Personalized Medicine for Metastatic Prostate Cancer: The Paradigm of PARP Inhibitors.
暂无分享,去创建一个
[1] C. Redfern,et al. Rucaparib or Physician's Choice in Metastatic Prostate Cancer. , 2023, The New England journal of medicine.
[2] D. Generali,et al. DNA repair deficiency as circulating biomarker in prostate cancer , 2023, Frontiers in Oncology.
[3] N. Lawrentschuk,et al. Combination treatment in metastatic prostate cancer: is the bar too high or have we fallen short? , 2022, Nature Reviews Urology.
[4] D. Generali,et al. Combining inhibition of immune checkpoints and PARP: rationale and perspectives in cancer treatment , 2022, Expert opinion on therapeutic targets.
[5] M. Loda,et al. Randomized Trial of Olaparib With or Without Cediranib for Metastatic Castration-Resistant Prostate Cancer: The Results From National Cancer Institute 9984 , 2022, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[6] A. Bryce,et al. Emergence of BRCA Reversion Mutations in Patients with Metastatic Castration-resistant Prostate Cancer After Treatment with Rucaparib. , 2022, European urology.
[7] K. Cadoo,et al. PARP Inhibitors in Advanced Prostate Cancer in Tumors with DNA Damage Signatures , 2022, Cancers.
[8] E. Antonarakis,et al. 1362MO Pembrolizumab + olaparib vs abiraterone (abi) or enzalutamide (enza) for patients (pts) with previously treated metastatic castration-resistant prostate cancer (mCRPC): Randomized open-label phase III KEYLYNK-010 study , 2022, Annals of Oncology.
[9] C. Redfern,et al. Patient-reported outcomes with olaparib plus abiraterone versus placebo plus abiraterone for metastatic castration-resistant prostate cancer: a randomised, double-blind, phase 2 trial. , 2022, The Lancet. Oncology.
[10] M. Burotto,et al. Nivolumab plus rucaparib for metastatic castration-resistant prostate cancer: results from the phase 2 CheckMate 9KD trial , 2022, Journal for ImmunoTherapy of Cancer.
[11] G. Attard,et al. Blood-based liquid biopsies for prostate cancer: clinical opportunities and challenges , 2022, British Journal of Cancer.
[12] A. Armstrong,et al. Abiraterone and Olaparib for Metastatic Castration-Resistant Prostate Cancer. , 2022, NEJM evidence.
[13] J. Randall,et al. The Prognostic Significance of Homologous Recombination Repair Pathway Alterations in Metastatic Hormone Sensitive Prostate Cancer. , 2022, Clinical Genitourinary Cancer.
[14] N. Agarwal,et al. TALAPRO-3: A phase 3, double-blind, randomized study of enzalutamide (ENZA) plus talazoparib (TALA) versus placebo plus ENZA in patients with DDR gene–mutated, metastatic castration-sensitive prostate cancer (mCSPC). , 2022, Journal of Clinical Oncology.
[15] A. Marchetti,et al. Implementation of preventive and predictive BRCA testing in patients with breast, ovarian, pancreatic, and prostate cancer: a position paper of Italian Scientific Societies , 2022, ESMO open.
[16] L. Appleman,et al. Pembrolizumab Plus Docetaxel and Prednisone in Patients with Metastatic Castration-resistant Prostate Cancer: Long-term Results from the Phase 1b/2 KEYNOTE-365 Cohort B Study. , 2022, European urology.
[17] E. Maiello,et al. The Interplay between PARP Inhibitors and Immunotherapy in Ovarian Cancer: The Rationale behind a New Combination Therapy , 2022, International journal of molecular sciences.
[18] David C. Smith,et al. Targeting resistant prostate cancer, with or without DNA repair defects, using the combination of ceralasertib (ATR inhibitor) and olaparib (the TRAP trial). , 2022, Journal of Clinical Oncology.
[19] A. Armstrong,et al. PROpel: Phase III trial of olaparib (ola) and abiraterone (abi) versus placebo (pbo) and abi as first-line (1L) therapy for patients (pts) with metastatic castration-resistant prostate cancer (mCRPC). , 2022, Journal of Clinical Oncology.
[20] J. Carles,et al. A phase Ib, open-label study evaluating the safety and efficacy of ipatasertib + rucaparib in patients with metastatic castration-resistant prostate cancer (mCRPC). , 2022, Journal of Clinical Oncology.
[21] H. Scher,et al. Niraparib in patients with metastatic castration-resistant prostate cancer and DNA repair gene defects (GALAHAD): a multicentre, open-label, phase 2 trial. , 2022, The Lancet. Oncology.
[22] A. Lau,et al. ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib , 2022, Cancer research.
[23] A. Jemal,et al. Cancer statistics, 2022 , 2022, CA: a cancer journal for clinicians.
[24] C. Higano,et al. Response to Rucaparib in BRCA-Mutant Metastatic Castration-Resistant Prostate Cancer Identified by Genomic Testing in the TRITON2 Study , 2021, Clinical Cancer Research.
[25] F. Saad,et al. Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial. , 2021, The Lancet. Oncology.
[26] S. Pettitt,et al. Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial , 2021, Cancer discovery.
[27] K. Pantel,et al. Liquid Biopsy: From Discovery to Clinical Application. , 2021, Cancer discovery.
[28] Ronald C. Chen,et al. CASPAR (Alliance A031902): A randomized, phase III trial of enzalutamide (ENZ) with rucaparib (RUCA)/placebo (PBO) as a novel therapy in first-line metastatic castration-resistant prostate cancer (mCRPC). , 2021 .
[29] V. Conteduca,et al. New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer , 2021, Cells.
[30] H. G. van der Poel,et al. EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. , 2020, European urology.
[31] F. Saad,et al. Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer. , 2020, The New England journal of medicine.
[32] E. Antonarakis,et al. BRCA1 Versus BRCA2 and PARP Inhibitor Sensitivity in Prostate Cancer: More Different Than Alike? , 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[33] C. Higano,et al. Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration , 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[34] A. Bertaut,et al. Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment , 2020, BMC Cancer.
[35] A. Tutt,et al. Clinical BRCA1/2 reversion analysis identifies hotspot mutations and predicted neoantigens associated with therapy resistance. , 2020, Cancer discovery.
[36] C. Parker,et al. Prostate Cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. , 2020, Annals of oncology : official journal of the European Society for Medical Oncology.
[37] Anne E. Calvaresi,et al. Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019. , 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[38] I. Chirivella,et al. PROREPAIR-A: Clinical and molecular characterization study of prostate cancer (PC) patients with and without previously known germline BRCA1/2 mutations. , 2020 .
[39] F. Saad,et al. Olaparib for Metastatic Castration-Resistant Prostate Cancer. , 2020, The New England journal of medicine.
[40] F. Feng,et al. Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: Analysis From the Phase II TRITON2 Study , 2020, Clinical Cancer Research.
[41] N. Tunariu,et al. Genomics of lethal prostate cancer at diagnosis and castration resistance , 2019, The Journal of clinical investigation.
[42] N. Tunariu,et al. Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial , 2019, The Lancet. Oncology.
[43] C. Drake,et al. Pembrolizumab for Treatment-Refractory Metastatic Castration-Resistant Prostate Cancer: Multicohort, Open-Label Phase II KEYNOTE-199 Study. , 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[44] A. Sboner,et al. PARP Inhibition Suppresses GR–MYCN–CDK5–RB1–E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer , 2019, Clinical Cancer Research.
[45] J. Ledermann,et al. Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy. , 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[46] A. D'Amico,et al. Prostate Cancer, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology. , 2019, Journal of the National Comprehensive Cancer Network : JNCCN.
[47] A. Semjonow,et al. BRCAness in prostate cancer , 2019, OncoTarget.
[48] S. Fröhling,et al. Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance , 2019, Cold Spring Harbor molecular case studies.
[49] S. Ramaswamy,et al. Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models , 2019, Scientific Reports.
[50] Wei Tang,et al. Targeting NPRL2 to enhance the efficacy of Olaparib in castration-resistant prostate cancer. , 2019, Biochemical and biophysical research communications.
[51] P. Meltzer,et al. Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations , 2018, Journal of Immunotherapy for Cancer.
[52] G. Hatch,et al. HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells , 2018, Molecular oncology.
[53] G. Mills,et al. PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness. , 2018, Cancer research.
[54] James X. Sun,et al. BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma. , 2018, Cancer discovery.
[55] A. D’Andrea. Mechanisms of PARP inhibitor sensitivity and resistance. , 2018, DNA repair.
[56] F. Saad,et al. Interim results of a phase Ib study of niraparib plus androgen receptor-targeted therapy in men with metastatic castration-resistant prostate cancer. , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.
[57] P. Ott,et al. Pembrolizumab for advanced prostate adenocarcinoma: findings of the KEYNOTE-028 study , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.
[58] F. Saad,et al. Olaparib combined with abiraterone in patients with metastatic castration-resistant prostate cancer: a randomised, double-blind, placebo-controlled, phase 2 trial. , 2018, The Lancet. Oncology.
[59] A. Ashworth,et al. Synthetic lethal therapies for cancer: what’s next after PARP inhibitors? , 2018, Nature Reviews Clinical Oncology.
[60] M. Gleave,et al. Clinical and molecular features of treatment‐related neuroendocrine prostate cancer , 2018, International journal of urology : official journal of the Japanese Urological Association.
[61] A. Ashworth,et al. Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors. , 2017, Cancer discovery.
[62] A. Chinnaiyan,et al. Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition. , 2017, Cancer discovery.
[63] S. Tavaré,et al. Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer , 2017, Nature Communications.
[64] H. Wu,et al. CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair , 2017, Annals of oncology : official journal of the European Society for Medical Oncology.
[65] P. Schirmacher,et al. Guidance Statement On BRCA1/2 Tumor Testing in Ovarian Cancer Patients. , 2017, Seminars in oncology.
[66] Wenjun Chang,et al. Androgen receptor inhibitor–induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer , 2017, Science Signaling.
[67] M. Lieber,et al. Non-homologous DNA end joining and alternative pathways to double-strand break repair , 2017, Nature Reviews Molecular Cell Biology.
[68] G. Walker,et al. Mechanisms of DNA damage, repair, and mutagenesis , 2017, Environmental and molecular mutagenesis.
[69] Wei Guo,et al. BRCA2 mutations should be screened early and routinely as markers of poor prognosis: evidence from 8,988 patients with prostate cancer , 2017, Oncotarget.
[70] Alan Ashworth,et al. PARP inhibitors: Synthetic lethality in the clinic , 2017, Science.
[71] G. Hortobagyi,et al. PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression , 2017, Clinical Cancer Research.
[72] K. Jensen,et al. Tumor BRCA1 Reversion Mutation Arising during Neoadjuvant Platinum-Based Chemotherapy in Triple-Negative Breast Cancer Is Associated with Therapy Resistance , 2017, Clinical Cancer Research.
[73] J. Li,et al. Targeting Plk1 to Enhance Efficacy of Olaparib in Castration-Resistant Prostate Cancer , 2017, Molecular Cancer Therapeutics.
[74] R. Simon,et al. Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness , 2016, EMBO reports.
[75] Ahmet Zehir,et al. Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. , 2016, The New England journal of medicine.
[76] Wei Yuan,et al. DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. , 2015, The New England journal of medicine.
[77] David C. Smith,et al. Integrative Clinical Genomics of Advanced Prostate Cancer , 2015, Cell.
[78] R. Fishel,et al. Mismatch repair during homologous and homeologous recombination. , 2015, Cold Spring Harbor perspectives in biology.
[79] V. Giranda,et al. Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer , 2014, Investigational New Drugs.
[80] Y. Pommier,et al. Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib , 2013, Molecular Cancer Therapeutics.
[81] Alan Ashworth,et al. Mechanisms of resistance to therapies targeting BRCA-mutant cancers , 2013, Nature Medicine.
[82] A. Ashworth,et al. Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor , 2013, The Journal of pathology.
[83] Y. Pommier,et al. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. , 2012, Cancer research.
[84] S. Powell,et al. BRCA1 and BRCA2: different roles in a common pathway of genome protection , 2011, Nature Reviews Cancer.
[85] Rochelle L. Garcia,et al. Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[86] Y. Miki,et al. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. , 2010, Molecular cell.
[87] A. Ashworth,et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. , 2009, The New England journal of medicine.
[88] V. O'shea,et al. Base-excision repair of oxidative DNA damage , 2007, Nature.
[89] Alan Ashworth,et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy , 2005, Nature.
[90] J. Hoeijmakers. Genome maintenance mechanisms for preventing cancer , 2001, Nature.
[91] J. Nickoloff,et al. Regulation of DNA double-strand break repair pathway choice , 2008, Cell Research.
[92] Wolf-Dietrich Heyer,et al. Homologous recombination in DNA repair and DNA damage tolerance , 2008, Cell Research.