Distribution and Form of Uranium-Containing Deposits in Chickens Treated with Uranyl Nitrate

The kidneys of chicks treated with uranyl nitrate were examined by electron microscopy. Most deposits of electron-dense material containing uranium were found in the lumina of distal tubules and collecting ducts of kidneys collected 12–24 hours post-treatment. Some deposits were present in extracellular spaces between adjacent cells. Only occasionally were deposits found intracellularly where they were associated with localized cellular degeneration. A generalized cellular degeneration over the whole kidney was seen 72–96 hours post-treatment, but this was not directly associated with the deposits of electron-dense material.

[1]  R. Harvey,et al.  Validation of impaired renal function chick model with uranyl nitrate , 1986, Bulletin of environmental contamination and toxicology.

[2]  D. Haley.  Morphologic changes in uranyl nitrate-induced acute renal failure in saline- and water-drinking rats. , 1982, Laboratory investigation; a journal of technical methods and pathology.

[3]  Siller Wg.  Renal pathology of the fowl--a review. , 1981 .

[4]  P. Jose,et al.  1395 THE INFLUENCE OF AGE ON URANYL NITRATE (UN) NEPHROTOXICITY , 1981, Pediatric Research.

[5]  W. Siller.  Renal pathology of the fowl--a review. , 1981, Avian pathology : journal of the W.V.P.A.

[6]  W. Siller,et al.  An investigation of urolithiasis in two flocks of laying fowls. , 1980, Avian pathology : journal of the W.V.P.A.

[7]  A. Evan,et al.  Glomerular endothelial cells in uranyl nitrate-induced acute renal failure in rats. , 1980, The Journal of clinical investigation.

[8]  R. Nagle,et al.  The initiation phase of experimental acute renal failure: an evaluation of uranyl nitrate-induced acute renal failure in the rat. , 1976, Kidney international. Supplement.

[9]  P. D. Sturkie.  Kidneys, Extrarenal Salt Excretion, and Urine , 1976 .

[10]  J. H. Stein,et al.  Pathophysiology of a nephrotoxic model of acute renal failure. , 1975, Kidney international.

[11]  R. Blantz.  The mechanism of acute renal failure after uranyl nitrate. , 1975, The Journal of clinical investigation.

[12]  E. Foulkes,et al.  SOME EFFECTS OF URANYL ACETATE ON PROXIMAL TUBULAR FUNCTION IN RABBIT KIDNEY. , 1968 .

[13]  H. Passow,et al.  The general pharmacology of the heavy metals. , 1961, Pharmacological reviews.

[14]  S. Madden,et al.  Acute tubular and glomerular lesions in rat kidneys after uranium injury. , 1960, Archives of pathology.

[15]  W. Neuman,et al.  The distribution and excretion of injected uranium. , 1948, The Journal of biological chemistry.

[16]  W. D. Macnider.  URINE FORMATION DURING THE ACUTE AND CHRONIC NEPHRITIS INDUCED BY URANIUM NITRATE. A CONSIDERATION OF THE FUNCTIONAL VALUE OF THE PROXIMAL CONVOLUTED TUBULE , 1929 .

[17]  E. C. Dickson.  A REPORT ON THE EXPERIMENTAL PRODUCTION OF CHRONIC NEPHRITIS IN ANIMALS BY THE USE OF URANIUM NITRATE. , 1909 .