Validation of a CFD methodology for positive displacement LVAD analysis using PIV data.

Computational fluid dynamics (CFD) is used to asses the hydrodynamic performance of a positive displacement left ventricular assist device. The computational model uses implicit large eddy simulation direct resolution of the chamber compression and modeled valve closure to reproduce the in vitro results. The computations are validated through comparisons with experimental particle image velocimetry (PIV) data. Qualitative comparisons of flow patterns, velocity fields, and wall-shear rates demonstrate a high level of agreement between the computations and experiments. Quantitatively, the PIV and CFD show similar probed velocity histories, closely matching jet velocities and comparable wall-strain rates. Overall, it has been shown that CFD can provide detailed flow field and wall-strain rate data, which is important in evaluating blood pump performance.

[1]  Steven Deutsch,et al.  Diaphragm motion affects flow patterns in an artificial heart. , 2003, Artificial organs.

[2]  Steven Deutsch,et al.  Development and Validation of a Computational Fluid Dynamics Methodology for Simulation of Pulsatile Left Ventricular Assist Devices , 2007, ASAIO journal.

[3]  G Rosenberg,et al.  In vivo testing of a completely implanted total artificial heart system. , 1993, ASAIO journal.

[4]  Shmuel Einav,et al.  Numerical model of flow in a sac-type ventricular assist device. , 2006, Artificial organs.

[5]  G Rosenberg,et al.  Fluid dynamics of a pediatric ventricular assist device. , 2000, Artificial organs.

[6]  S. Deutsch,et al.  Fluid dynamic analysis of the 50 cc Penn State artificial heart under physiological operating conditions using particle image velocimetry. , 2004, Journal of biomechanical engineering.

[7]  A. Yoganathan,et al.  Heart Valve Replacements: Problems and Developments , 1992 .

[8]  F. Shakib Finite element analysis of the compressible Euler and Navier-Stokes equations , 1989 .

[9]  Shmuel Einav,et al.  The Hemodynamics of the Berlin Pulsatile VAD and the Role of its MHV Configuration , 2006, Annals of Biomedical Engineering.

[10]  P. Lu,et al.  A reevaluation and discussion on the threshold limit for hemolysis in a turbulent shear flow. , 2001, Journal of biomechanics.

[11]  G. Hulbert,et al.  A generalized-α method for integrating the filtered Navier–Stokes equations with a stabilized finite element method , 2000 .

[12]  S. Deutsch,et al.  Off-design considerations of the 50cc Penn State Ventricular Assist Device. , 2005, Artificial organs.

[13]  W S Pierce,et al.  Pierce-Donachy pediatric VAD: progress in development. , 1996, The Annals of thoracic surgery.

[14]  J. Hubbell,et al.  Visualization and analysis of mural thrombogenesis on collagen, polyurethane and nylon. , 1986, Biomaterials.

[15]  C. Zapanta,et al.  Multiscale Surface Evaluation Of Thrombosis In Left Ventricular Assist Systems , 2003 .

[16]  James W. Kreider,et al.  The 50cc Penn State Left Ventricular Assist Device: A Parametric Study of Valve Orientation Flow Dynamics , 2006, ASAIO journal.

[17]  C S König,et al.  Flow mixing and fluid residence times in a model of a ventricular assist device. , 2001, Medical engineering & physics.

[18]  Richard B. Medvitz,et al.  Development and validation of a computational fluid dynamic methodology for pulsatile blood pump design and prediction of thrombus potential , 2008 .

[19]  J. Magovern,et al.  Bridge to heart transplantation: the Penn State experience. , 1986, The Journal of heart transplantation.

[20]  J. M. A. Stijnena,et al.  Evaluation of a fictitious domain method for predicting dynamic response of mechanical heart valves , 2004 .

[21]  D. Geselowitz,et al.  Local blood residence times in the Penn State artificial heart. , 1991, Artificial organs.

[22]  A. Snyder,et al.  Testing of a 50 cc stroke volume completely implantable artificial heart: expanding chronic mechanical circulatory support to women, adolescents, and small stature men. , 2000, ASAIO journal.

[23]  Steven Deutsch,et al.  Wall shear-rate estimation within the 50cc Penn State artificial heart using particle image velocimetry. , 2004, Journal of biomechanical engineering.

[24]  Steven Deutsch,et al.  EXPERIMENTAL FLUID MECHANICS OF PULSATILE ARTIFICIAL BLOOD PUMPS , 2006 .

[25]  J. Stijnen Interaction between the mitral and aortic heart valve : an experimental and computational study , 2004 .

[26]  D B Geselowitz,et al.  LDA measurements of mean velocity and Reynolds stress fields within an artificial heart ventricle. , 1994, Journal of biomechanical engineering.

[27]  J D Hellums,et al.  Morphological, biochemical, and functional changes in human platelets subjected to shear stress. , 1975, The Journal of laboratory and clinical medicine.

[28]  Pramote Hochareon DEVELOPMENT OF PARTICLE IMAGE VELOCIMETRY (PIV) FOR WALL SHEAR STRESS ESTIMATION WITHIN A 50CC PENN STATE ARTIFICIAL HEART VENTRICULAR CHAMBER , 2003 .