Mutations in PLCZ1 induce male infertility associated with polyspermy and fertilization failure

[1]  Ling-bo Cai,et al.  Nucleoporin37 may play a role in early embryo development in human and mice. , 2022, Molecular human reproduction.

[2]  Ling-bo Cai,et al.  Novel bi-allelic variants in ACTL7A are associated with male infertility and total fertilization failure. , 2021, Human reproduction.

[3]  G. Lin,et al.  Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice. , 2021, American journal of human genetics.

[4]  F. Zhang,et al.  Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest , 2020, Science Advances.

[5]  Liying Yan,et al.  A novel homozygous mutation of phospholipase C zeta leading to defective human oocyte activation and fertilization failure. , 2020, Human reproduction.

[6]  J. Evans Preventing polyspermy in mammalian eggs—Contributions of the membrane block and other mechanisms , 2020, Molecular reproduction and development.

[7]  Ling Wu,et al.  Novel mutations in PLCZ1 cause male infertility due to fertilization failure or poor fertilization. , 2020, Human reproduction.

[8]  Ling Wu,et al.  The identification of novel mutations in PLCZ1 responsible for human fertilization failure and a therapeutic intervention by artificial oocyte activation. , 2020, Molecular human reproduction.

[9]  Anne E. Carlson,et al.  Ion channels and signaling pathways used in the fast polyspermy block , 2020, Molecular reproduction and development.

[10]  G. Lin,et al.  Novel homozygous variations in PLCZ1 lead to poor or failed fertilization characterized by abnormal localization patterns of PLCζ in sperm , 2019, Clinical genetics.

[11]  M. Avella,et al.  The molecular mechanisms mediating mammalian fertilization , 2019, Development.

[12]  R. Vassena,et al.  Novel phospholipase C zeta 1 mutations associated with fertilization failures after ICSI. , 2019, Human reproduction.

[13]  M. Ikawa,et al.  Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice , 2018, Scientific Reports.

[14]  Andrew R. Bassett,et al.  PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence , 2017, Development.

[15]  Eric W. Roth,et al.  Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy. , 2017, Integrative biology : quantitative biosciences from nano to macro.

[16]  J. Dean,et al.  A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice , 2017, PLoS genetics.

[17]  B. Heindryckx,et al.  Effect of two assisted oocyte activation protocols used to overcome fertilization failure on the activation potential and calcium releasing pattern. , 2016, Fertility and sterility.

[18]  M. Yeste,et al.  Oocyte activation deficiency: a role for an oocyte contribution? , 2016, Human reproduction update.

[19]  K. Iwata,et al.  Diagnosis of abnormal human fertilization status based on pronuclear origin and/or centrosome number , 2015, Journal of Assisted Reproduction and Genetics.

[20]  Michael J E Sternberg,et al.  The Phyre2 web portal for protein modeling, prediction and analysis , 2015, Nature Protocols.

[21]  J. Laven,et al.  Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications , 2014, Nature Communications.

[22]  Jin-ho Lim,et al.  Analysis of clinical outcomes with respect to spermatozoan origin after artificial oocyte activation with a calcium ionophore , 2013, Journal of Assisted Reproduction and Genetics.

[23]  D. Clift,et al.  Restarting life: fertilization and the transition from meiosis to mitosis , 2013, Nature Reviews Molecular Cell Biology.

[24]  Ling-bo Cai,et al.  Successful PGD for late infantile neuronal ceroid lipofuscinosis achieved by combined chromosome and TPP1 gene analysis. , 2013, Reproductive biomedicine online.

[25]  K. Coward,et al.  Oocyte activation and phospholipase C zeta (PLCζ): diagnostic and therapeutic implications for assisted reproductive technology , 2012, Cell Communication and Signaling.

[26]  Y. Iwao Egg activation in physiological polyspermy. , 2012, Reproduction.

[27]  B. Rosenbusch A preliminary concept, deduced from cytogenetic analyses, for explaining different types of multipronuclear oocytes obtained after intracytoplasmic sperm injection. , 2010, Fertility and sterility.

[28]  M. DePristo,et al.  The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. , 2010, Genome research.

[29]  H. Hakonarson,et al.  ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data , 2010, Nucleic acids research.

[30]  A. Salicioni,et al.  Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development. , 2008, The Journal of clinical investigation.

[31]  Allison J. Gardner,et al.  Mammalian membrane block to polyspermy: new insights into how mammalian eggs prevent fertilisation by multiple sperm. , 2006, Reproduction, Fertility and Development.

[32]  Z. Kouchi,et al.  The Role of EF-hand Domains and C2 Domain in Regulation of Enzymatic Activity of Phospholipase Cζ* , 2005, Journal of Biological Chemistry.

[33]  F. A. Lai,et al.  PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. , 2002, Development.

[34]  J. Egozcue,et al.  Diploid sperm and the origin of triploidy. , 2002, Human reproduction.

[35]  K. Sterzik,et al.  The chromosomal constitution of multipronuclear zygotes resulting from in-vitro fertilization. , 1997, Human reproduction.

[36]  K Schulten,et al.  VMD: visual molecular dynamics. , 1996, Journal of molecular graphics.

[37]  B. Bavister,et al.  A cell surface block to polyspermy occurs in golden hamster eggs. , 1988, Developmental biology.

[38]  K. Sato Polyspermy-preventing mechanisms in mouse eggs fertilized in vitro. , 1979, The Journal of experimental zoology.

[39]  L. Blayney,et al.  PLC ζ : a sperm-specific trigger of Ca 2 + oscillations in eggs and embryo development , 2022 .