Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death

[1]  Bairong Shen,et al.  Alterations of NURR1 and Cytokines in the Peripheral Blood Mononuclear Cells: Combined Biomarkers for Parkinson’s Disease , 2018, Front. Aging Neurosci..

[2]  Li-gong Bian,et al.  Nurr1 promotes neurogenesis of dopaminergic neuron and represses inflammatory factors in the transwell coculture system of neural stem cells and microglia , 2018, CNS neuroscience & therapeutics.

[3]  Bin Wang,et al.  Wnt5a mediates the effects of Bushen Huoxue decoction on the migration of bone marrow mesenchymal stem cells in vitro , 2018, Chinese Medicine.

[4]  R. Heumann,et al.  Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells , 2018, Molecular Neurobiology.

[5]  B. Han,et al.  Genkwalathins A and B, new lathyrane-type diterpenes from Daphne genkwa , 2018, Natural product research.

[6]  Pranav U. Damale,et al.  The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism , 2018, The Journal of Pharmacology and Experimental Therapeutics.

[7]  J. Park,et al.  Age-dependent decrease of Nurr1 protein expression in the gerbil hippocampus , 2018, Biomedical reports.

[8]  Ashraf K. Bahgat,et al.  Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model , 2018, Molecular Neurobiology.

[9]  Hongping Chen,et al.  Neuroprotective effect of olfactory ensheathing cells co‐transfected with Nurr1 and Ngn2 in both in vitro and in vivo models of Parkinson's disease , 2018, Life sciences.

[10]  N. Minh,et al.  Daphnane and Phorbol Diterpenes, Anti-neuroinflammatory Compounds with Nurr1 Activation from the Roots and Stems of Daphne genkwa. , 2017, Biological & pharmaceutical bulletin.

[11]  Xuemei Xie,et al.  miR-145-5p/Nurr1/TNF-α Signaling-Induced Microglia Activation Regulates Neuron Injury of Acute Cerebral Ischemic/Reperfusion in Rats , 2017, Front. Mol. Neurosci..

[12]  Sandro Alves,et al.  Clinical Gene Therapy for Neurodegenerative Diseases: Past, Present, and Future. , 2017, Human gene therapy.

[13]  L. Ahmed,et al.  Modulatory Role of Nurr1 Activation and Thrombin Inhibition in the Neuroprotective Effects of Dabigatran Etexilate in Rotenone-Induced Parkinson’s Disease in Rats , 2017, Molecular Neurobiology.

[14]  D. Karabulut,et al.  Cellular Model of Alzheimer's Disease: Aβ1-42 Peptide Induces Amyloid Deposition and a Decrease in Topo Isomerase IIβ and Nurr1 Expression. , 2017, Current Alzheimer research.

[15]  D. Vassilatis,et al.  Nurr1:RXRα heterodimer activation as monotherapy for Parkinson’s disease , 2017, Proceedings of the National Academy of Sciences.

[16]  J. Shim,et al.  In vitro generation of mature midbrain-type dopamine neurons by adjusting exogenous Nurr1 and Foxa2 expressions to their physiologic patterns , 2017, Experimental &Molecular Medicine.

[17]  Hongyan Zhu,et al.  Orphan nuclear receptor Nurr1 as a potential novel marker for progression in human pancreatic ductal adenocarcinoma. , 2017, Experimental and therapeutic medicine.

[18]  Jayshree Nellore,et al.  Identification of NURR1 (Exon 4) and FOXA1 (Exon 3) Haplotypes Associated with mRNA Expression Levels in Peripheral Blood Lymphocytes of Parkinson's Patients in Small Indian Population , 2017, Parkinson's disease.

[19]  Wei Liu,et al.  Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 expression in both in vivo and in vitro Parkinson's disease models. , 2017, Biochemical and biophysical research communications.

[20]  Y. Pak,et al.  Protective effects of a herbal extract combination of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein , 2017, Neuroscience.

[21]  A. von Gunten,et al.  Efficacy of Ginkgo biloba extract EGb 761® in dementia with behavioural and psychological symptoms: A systematic review , 2016, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[22]  Eun Ji Song,et al.  The pharmacological stimulation of Nurr1 improves cognitive functions via enhancement of adult hippocampal neurogenesis. , 2016, Stem cell research.

[23]  Dan Chen,et al.  Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment , 2016, Molecular Neurobiology.

[24]  L. Rogers,et al.  Nurr1 expression is modified by inflammation in microglia , 2016, Neuroreport.

[25]  Kwang-Soo Kim,et al.  Daphnane Diterpenes from Daphne genkwa Activate Nurr1 and Have a Neuroprotective Effect in an Animal Model of Parkinson's Disease. , 2016, Journal of natural products.

[26]  Henry D. Wilson,et al.  Identification of a Binding Site for Unsaturated Fatty Acids in the Orphan Nuclear Receptor Nurr1. , 2016, ACS chemical biology.

[27]  Taosheng Chen,et al.  The orphan nuclear receptor NR4A2 is part of a p53–microRNA-34 network , 2016, Scientific Reports.

[28]  Hsin-Yi Huang,et al.  6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation , 2016, Journal of Neuroinflammation.

[29]  Chung-Hsin Wu,et al.  Treatment with a Ginkgo biloba extract, EGb 761, inhibits excitotoxicity in an animal model of spinocerebellar ataxia type 17 , 2016, Drug design, development and therapy.

[30]  R. Noelle,et al.  Treatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis. , 2016, American journal of translational research.

[31]  B. Blumberg,et al.  Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease , 2016, Oncotarget.

[32]  E. Joe,et al.  Combined Nurr1 and Foxa2 roles in the therapy of Parkinson's disease , 2016, EMBO molecular medicine.

[33]  B. Tang,et al.  Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment , 2015, Molecular Neurobiology.

[34]  S. Safe,et al.  A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro , 2015, Neuroscience Letters.

[35]  A. Bertolotto,et al.  Nurr1 reduction influences the onset of chronic EAE in mice , 2015, Inflammation Research.

[36]  Yolanda F. Darlington,et al.  Nuclear Receptor Signaling Atlas: Opening Access to the Biology of Nuclear Receptor Signaling Pathways , 2015, PloS one.

[37]  Yue Jiang,et al.  MicroRNA-132 promotes estradiol synthesis in ovarian granulosa cells via translational repression of Nurr1 , 2015, Reproductive Biology and Endocrinology.

[38]  N. Boulis,et al.  Gene therapy for neurodegenerative diseases. , 2015, Trends in molecular medicine.

[39]  Xichuang Chen,et al.  Efficacy and safety of extract of Ginkgo biloba as an adjunct therapy in chronic schizophrenia: A systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis , 2015, Psychiatry Research.

[40]  L. Yi,et al.  Dopamine Agonists Exert Nurr1-inducing Effect in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease , 2015, Chinese medical journal.

[41]  G. Petsko,et al.  Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease , 2015, Proceedings of the National Academy of Sciences.

[42]  S. Safe,et al.  Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma , 2015, PloS one.

[43]  B. D. De Miranda,et al.  The Nurr1 Activator 1,1-Bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB , 2015, Molecular Pharmacology.

[44]  Jiahuai Han,et al.  Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. , 2015, Nature chemical biology.

[45]  O. Isacson,et al.  A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C) , 2015, PloS one.

[46]  Lino Ferreira,et al.  Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease , 2015, Front. Aging Neurosci..

[47]  Z. Szondy,et al.  Retinoids induce Nur77-dependent apoptosis in mouse thymocytes. , 2015, Biochimica et biophysica acta.

[48]  J. Miller,et al.  Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease. , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[49]  J. Montaner,et al.  NURR1 Involvement in Recombinant Tissue-Type Plasminogen Activator Treatment Complications After Ischemic Stroke , 2015, Stroke.

[50]  Kwang-Soo Kim,et al.  Correlation between orphan nuclear receptor Nurr1 expression and amyloid deposition in 5XFAD mice, an animal model of Alzheimer's disease , 2015, Journal of neurochemistry.

[51]  Jing Cai,et al.  Bushen Huoxue decoction improves cognitive decline in rats with cerebral hypoperfusion. , 2014, Molecular medicine reports.

[52]  J. Reginster,et al.  Dabigatran Etexilate and Risk of Myocardial Infarction, Other Cardiovascular Events, Major Bleeding, and All‐Cause Mortality: A Systematic Review and Meta‐analysis of Randomized Controlled Trials , 2014, Journal of the American Heart Association.

[53]  P. Licznerski,et al.  The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed , 2014, Journal of Biomedical Science.

[54]  F. Blandini,et al.  Dopamine receptor agonists for Parkinson's disease , 2014, Expert opinion on investigational drugs.

[55]  D. Metzger,et al.  Nurr1 expression is regulated by voltage-dependent calcium channels and calcineurin in cultured hippocampal neurons , 2014, Neuroscience Letters.

[56]  A. Björklund,et al.  NURR1 in Parkinson disease—from pathogenesis to therapeutic potential , 2013, Nature Reviews Neurology.

[57]  G. Stoica,et al.  MicroRNA profiling and the role of microRNA-132 in neurodegeneration using a rat model , 2013, Neuroscience Letters.

[58]  Donna D. Zhang,et al.  The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death , 2013, Autophagy.

[59]  T. Abel,et al.  The NR4A orphan nuclear receptors mediate transcription-dependent hippocampal synaptic plasticity , 2013, Neurobiology of Learning and Memory.

[60]  S. Safe,et al.  Chemoprevention of Skin Cancer with 1,1-Bis (3′-Indolyl)-1-(Aromatic) Methane Analog through Induction of the Orphan Nuclear Receptor, NR4A2 (Nurr1) , 2013, PloS one.

[61]  A. Lang,et al.  Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients , 2013, Neurology.

[62]  D. Colagiovanni,et al.  Neuroprotective Efficacy and Pharmacokinetic Behavior of Novel Anti-Inflammatory Para-Phenyl Substituted Diindolylmethanes in a Mouse Model of Parkinson’s Disease , 2013, The Journal of Pharmacology and Experimental Therapeutics.

[63]  Jian Wang,et al.  Orphan nuclear receptor nurr1 as a potential novel marker for progression in human prostate cancer. , 2013, Asian Pacific journal of cancer prevention : APJCP.

[64]  B. Rowan,et al.  Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancer , 2013, BMC Cancer.

[65]  R. Sandberg,et al.  Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons , 2013, Proceedings of the National Academy of Sciences.

[66]  A. Björklund,et al.  α-Synuclein–Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons , 2012, Science Translational Medicine.

[67]  S. Ögren,et al.  Ginkgo biloba extract (EGb 761) modulates the expression of dopamine-related genes in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice , 2012, Neuroscience.

[68]  J. Jankovic,et al.  Anti-parkinsonian effects of Nurr1 activator in ubiquitin-proteasome system impairment induced animal model of Parkinson's disease. , 2012, CNS & neurological disorders drug targets.

[69]  H. You,et al.  Enhancement of the Tyrosinase Inhibitory Activity of Mori Cortex Radicis Extract by Biotransformation Using Leuconostoc paramesenteroides PR , 2012, Bioscience, biotechnology, and biochemistry.

[70]  J. Regan,et al.  Prostanoid EP1 receptors mediate up‐regulation of the orphan nuclear receptor Nurr1 by cAMP‐independent activation of protein kinase A, CREB and NF‐κB , 2012, British journal of pharmacology.

[71]  S. Safe,et al.  Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells. , 2012, Biochemical pharmacology.

[72]  J. A. Dani,et al.  Age-related changes in dopamine signaling in Nurr1 deficient mice as a model of Parkinson's disease , 2012, Neurobiology of Aging.

[73]  Dongho Lee,et al.  Moracenin D from Mori Cortex Radicis Protects SH‐SY5Y Cells against Dopamine‐induced Cell Death by Regulating Nurr1 and α‐Synuclein Expression , 2012, Phytotherapy research : PTR.

[74]  Yuanjia Tang,et al.  miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression , 2012, Journal of Cell Science.

[75]  Dehua Yang,et al.  Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons , 2012, Molecular Neurodegeneration.

[76]  B. Barneda-Zahonero,et al.  Nurr1 Protein Is Required for N-Methyl-d-aspartic Acid (NMDA) Receptor-mediated Neuronal Survival* , 2012, The Journal of Biological Chemistry.

[77]  Hai-ming Wang,et al.  [Effect of Bushen Huoxue Decoction on dopamine D2 receptor in the brain of rats with Parkinson's disease]. , 2011, Nan fang yi ke da xue xue bao = Journal of Southern Medical University.

[78]  Soo-Jin Jeong,et al.  Cortex Mori Radicis extract exerts antiasthmatic effects via enhancement of CD4(+)CD25(+)Foxp3(+) regulatory T cells and inhibition of Th2 cytokines in a mouse asthma model. , 2011, Journal of ethnopharmacology.

[79]  S. Safe,et al.  Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors. , 2011, Carcinogenesis.

[80]  Hai-ming Wang,et al.  Effect of Bushen Huoxue Decoction (补肾活血饮) on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson’s disease , 2011, Chinese Journal of Integrative Medicine.

[81]  Marcelo A. Wood,et al.  HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation , 2010, The Journal of Neuroscience.

[82]  C. Long-Smith,et al.  Interleukin-1β contributes to dopaminergic neuronal death induced by lipopolysaccharide-stimulated rat glia in vitro , 2010, Journal of Neuroimmunology.

[83]  T. Perlmann,et al.  Rapid increase of Nurr1 mRNA expression in limbic and cortical brain structures related to coping with depression‐like behavior in mice , 2010, Journal of neuroscience research.

[84]  S. Howng,et al.  6-Mercaptopurine exerts an immunomodulatory and neuroprotective effect on permanent focal cerebral occlusion in rats , 2010, Acta Neurochirurgica.

[85]  L. Kappos,et al.  Learning from Nature: Pregnancy Changes the Expression of Inflammation-Related Genes in Patients with Multiple Sclerosis , 2010, PloS one.

[86]  Y. Christen,et al.  The Extract of Ginkgo biloba EGb 761 Reactivates a Juvenile Profile in the Skeletal Muscle of Sarcopenic Rats by Transcriptional Reprogramming , 2009, PloS one.

[87]  M. Smidt,et al.  Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons , 2009, Development.

[88]  K. Shudo,et al.  Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF‐mediated signaling , 2009, Journal of neurochemistry.

[89]  F. Gage,et al.  A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death , 2009, Cell.

[90]  Xiaolan Fan,et al.  Nurr1 Expression and Its Modulation in Microglia , 2009, Neuroimmunomodulation.

[91]  M. Taketo,et al.  Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis , 2009, Nature Neuroscience.

[92]  Sung-Dae Cho,et al.  1,1-Bis(3′-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth , 2008, Molecular Cancer Therapeutics.

[93]  J. Jankovic,et al.  Decreased NURR1 gene expression in patients with Parkinson's disease , 2008, Journal of the Neurological Sciences.

[94]  B. Weimer,et al.  Cytosporone B is an agonist for nuclear orphan receptor Nur77. , 2008, Nature chemical biology.

[95]  Taosheng Chen,et al.  Nuclear receptor drug discovery. , 2008, Current opinion in chemical biology.

[96]  Tao Zhang,et al.  Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells , 2007, Neuroscience Letters.

[97]  T. Perlmann,et al.  Adult mice with reduced Nurr1 expression: an animal model for schizophrenia , 2007, Molecular Psychiatry.

[98]  D. Greco,et al.  Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro , 2007, Journal of neurochemistry.

[99]  Joel M Stein,et al.  Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation , 2007, The Journal of Neuroscience.

[100]  S. Hintermann,et al.  Identification of a series of highly potent activators of the Nurr1 signaling pathway. , 2007, Bioorganic & medicinal chemistry letters.

[101]  T. Kawase,et al.  Transplantation of post‐mitotic human neuroteratocarcinoma‐overexpressing Nurr1 cells provides therapeutic benefits in experimental stroke: In vitro evidence of expedited neuronal differentiation and GDNF secretion , 2007, Journal of neuroscience research.

[102]  Yu Luo,et al.  VIP is a transcriptional target of Nurr1 in dopaminergic cells , 2007, Experimental Neurology.

[103]  Mi Kyeong Lee,et al.  Regulation of GTP cyclohydrolase I expression by orphan receptor Nurr1 in cell culture and in vivo , 2006, Journal of neurochemistry.

[104]  C. Maldonado-Vlaar,et al.  Knockdown of Nurr1 in the rat hippocampus: implications to spatial discrimination learning and memory. , 2006, Learning & memory.

[105]  T. Perlmann,et al.  Characterization of the Nurr1 ligand-binding domain co-activator interaction surface. , 2006, Journal of molecular endocrinology.

[106]  C. Ferrari,et al.  Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1β in the substantia nigra , 2006, Neurobiology of Disease.

[107]  B. Botterman,et al.  Blocking Soluble Tumor Necrosis Factor Signaling with Dominant-Negative Tumor Necrosis Factor Inhibitor Attenuates Loss of Dopaminergic Neurons in Models of Parkinson's Disease , 2006, The Journal of Neuroscience.

[108]  J. Eells,et al.  Reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression, tyrosine hydroxylase activity, and associated neurochemical alterations in Nurr1-null heterozygous mice , 2006, Brain Research Bulletin.

[109]  G. Muscat,et al.  Review Nuclear Receptor Signaling | The Open Access Journal of the Nuclear Receptor Signaling Atlas The NR4A subgroup: immediate early response genes with pleiotropic physiological roles , 2022 .

[110]  J. Jankovic,et al.  Nurr1 in Parkinson's disease and related disorders , 2006, The Journal of comparative neurology.

[111]  A. Parker,et al.  Nurr1 dependent regulation of pro-inflammatory mediators in immortalised synovial fibroblasts , 2005, Journal of Inflammation.

[112]  J. Jankovic,et al.  Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[113]  J. Jankovic,et al.  The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease , 2005, Progress in Neurobiology.

[114]  K. Yoon,et al.  Activation of Nur77 by Selected 1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes Induces Apoptosis through Nuclear Pathways* , 2005, Journal of Biological Chemistry.

[115]  J. Satoh,et al.  Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis , 2005, Neurobiology of Disease.

[116]  Tianhong Pan,et al.  Biological effects of pramipexole on dopaminergic neuron-associated genes: relevance to neuroprotection , 2005, Neuroscience Letters.

[117]  J. Schwabe,et al.  Identification of a Novel Co-regulator Interaction Surface on the Ligand Binding Domain of Nurr1 Using NMR Footprinting* , 2004, Journal of Biological Chemistry.

[118]  Vincent Laudet,et al.  Principles for modulation of the nuclear receptor superfamily , 2004, Nature Reviews Drug Discovery.

[119]  V. Nikodem,et al.  Differential role of ERK in cAMP-induced Nurr1 expression in N2A and C6 cells , 2004, Neuroreport.

[120]  Elaine Fuchs,et al.  Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[121]  B. Joseph,et al.  Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells. , 2003, Experimental cell research.

[122]  K. S. A. Wansa,et al.  The AF-1 Domain of the Orphan Nuclear Receptor NOR-1 Mediates Trans-activation, Coactivator Recruitment, and Activation by the Purine Anti-metabolite 6-Mercaptopurine* , 2003, Journal of Biological Chemistry.

[123]  P. Ordentlich,et al.  Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1* , 2003, Journal of Biological Chemistry.

[124]  Xiaohong Liu,et al.  Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors , 2003, Nature.

[125]  J. Drouin,et al.  Dimer-Specific Potentiation of NGFI-B (Nur77) Transcriptional Activity by the Protein Kinase A Pathway and AF-1-Dependent Coactivator Recruitment , 2003, Molecular and Cellular Biology.

[126]  E. Cochran,et al.  Age‐related decreases in Nurr1 immunoreactivity in the human substantia nigra , 2002, The Journal of comparative neurology.

[127]  R. McKay,et al.  Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease , 2002, Nature.

[128]  G. Fiskum,et al.  Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia , 2001, Brain Research.

[129]  J. Granneman,et al.  Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism , 2001, Journal of neurochemistry.

[130]  G. Sedvall,et al.  NURR1 mutations in cases of schizophrenia and manic-depressive disorder. , 2000, American journal of medical genetics.

[131]  C. Maldonado-Vlaar,et al.  Hippocampal Expression of the Orphan Nuclear Receptor Gene hzf-3/nurr1 during Spatial Discrimination Learning , 2000, Neurobiology of Learning and Memory.

[132]  Y. Christen,et al.  The ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by β‐amyloid , 2000 .

[133]  B. Diamond,et al.  Ginkgo biloba extract: mechanisms and clinical indications. , 2000, Archives of physical medicine and rehabilitation.

[134]  Hideki Enomoto,et al.  The GDNF family ligands and receptors — implications for neural development , 2000, Current Opinion in Neurobiology.

[135]  M. Morales,et al.  A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain , 1999, Brain Research.

[136]  J. Drouin,et al.  Heterodimerization between Members of the Nur Subfamily of Orphan Nuclear Receptors as a Novel Mechanism for Gene Activation , 1999, Molecular and Cellular Biology.

[137]  J. Jankovic,et al.  Reduced Nurrl Expression Increases the Vulnerability of Mesencephalic Dopamine Neurons to MPTP‐Induced Injury , 1999, Journal of neurochemistry.

[138]  F. Gage,et al.  Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. , 1999, Development.

[139]  D. Richard,et al.  Dopamine and serotonin interactions in the modulation of the expression of the immediate-early transcription factor, nerve growth factor-inducible B, in the striatum , 1999, Neuroscience.

[140]  H. Ichinose,et al.  Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs. , 1999, Gene.

[141]  M. Smidt,et al.  Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[142]  B J Hoffer,et al.  Dopamine neuron agenesis in Nurr1-deficient mice. , 1997, Science.

[143]  L. Olson,et al.  Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system. , 1996, Brain research. Molecular brain research.

[144]  Y. Oyama,et al.  Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide , 1996, Brain Research.

[145]  T. Perlmann,et al.  A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. , 1995, Genes & development.

[146]  Xiaocui Wang,et al.  The lentiviral-mediated Nurr1 genetic engineering mesenchymal stem cells protect dopaminergic neurons in a rat model of Parkinson's disease. , 2018, American journal of translational research.

[147]  W. Le,et al.  Nurr1 deficiency-mediated inflammatory injury to nigral dopamine neurons in Parkinson’s disease , 2018 .

[148]  T. Abel,et al.  NR 4 A nuclear receptors support memory enhancement by histone deacetylase inhibitors , 2012 .

[149]  Xiaohong Sun,et al.  DJ-1 upregulates tyrosine hydroxylase gene expression by activating its transcriptional factor Nurr1 via the ERK1/2 pathway. , 2012, The international journal of biochemistry & cell biology.

[150]  Chia-Hsin Liao,et al.  A simple and efficient method for generating Nurr1-positive neuronal stem cells from human wisdom teeth (tNSC) and the potential of tNSC for stroke therapy. , 2009, Cytotherapy.

[151]  R. Paulsen,et al.  Three related brain nuclear receptors, NGFI-B, Nurr1, and NOR-1, as transcriptional activators , 2007, Journal of Molecular Neuroscience.

[152]  O. Conneely,et al.  Comparative distribution of NURR1 and NUR77 nuclear receptors in the mouse central nervous system , 2007, Journal of Molecular Neuroscience.

[153]  Hong Jiang,et al.  Mutations in NR4A2 associated with familial Parkinson disease , 2003, Nature Genetics.