The transmembrane adapter SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs
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M. Sweet | B. Kobe | J. Stow | K. Alexandrov | M. Mobli | Jason H. Whitfield | Neeraj Tuladhar | Lin Luo | J. Nanson | Yan Li | Liping Liu | James E. B. Curson | Richard M. Lucas
[1] M. Sweet,et al. An alternative downstream translation start site in the non‐TIR adaptor Scimp enables selective amplification of CpG DNA responses in mouse macrophages , 2022, Immunology and cell biology.
[2] Yvette W. H. Koh,et al. SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages. , 2021, Cell reports.
[3] Daniel S. Chertow,et al. Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic , 2020, The Journal of infectious diseases.
[4] K. Fitzgerald,et al. Toll-like Receptors and the Control of Immunity , 2020, Cell.
[5] M. Sweet,et al. SCIMP is a universal Toll‐like receptor adaptor in macrophages , 2020, Journal of leukocyte biology.
[6] J. Stow,et al. Signalling, sorting and scaffolding adaptors for Toll-like receptors , 2019, Journal of Cell Science.
[7] Timothy J. Hohman,et al. Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk , 2019, Nature Genetics.
[8] M. Marks,et al. Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling , 2018, PloS one.
[9] E. Im,et al. Src Family Kinase Tyrosine Phosphorylates Toll‐like Receptor 4 To Dissociate MyD88 And Mal/Tirap Suppressing LPS Induced Inflammatory Responses , 2018, Biochemical pharmacology.
[10] M. Sweet,et al. pTRAPs: Transmembrane adaptors in innate immune signaling , 2018, Journal of leukocyte biology.
[11] James R. Springstead,et al. By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome‐Dependent Phagocyte Hyperactivation , 2017, Immunity.
[12] F. Dimaio,et al. Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling , 2017, Nature Structural &Molecular Biology.
[13] Delong Liu,et al. Syk inhibitors in clinical development for hematological malignancies , 2017, Journal of Hematology & Oncology.
[14] M. Sweet,et al. Development of SH2 probes and pull‐down assays to detect pathogen‐induced, site‐specific tyrosine phosphorylation of the TLR adaptor SCIMP , 2017, Immunology and Cell Biology.
[15] M. Sweet,et al. SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages , 2017, Nature Communications.
[16] B. Malissen,et al. The Transmembrane Adaptor Protein SCIMP Facilitates Sustained Dectin-1 Signaling in Dendritic Cells* , 2016, The Journal of Biological Chemistry.
[17] G. Tsokos,et al. Targeting Syk in Autoimmune Rheumatic Diseases , 2016, Front. Immunol..
[18] G. Sen,et al. Tyrosine phosphorylation in Toll-like receptor signaling. , 2014, Cytokine & growth factor reviews.
[19] T. Jang,et al. Crystal structure of TIR domain of TLR6 reveals novel dimeric interface of TIR-TIR interaction for toll-like receptor signaling pathway. , 2014, Journal of molecular biology.
[20] A. Bowie,et al. The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 , 2014, Journal of leukocyte biology.
[21] Martyn F. Symmons,et al. Assembly and localization of Toll-like receptor signalling complexes , 2014, Nature Reviews Immunology.
[22] Jonathan D Wren,et al. Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes , 2014, Epigenetics.
[23] J. Stow,et al. Single‐step protease cleavage elution for identification of protein–protein interactions from GST pull‐down and mass spectrometry , 2014, Proteomics.
[24] C. Trautwein,et al. The innate immune response during liver inflammation and metabolic disease. , 2013, Trends in immunology.
[25] Duen-Yi Huang,et al. The Tyrosine Kinase Syk Differentially Regulates Toll-like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3 , 2013, Science Signaling.
[26] A. Drobek,et al. Nonredundant Roles of Src-Family Kinases and Syk in the Initiation of B-Cell Antigen Receptor Signaling , 2013, The Journal of Immunology.
[27] Soo-Ho Choi,et al. The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL , 2012, British journal of pharmacology.
[28] Masato Okada,et al. Regulation of the Src Family Kinases by Csk , 2012, International journal of biological sciences.
[29] E. Sundberg,et al. R753Q Polymorphism Inhibits Toll-like Receptor (TLR) 2 Tyrosine Phosphorylation, Dimerization with TLR6, and Recruitment of Myeloid Differentiation Primary Response Protein 88* , 2012, The Journal of Biological Chemistry.
[30] S. Akira,et al. Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response , 2012, Proceedings of the National Academy of Sciences.
[31] F. Granucci,et al. CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4 , 2011, Cell.
[32] M. Reth,et al. Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor , 2010, Proceedings of the National Academy of Sciences.
[33] M. Bachmann,et al. Averting inflammation by targeting the cytokine environment , 2010, Nature Reviews Drug Discovery.
[34] Nan Li,et al. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b , 2010, Nature Immunology.
[35] Victor L. J. Tybulewicz,et al. The SYK tyrosine kinase: a crucial player in diverse biological functions , 2010, Nature Reviews Immunology.
[36] Wan-Wan Lin,et al. Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway. , 2010, Molecular immunology.
[37] D. Underhill,et al. β‐glucan recognition by the innate immune system , 2009, Immunological reviews.
[38] M. Colonna,et al. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria , 2009, The Journal of cell biology.
[39] Gemma L. J. Fuller,et al. The C-type Lectin Receptors CLEC-2 and Dectin-1, but Not DC-SIGN, Signal via a Novel YXXL-dependent Signaling Cascade* , 2007, Journal of Biological Chemistry.
[40] A. Chaudhary,et al. Tyrosine kinase Syk associates with toll‐like receptor 4 and regulates signaling in human monocytic cells , 2007, Immunology and cell biology.
[41] S. Rhee,et al. Role of TLR4 Tyrosine Phosphorylation in Signal Transduction and Endotoxin Tolerance* , 2007, Journal of Biological Chemistry.
[42] L. Karlsson,et al. CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion , 2006, The Journal of cell biology.
[43] L. Lanier,et al. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12 , 2005, Nature Immunology.
[44] S. Gordon,et al. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. , 2005, Immunity.
[45] A. Mócsai,et al. Src and Syk kinases: key regulators of phagocytic cell activation. , 2005, Trends in immunology.
[46] Shizuo Akira,et al. Toll-like receptor signalling , 2004, Nature Reviews Immunology.
[47] A. Mócsai,et al. The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase , 2004 .
[48] S. Dower,et al. Toll-Like Receptors in Health and Disease: Complex Questions Remain1 , 2003, The Journal of Immunology.
[49] P. Ricciardi-Castagnoli,et al. A Critical Role for Syk Protein Tyrosine Kinase in Fc Receptor-Mediated Antigen Presentation and Induction of Dendritic Cell Maturation , 2003, The Journal of Immunology.
[50] Siamon Gordon,et al. Pattern Recognition Receptors Doubling Up for the Innate Immune Response , 2002, Cell.
[51] F. Collart,et al. A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site. , 2002, Protein expression and purification.
[52] M. Colonna,et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock , 2001, Nature.
[53] S. Amigorena,et al. syk protein tyrosine kinase regulates Fc receptor γ‐chain‐mediated transport to lysosomes , 1998 .
[54] Arthur Weiss,et al. ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain , 1992, Cell.
[55] M. Rossol,et al. LPS-induced cytokine production in human monocytes and macrophages. , 2011, Critical reviews in immunology.
[56] M. Hibbs,et al. Lyn tyrosine kinase: accentuating the positive and the negative. , 2005, Immunity.