A 232-channel retinal vision prosthesis with a miniaturized hermetic package

Miniaturization of implantable devices while drastically increasing the number of stimulation channels is one of the greatest challenges in implant manufacturing because a small but hermetic package is needed that provides reliable protection for the electronics over decades. Retinal vision prostheses are the best example for it. This paper presents a miniaturized 232-channel vision prosthesis, summarizing the studies on the individual technologies that were developed, improved and combined to fabricate a telemetrically powered retinal device sample. The implantable unit, which is made out of a high temperature co-fired alumina ceramic package containing hermetic feedthroughs, electronic circuitry and a radio frequency coil for powering is manufactured through a modified screen-printing/lasering process. The package is sealed with solder glass to provide unaffected inductive coupling to the telemetric transmitter. A 0.05 cc inner volume allows helium leak testing and mathematical lifetime estimations for moisture-induced failure of up to 100 years. The feedthroughs contact a thin-film polyimide electrode array that utilizes DLC and SiC coatings for improved interlayer adhesion of the metallic tracks to the polymer carrier. Two metal layers allow integrated wiring of the electrode array within the very limited space.

[1]  P. Donaldson,et al.  Twenty years of neurological prosthesis-making. , 1987, Journal of biomedical engineering.

[2]  Thomas Guenther,et al.  Bionic vision: system architectures – a review , 2012, Expert review of medical devices.

[3]  Thomas Stieglitz,et al.  A device for vacuum drying, inert gas backfilling and solder sealing of hermetic implant packages , 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

[4]  David Daomin Zhou,et al.  Implantable Neural Prostheses 2 , 2010 .

[5]  Thomas Stieglitz,et al.  Long-term Adhesion Studies of Polyimide to Inorganic and Metallic Layers , 2012 .

[6]  Thomas Stieglitz,et al.  Hermetic glass soldered micro-packages for a vision prosthesis , 2012, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[7]  G. Dagnelie.  Comprar Visual Prosthetics. Physiology, Bioengineering And Rehabilitation + Dvd | G. Dagnelie | 9781441907530 | Springer , 2011 .

[8]  Christian Lang,et al.  An AC-powered optical receiver consuming 270μW for transcutaneous 2Mb/s data transfer , 2011, 2011 IEEE International Solid-State Circuits Conference.

[9]  Gislin Dagnelie,et al.  Visual prosthetics: physiology, bioengineering, rehabilitation. , 2011 .

[10]  M. Ortmanns,et al.  A 232-Channel Epiretinal Stimulator ASIC , 2007, IEEE Journal of Solid-State Circuits.

[11]  Maurits Ortmanns,et al.  A Neural Stimulator Frontend With High-Voltage Compliance and Programmable Pulse Shape for Epiretinal Implants , 2012, IEEE Journal of Solid-State Circuits.

[12]  Thomas Stieglitz,et al.  Ensuring minimal humidity levels in hermetic implant housings , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[13]  Thomas Stieglitz,et al.  Microflex: a new technique for hybrid integration for microsystems , 1998, Proceedings MEMS 98. IEEE. Eleventh Annual International Workshop on Micro Electro Mechanical Systems. An Investigation of Micro Structures, Sensors, Actuators, Machines and Systems (Cat. No.98CH36176.