UV‐exposition and vitamin‐D: How much sunlight do we need?

UV‐exposition is considered as the main reason for the development of cancers of the skin. However, 90 to 100% of the Vitamin‐D reqirement is formed within the skin through the action of sunlight. Considering the results of epidemiological studies, that have detected an association of Vitamin‐D deficiency with various types of cancer (e.g. colon‐, prostate‐ and breast cancer), this is a real dilema. The cancer protective effect of vitamin‐D is contributed to the extra renal, local production of 1α,25(OH)2D3 by the 25‐hydroxyvitamin D‐1α‐hydroxylase, which has been detected in various tissues. In respect of the novel functions of vitamin‐D and the risk of adverse consequences in case of deficiency we have screened sun deprived risk groups (A: patients with genodermatoses connected with defects in sun‐induced DNA repair: n = 4: 3 patients with xeroderma pigmentosum and 1 patient with basal cell nevus syndrome; and B: non vitamin‐D substituted renal transplant recipients under immunosuppressants: n = 33) for their vitamin‐D status. As measure of the vitamin‐D store and as substrate for the 25‐hydroxyvitamin D‐1α‐hydroxylase basal 25(OH)D3 serum levels (Nichols Institute Diagnostika GmbH, Bad Nauheim, Germany) have been analysed. In both groups decreased basal 25(OH)D3 serum levels were detected. Therefore we demand a monitoring of vitamin‐D status in patients practising sun protection, in case of vitamin‐D deficiency an oral substitution should be recommended.

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