrush chromosome loops , 1995, The Journal of cell biology.

[43]  S. Inoue,et al.  Molecular Cloning, Structure, and Expression of Mouse Estrogen-responsive Finger Protein Efp , 1995, The Journal of Biological Chemistry.

[44]  N. Mechti,et al.  Molecular Cloning of a New Interferon-induced Factor That Represses Human Immunodeficiency Virus Type 1 Long Terminal Repeat Expression (*) , 1995, The Journal of Biological Chemistry.

[45]  B. Cullen,et al.  Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins. , 1995, Virology.

[46]  P. Chambon,et al.  The N‐terminal part of TIF1, a putative mediator of the ligand‐dependent activation function (AF‐2) of nuclear receptors, is fused to B‐raf in the oncogenic protein T18. , 1995, The EMBO journal.

[47]  P. Freemont,et al.  The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto‐oncoprotein PML. , 1995, The EMBO journal.

[48]  al. et,et al.  Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B , 1995, Science.

[49]  G. Lozano,et al.  PML, a growth suppressor disrupted in acute promyelocytic leukemia , 1994, Molecular and cellular biology.

[50]  B. Pasini,et al.  Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease , 1994, Nature.

[51]  M. Kloc,et al.  Cytoplasmic retention of Xenopus nuclear factor 7 before the mid blastula transition uses a unique anchoring mechanism involving a retention domain and several phosphorylation sites , 1994, The Journal of cell biology.

[52]  Y. Ouchi,et al.  Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[53]  R. Lovering,et al.  Identification and preliminary characterization of a protein motif related to the zinc finger. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[54]  J. Gall,et al.  A putative zinc‐binding protein on lampbrush chromosome loops. , 1993, The EMBO journal.

[55]  P. Freemont,et al.  A novel zinc finger coiled-coil domain in a family of nuclear proteins. , 1992, Trends in biochemical sciences.

[56]  P. Chambon,et al.  Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins. , 1992, The EMBO journal.

[57]  L. Deaven,et al.  Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia , 1992, Molecular and cellular biology.

[58]  M. Matsuyama,et al.  The ret oncogene products are membrane-bound glycoproteins phosphorylated on tyrosine residues in vivo. , 1991, Biochemical and biophysical research communications.

[59]  L. Etkin,et al.  A unique bipartite cysteine-histidine motif defines a subfamily of potential zinc-finger proteins. , 1991, Nucleic acids research.

[60]  M. Kloc,et al.  The cloning and characterization of a maternally expressed novel zinc finger nuclear phosphoprotein (xnf7) in Xenopus laevis. , 1991, Developmental biology.

[61]  Christine Chomienne,et al.  The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR , 1991, Cell.

[62]  K. Umesono,et al.  Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML , 1991, Cell.

[63]  P. Pelicci,et al.  Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties. , 1991, Oncogene.

[64]  T. Fleming,et al.  Development of a highly efficient expression cDNA cloning system: application to oncogene isolation. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[65]  J. Trowsdale,et al.  A novel gysteine-rich sequence motif , 1991, Cell.

[66]  D. Sheer,et al.  Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. , 1990, Science.

[67]  I. Mather,et al.  Cloning and analysis of cDNA encoding bovine butyrophilin, an apical glycoprotein expressed in mammary tissue and secreted in association with the milk-fat globule membrane during lactation. , 1990, The Journal of biological chemistry.

[68]  D. Segretain,et al.  Molecular analysis of ref(2)P, a Drosophila gene implicated in sigma rhabdovirus multiplication and necessary for male fertility. , 1989, The EMBO journal.

[69]  T. Iwamoto,et al.  Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. , 1988, Oncogene.

[70]  G. Freeman,et al.  rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[71]  H. Hiai,et al.  Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene , 1988, Molecular and cellular biology.

[72]  G. Cooper,et al.  ret transforming gene encodes a fusion protein homologous to tyrosine kinases , 1987, Molecular and cellular biology.

[73]  George J. Feldman,et al.  Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22 , 1997, Nature Genetics.

[74]  C. Ponting,et al.  ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins. , 1996, Trends in biochemical sciences.

[75]  M. Handel,et al.  Mouse ret finger protein (rfp) proto-oncogene is expressed at specific stages of mouse spermatogenesis. , 1996, Developmental genetics.

[76]  E. Koonin,et al.  The chromo superfamily: new members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin. , 1995, Nucleic acids research.

[77]  D. Clayton,et al.  Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC , 1994, Nature Genetics.

[78]  Y. Hosoi,et al.  Expression of a Candidate Ataxia-telangiectasia Group D Gene in Cultured Fibroblast Cell Lines and Human Tissues. , 1994, International journal of radiation biology.

[79]  J. Buyon,et al.  Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen. , 1991, The Journal of clinical investigation.

[80]  A. Mclaren,et al.  Current problems in germ cell differentiation , 1983 .