The transmembrane adapter SCIMP recruits tyrosine kinase Syk to phosphorylate Toll-like receptors to mediate selective inflammatory outputs

[1]  M. Sweet,et al.  An alternative downstream translation start site in the non‐TIR adaptor Scimp enables selective amplification of CpG DNA responses in mouse macrophages , 2022, Immunology and cell biology.

[2]  Yvette W. H. Koh,et al.  SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages. , 2021, Cell reports.

[3]  Daniel S. Chertow,et al.  Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic , 2020, The Journal of infectious diseases.

[4]  K. Fitzgerald,et al.  Toll-like Receptors and the Control of Immunity , 2020, Cell.

[5]  M. Sweet,et al.  SCIMP is a universal Toll‐like receptor adaptor in macrophages , 2020, Journal of leukocyte biology.

[6]  J. Stow,et al.  Signalling, sorting and scaffolding adaptors for Toll-like receptors , 2019, Journal of Cell Science.

[7]  Timothy J. Hohman,et al.  Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk , 2019, Nature Genetics.

[8]  M. Marks,et al.  Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling , 2018, PloS one.

[9]  E. Im,et al.  Src Family Kinase Tyrosine Phosphorylates Toll‐like Receptor 4 To Dissociate MyD88 And Mal/Tirap Suppressing LPS Induced Inflammatory Responses , 2018, Biochemical pharmacology.

[10]  M. Sweet,et al.  pTRAPs: Transmembrane adaptors in innate immune signaling , 2018, Journal of leukocyte biology.

[11]  James R. Springstead,et al.  By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome‐Dependent Phagocyte Hyperactivation , 2017, Immunity.

[12]  F. Dimaio,et al.  Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling , 2017, Nature Structural &Molecular Biology.

[13]  Delong Liu,et al.  Syk inhibitors in clinical development for hematological malignancies , 2017, Journal of Hematology & Oncology.

[14]  M. Sweet,et al.  Development of SH2 probes and pull‐down assays to detect pathogen‐induced, site‐specific tyrosine phosphorylation of the TLR adaptor SCIMP , 2017, Immunology and Cell Biology.

[15]  M. Sweet,et al.  SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages , 2017, Nature Communications.

[16]  B. Malissen,et al.  The Transmembrane Adaptor Protein SCIMP Facilitates Sustained Dectin-1 Signaling in Dendritic Cells* , 2016, The Journal of Biological Chemistry.

[17]  G. Tsokos,et al.  Targeting Syk in Autoimmune Rheumatic Diseases , 2016, Front. Immunol..

[18]  G. Sen,et al.  Tyrosine phosphorylation in Toll-like receptor signaling. , 2014, Cytokine & growth factor reviews.

[19]  T. Jang,et al.  Crystal structure of TIR domain of TLR6 reveals novel dimeric interface of TIR-TIR interaction for toll-like receptor signaling pathway. , 2014, Journal of molecular biology.

[20]  A. Bowie,et al.  The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 , 2014, Journal of leukocyte biology.

[21]  Martyn F. Symmons,et al.  Assembly and localization of Toll-like receptor signalling complexes , 2014, Nature Reviews Immunology.

[22]  Jonathan D Wren,et al.  Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes , 2014, Epigenetics.

[23]  J. Stow,et al.  Single‐step protease cleavage elution for identification of protein–protein interactions from GST pull‐down and mass spectrometry , 2014, Proteomics.

[24]  C. Trautwein,et al.  The innate immune response during liver inflammation and metabolic disease. , 2013, Trends in immunology.

[25]  Duen-Yi Huang,et al.  The Tyrosine Kinase Syk Differentially Regulates Toll-like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3 , 2013, Science Signaling.

[26]  A. Drobek,et al.  Nonredundant Roles of Src-Family Kinases and Syk in the Initiation of B-Cell Antigen Receptor Signaling , 2013, The Journal of Immunology.

[27]  Soo-Ho Choi,et al.  The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL , 2012, British journal of pharmacology.

[28]  Masato Okada,et al.  Regulation of the Src Family Kinases by Csk , 2012, International journal of biological sciences.

[29]  E. Sundberg,et al.  R753Q Polymorphism Inhibits Toll-like Receptor (TLR) 2 Tyrosine Phosphorylation, Dimerization with TLR6, and Recruitment of Myeloid Differentiation Primary Response Protein 88* , 2012, The Journal of Biological Chemistry.

[30]  S. Akira,et al.  Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response , 2012, Proceedings of the National Academy of Sciences.

[31]  F. Granucci,et al.  CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4 , 2011, Cell.

[32]  M. Reth,et al.  Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor , 2010, Proceedings of the National Academy of Sciences.

[33]  M. Bachmann,et al.  Averting inflammation by targeting the cytokine environment , 2010, Nature Reviews Drug Discovery.

[34]  Nan Li,et al.  Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b , 2010, Nature Immunology.

[35]  Victor L. J. Tybulewicz,et al.  The SYK tyrosine kinase: a crucial player in diverse biological functions , 2010, Nature Reviews Immunology.

[36]  Wan-Wan Lin,et al.  Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway. , 2010, Molecular immunology.

[37]  D. Underhill,et al.  β‐glucan recognition by the innate immune system , 2009, Immunological reviews.

[38]  M. Colonna,et al.  TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria , 2009, The Journal of cell biology.

[39]  Gemma L. J. Fuller,et al.  The C-type Lectin Receptors CLEC-2 and Dectin-1, but Not DC-SIGN, Signal via a Novel YXXL-dependent Signaling Cascade* , 2007, Journal of Biological Chemistry.

[40]  A. Chaudhary,et al.  Tyrosine kinase Syk associates with toll‐like receptor 4 and regulates signaling in human monocytic cells , 2007, Immunology and cell biology.

[41]  S. Rhee,et al.  Role of TLR4 Tyrosine Phosphorylation in Signal Transduction and Endotoxin Tolerance* , 2007, Journal of Biological Chemistry.

[42]  L. Karlsson,et al.  CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion , 2006, The Journal of cell biology.

[43]  L. Lanier,et al.  Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12 , 2005, Nature Immunology.

[44]  S. Gordon,et al.  Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. , 2005, Immunity.

[45]  A. Mócsai,et al.  Src and Syk kinases: key regulators of phagocytic cell activation. , 2005, Trends in immunology.

[46]  Shizuo Akira,et al.  Toll-like receptor signalling , 2004, Nature Reviews Immunology.

[47]  A. Mócsai,et al.  The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase , 2004 .

[48]  S. Dower,et al.  Toll-Like Receptors in Health and Disease: Complex Questions Remain1 , 2003, The Journal of Immunology.

[49]  P. Ricciardi-Castagnoli,et al.  A Critical Role for Syk Protein Tyrosine Kinase in Fc Receptor-Mediated Antigen Presentation and Induction of Dendritic Cell Maturation , 2003, The Journal of Immunology.

[50]  Siamon Gordon,et al.  Pattern Recognition Receptors Doubling Up for the Innate Immune Response , 2002, Cell.

[51]  F. Collart,et al.  A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site. , 2002, Protein expression and purification.

[52]  M. Colonna,et al.  TREM-1 amplifies inflammation and is a crucial mediator of septic shock , 2001, Nature.

[53]  S. Amigorena,et al.  syk protein tyrosine kinase regulates Fc receptor γ‐chain‐mediated transport to lysosomes , 1998 .

[54]  Arthur Weiss,et al.  ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain , 1992, Cell.

[55]  M. Rossol,et al.  LPS-induced cytokine production in human monocytes and macrophages. , 2011, Critical reviews in immunology.

[56]  M. Hibbs,et al.  Lyn tyrosine kinase: accentuating the positive and the negative. , 2005, Immunity.