Efficacy of Octyl-2-Cyanoacrylate in Type I Tympanoplasty

Objective: To evaluate the safety and efficacy of octyl-2-cyanoacrylate for type I tympanoplasty. Methods: This study involved 23 patients (14 females and 9 males) with chronic otitis media who underwent type I tympanoplasty. During surgery, the temporal fascia is placed underlying the eardrum remnant, and octyl-2-cyanoacrylate was dropped over the temporal fascia. The mean air-bone gap (ABG) at the 4 frequencies (500, 1000, 2000, and 4000) was calculated for each patient before and after surgery. These data were compared by Student t test. Results: The mean follow-up was 10 months (range, 6-12 mo). Successful tympanic membrane grafting occurred in 21 patients (91.3%). Graft failure was seen in 2 patients. The mean preoperative ABG of the 23 patients was 19.3 (SD, 5.7) dB, and the postoperative ABG improved to a mean value of 8.2 (SD, 5.9) dB (P ≤ 0.0001). Conclusions: Octyl-2-cyanoacrylate is effective and safe in using as a compound on temporalis muscle fascia in type I tympanoplasty and can be used more widely in tympanoplasty.

[1]  C. Miki,et al.  Efficacy of dermabond for closing lymphatic leakage after resection and OK-432 treatment of a lymphangioma. , 2008, Plastic and reconstructive surgery.

[2]  L. Grimaldi,et al.  Octyl-2-Cyanoacrylate Adhesive for Skin Closure and Prevention of Infection in Plastic Surgery , 2006, Aesthetic Plastic Surgery.

[3]  P. Clarke,et al.  The use of octyl-2-cyanoacrylate (Dermabond) tissue adhesive for skin closure in head and neck surgery. , 2006, Annals of the Royal College of Surgeons of England.

[4]  P. Coulthard,et al.  Closure of long surgical incisions with a new formulation of 2-octylcyanoacrylate tissue adhesive versus commercially available methods. , 2004, American journal of surgery.

[5]  A. Gosain,et al.  The current status of tissue glues: part II. For adhesion of soft tissues. , 2002, Plastic and reconstructive surgery.

[6]  W. Eaglstein,et al.  An Octyl‐2‐Cyanoacrylate Formulation Speeds Healing of Partial‐Thickness Wounds , 2001, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[7]  A. Campbell,et al.  A single blind, prospective, randomized trial comparing n-butyl 2-cyanoacrylate tissue adhesive (Indermil) and sutures for skin closure in hand surgery. , 2001, Journal of hand surgery.

[8]  N. Bhat,et al.  Retrospective analysis of surgical outcome, symptom changes, and hearing improvement following myringoplasty. , 2000, The Journal of otolaryngology.

[9]  R. M. Bretaña,et al.  Use of N-butyl-2-cyanoacrylate in oral surgery: biological and clinical evaluation. , 2000, Artificial organs.

[10]  R. Goode,et al.  Efficacy of octyl-2-cyanoacrylate tissue glue in blepharoplasty. A prospective controlled study of wound-healing characteristics. , 1999, Archives of facial plastic surgery.

[11]  A. Nigam,et al.  The use of Indermil (n-butyl cyanoacrylate) in otorhinolaryngology and head and neck surgery. A preliminary report on the first 33 patients , 1997, The Journal of Laryngology & Otology.

[12]  I. Stiell,et al.  A randomized trial comparing octylcyanoacrylate tissue adhesive and sutures in the management of lacerations. , 1997, JAMA.

[13]  M. Gersdorff,et al.  Myringoplasty: long-term results in adults and children. , 1995, The American journal of otology.

[14]  J. Wells,et al.  Bony ossicular fixation using 2-cyano-butyl-acrylate adhesive. , 1987, Archives of otolaryngology--head & neck surgery.

[15]  R. Fung,et al.  Review of cyanoacrylate tissue glues with emphasis on their otorhinolaryngological applications , 1984, The Laryngoscope.

[16]  A. Eden,et al.  Evaluation of Three Cyanoacrylate Glues for Ossicular Reconstruction , 1983, The Annals of otology, rhinology, and laryngology.

[17]  Siedentop Kh.  Tissue adhesive Histoacryl (2-cyano-butyl-acrylate) in experimental middle ear surgery. , 1980 .

[18]  K. H. Siedentop.  Tissue adhesive Histoacryl (2-cyano-butyl-acrylate) in experimental middle ear surgery. , 1980, The American journal of otology.

[19]  A. Kerr,et al.  Bucrylate (isobutyl cyanoacrylate) as an ossicular adhesive. , 1971, Archives of otolaryngology.