Discovery of cisplatin-binding proteins by competitive cysteinome profiling

A competitive activity-based protein profiling strategy was developed to identify cisplatin-binding cysteines in MCF-7 proteomes, among which cisplatin-binding sites in GLRX1, TXNDC17 and MetAP1 were biochemically verified.

[1]  E. Weerapana,et al.  Monitoring Fe–S cluster occupancy across the E. coli proteome using chemoproteomics , 2023, Nature Chemical Biology.

[2]  D. Nomura,et al.  Advances in covalent drug discovery , 2022, Nature Reviews Drug Discovery.

[3]  Eric P. Skaar,et al.  Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis , 2022, Cell.

[4]  Ji-Joon Song,et al.  Cisplatin fastens chromatin irreversibly even at a high chloride concentration , 2021, Nucleic acids research.

[5]  B. Cravatt,et al.  CIMAGE2.0: An Expanded Tool for Quantitative Analysis of Activity-Based Protein Profiling (ABPP) Data. , 2021, Journal of proteome research.

[6]  G. Natile,et al.  Interference between copper transport systems and platinum drugs. , 2021, Seminars in cancer biology.

[7]  K. Ahn,et al.  Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies , 2021, Molecules.

[8]  X. Qian,et al.  Proteomic analysis of cisplatin- and oxaliplatin-induced phosphorylation in proteins bound to Pt-DNA adducts. , 2020, Metallomics : integrated biometal science.

[9]  Sumit Ghosh.  Cisplatin: The first metal based anticancer drug. , 2019, Bioorganic chemistry.

[10]  Fan Yang,et al.  A Dimethyl-Labeling-Based Strategy for Site-Specifically Quantitative Chemical Proteomics. , 2018, Analytical chemistry.

[11]  V. DeRose,et al.  Platinum Binds Proteins in the Endoplasmic Reticulum of S. cerevisiae and Induces Endoplasmic Reticulum Stress. , 2017, ACS chemical biology.

[12]  W. Guo,et al.  Identification of binding sites of cisplatin to human copper chaperone protein Cox17 by high-resolution FT-ICR-MS. , 2016, Rapid communications in mass spectrometry : RCM.

[13]  A. Olson,et al.  Proteome-wide covalent ligand discovery in native biological systems , 2016, Nature.

[14]  B. Cravatt,et al.  Enzyme inhibitor discovery by activity-based protein profiling. , 2014, Annual review of biochemistry.

[15]  A. Merlino,et al.  Cisplatin binding to proteins: molecular structure of the ribonuclease a adduct. , 2014, Inorganic chemistry.

[16]  M. L. Mena,et al.  Combining TBP-based rOFFGEL-IEF with FASP and nLC-ESI-LTQ-MS/MS for the analysis of cisplatin-binding proteins in rat kidney. , 2014, Talanta.

[17]  E. Weerapana,et al.  A competitive chemical-proteomic platform to identify zinc-binding cysteines. , 2014, ACS chemical biology.

[18]  Benjamin F. Cravatt,et al.  A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles , 2013, Nature Methods.

[19]  A. Lázaro,et al.  LA-ICP-MS and nHPLC-ESI-LTQ-FT-MS/MS for the analysis of cisplatin–protein complexes separated by two dimensional gel electrophoresis in biological samples , 2012 .

[20]  A. Trapananti,et al.  Interaction of cisplatin with human superoxide dismutase. , 2012, Journal of the American Chemical Society.

[21]  P. Dyson,et al.  Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin. , 2011, Metallomics : integrated biometal science.

[22]  Daniela C Dieterich,et al.  Cleavable biotin probes for labeling of biomolecules via azide-alkyne cycloaddition. , 2010, Journal of the American Chemical Society.

[23]  Elias S. J. Arnér,et al.  Noble metal targeting of thioredoxin reductase--covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin. , 2010, Free radical biology & medicine.

[24]  David Baker,et al.  Quantitative reactivity profiling predicts functional cysteines in proteomes , 2010, Nature.

[25]  B. Michalke.  Platinum speciation used for elucidating activation or inhibition of Pt-containing anti-cancer drugs. , 2010, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[26]  A. Rosenzweig,et al.  Crystal structures of cisplatin bound to a human copper chaperone. , 2009, Journal of the American Chemical Society.

[27]  D. Wolters,et al.  Characterisation of cisplatin coordination sites in cellular Escherichia coli DNA-binding proteins by combined biphasic liquid chromatography and ESI tandem mass spectrometry , 2008, JBIC Journal of Biological Inorganic Chemistry.

[28]  L. Kèlland,et al.  The resurgence of platinum-based cancer chemotherapy , 2007, Nature Reviews Cancer.

[29]  Jun O. Liu,et al.  Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression , 2006, Proceedings of the National Academy of Sciences.

[30]  C. D. Thompson,et al.  Methionine aminopeptidases type I and type II are essential to control cell proliferation , 2005, Journal of cellular biochemistry.

[31]  S. Chaney,et al.  Protein interactions with platinum-DNA adducts: from structure to function. , 2004, Journal of inorganic biochemistry.

[32]  P. Dottino,et al.  Tumorigenesis and Neoplastic Progression Alterations in Nuclear Pore Architecture Allow Cancer Cell Entry into or Exit from Drug-Resistant Dormancy , 2011 .

[33]  Joseph A. Vetro,et al.  Yeast methionine aminopeptidase type 1 is ribosome‐associated and requires its N‐terminal zinc finger domain for normal function in vivo * , 2002, Journal of cellular biochemistry.