Saikosaponin A of Bupleurum chinense (Chaihu) elevates bone morphogenetic protein 4 (BMP-4) during hepatic stellate cell activation.

[1]  M. Liao,et al.  Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway. , 2012, International immunopharmacology.

[2]  K. Kuo,et al.  The Activation of MEK/ERK Signaling Pathway by Bone Morphogenetic Protein 4 to Increase Hepatocellular Carcinoma Cell Proliferation and Migration , 2012, Molecular Cancer Research.

[3]  B. Kim,et al.  Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines , 2011, Apoptosis.

[4]  Chun-Chao Chang,et al.  Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. , 2010, The American journal of Chinese medicine.

[5]  A. Bosserhoff,et al.  Bone morphogenetic protein 4 is induced in hepatocellular carcinoma by hypoxia and promotes tumour progression , 2009, The Journal of pathology.

[6]  Qiang Xu,et al.  Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and induction of apoptosis. , 2009, International immunopharmacology.

[7]  J. Chao,et al.  Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats. , 2008, Journal of medicinal food.

[8]  Ning Li,et al.  Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury. , 2007, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[9]  F. Burczynski,et al.  Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells , 2006, Journal of cellular physiology.

[10]  F. Marra,et al.  Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cells. , 2004, American journal of physiology. Gastrointestinal and liver physiology.

[11]  F. Thielemann,et al.  Bone morphogenetic protein: a review , 2004, International Orthopaedics.

[12]  R. Schwabe,et al.  NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. , 2003, The Journal of clinical investigation.

[13]  Manna Zhang,et al.  Transforming growth factor- 1 downregulation of Smad1 gene expression in rat hepatic stellate cells , 2003 .

[14]  Hong Shen,et al.  Effect of transforming growth factor beta and bone morphogenetic proteins on rat hepatic stellate cell proliferation and trans-differentiation. , 2003, World journal of gastroenterology.

[15]  Wu Wen-sheng,et al.  ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a , 2003, Oncogene.

[16]  HongShen,et al.  Effect of transforming growth factor beta and bone morphogenetic proteins on rat hepatic stellate cell proliferation and transdifferentiation , 2003 .

[17]  R. Kalluri,et al.  Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors. , 2003, Gastroenterology.

[18]  Jing-Gung Chung,et al.  Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells. , 2003, The American journal of Chinese medicine.

[19]  F. Marra,et al.  Chemokines in liver inflammation and fibrosis. , 2002, Frontiers in bioscience : a journal and virtual library.

[20]  M. Válková Hepatic fibrogenesis. , 2002, Bratislavske lekarske listy.

[21]  Manna Zhang,et al.  Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation , 2002, BMC Cell Biology.

[22]  Z. Kmieć,et al.  Cooperation of Liver Cells in Health and Disease , 2001, Advances in Anatomy Embryology and Cell Biology.

[23]  S. Duncan,et al.  BMPs on the road to hepatogenesis. , 2001, Genes & development.

[24]  M. Hsu,et al.  Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c‐myc, p53, and bcl‐2 mRNA , 2000, British journal of pharmacology.

[25]  S. Hokari,et al.  Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: Roles of transforming growth factor (TGF)‐β and bone morphogenetic protein (BMP) , 2000, The Anatomical record.

[26]  D. Brenner,et al.  New aspects of hepatic fibrosis. , 2000, Journal of hepatology.

[27]  K. Miyazono,et al.  Bone morphogenetic protein‐2 acts synergistically with transforming growth factor‐β3 during endothelial‐mesenchymal transformation in the developing chick heart , 1999, Journal of cellular physiology.

[28]  M. Pinzani,et al.  Biology of Hepatic Stellate Cells and Their Possible Relevance in the Pathogenesis of Portal Hypertension in Cirrhosis , 1999, Seminars in liver disease.

[29]  H. Senoo,et al.  Morphology of sites of adhesion between hepatic stellate cells (vitamin A‐storing cells) and a three‐dimensional extracellular matrix , 1998, The Anatomical record.

[30]  J. Wozney The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult. , 1998, European journal of oral sciences.

[31]  V. Rosen,et al.  Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. , 1998, Clinical orthopaedics and related research.

[32]  K. Miyazono,et al.  Bone morphogenetic protein receptors. , 1996, Bone.

[33]  G. Ramadori,et al.  Glial fibrillary acidic protein--a cell type specific marker for Ito cells in vivo and in vitro. , 1996, Journal of hepatology.

[34]  R. Gebhardt,et al.  Colocalization of three types of intermediate filament proteins in perisinusoidal stellate cells: glial fibrillary acidic protein as a new cellular marker. , 1996, European journal of cell biology.

[35]  B. Hogan,et al.  Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. , 1995, Genes & development.

[36]  K. Okita,et al.  Saikosaponin A‐induced cell death of a human hepatoma cell line (HUH‐7): The significance of the “sub‐G1 peak‘ in a DNA histogram , 1995, Pathology international.

[37]  M. Pinzani Novel insights into the biology and physiology of the Ito cell. , 1995, Pharmacology & therapeutics.

[38]  S. Friedman The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies , 1993 .

[39]  A. Gressner,et al.  The response of rat liver perisinusoidal lipocytes to polypeptide growth regulator changes with their transdifferentiation into myofibroblast-like cells in culture. , 1993, Journal of hepatology.

[40]  S. Friedman Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. , 1993, The New England journal of medicine.

[41]  S. Friedman,et al.  Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture , 1992, Hepatology.

[42]  T. Devereux,et al.  Functional and structural zonal hepatocyte heterogeneity--dynamics and ontogenic development. , 1988, Experimental pathology.

[43]  R. N. Macsween,et al.  Desmin‐containing stellate cells in rat liver; distribution in normal animals and response to experimental acute liver injury , 1986, The Journal of pathology.

[44]  D. Knook,et al.  Perisinusoidal fat-storing cells are the main vitamin A storage sites in rat liver. , 1985, Experimental cell research.

[45]  E R Weibel,et al.  Distribution of Organelles and Membranes between Hepatocytes and Nonhepatocytes in a Stereological Study , 2022 .