Dictyostelium discoideum aggregation fields as excitable media.

Abstract This paper introduces some experimental investigations of wave propagation during aggregation of the cellular slime mould Dictyostelium discoideum (Dd) (Durston, unpublished results). It provides a basis for interpretation of the experimental findings by describing the excitable properties of aggregating Dd cells and some expectations about the nature of Dd wave propagation and the properties of the pacemaker regions which organize aggregation centers.

[1]  L. Wolpert.  Positional information and the spatial pattern of cellular differentiation. , 1969, Journal of theoretical biology.

[2]  J. Bonner.  Observations on polarity in the slime mold Dictyostelium discoideum. , 1950, The Biological bulletin.

[3]  John Tyler Bonner,et al.  AGGREGATION TERRITORIES IN THE CELLULAR SLIME MOLDS , 1962 .

[4]  B. Shaffer.  Aspects of Aggregation in Cellular Slime Moulds 1. Orientation and Chemotaxis , 1957, The American Naturalist.

[5]  D. Cotter,et al.  Properties of Germinating Spores of Dictyostelium discoideum , 1968, Journal of bacteriology.

[6]  J. Szurszewski,et al.  The effect of duodenal and mid small bowel transection on the frequency gradient of the pacesetter potential in the canine small intestine , 1970, The Journal of physiology.

[7]  C. Hutt,et al.  Predictions from Play , 1972, Nature.

[8]  G. Mitchison,et al.  Pattern formation in the blue-green alga, Anabaena. I. Basic mechanisms. , 1973, Journal of cell science.

[9]  W. Loomis.  Temperature-sensitive Mutants of Dictyostelium discoideum , 1969, Journal of bacteriology.

[10]  John Tyler Bonner,et al.  Cyclic Amp: A Naturally Occurring Acrasin in the Cellular Slime Molds , 1968, The American Naturalist.

[11]  John Tyler Bonner,et al.  A DESCRIPTIVE STUDY OF THE DEVELOPMENT OF THE SLIME MOLD DICTYOSTELIUM DISCOIDEUM , 1944 .

[12]  J. Bonner,et al.  Folic acid as second chemotactic substance in the cellular slime moulds. , 1972, Nature: New biology.

[13]  J. Bonner,et al.  Evidence for the formation of cell aggregates by chemotaxis in the development of the slime mold Dictyostelium discoideum. , 1947, The Journal of experimental zoology.

[14]  A. Winfree.  Spiral Waves of Chemical Activity , 1972, Science.

[15]  P. Farnsworth.  Morphogenesis in the cellular slime mould Dictyostelium discoideum; the formation and regulation of aggregate tips and the specification of developmental axes. , 1973, Journal of embryology and experimental morphology.

[16]  Güunther Gerisch,et al.  Chapter 6 Cell Aggregation and Differentiation in Dictyostelium , 1968 .

[17]  B. Goodwin,et al.  A phase-shift model for the spatial and temporal organization of developing systems. , 1969, Journal of theoretical biology.

[18]  T. M. Konijn,et al.  Cell aggregation in Dictyostelium discoideum. , 1961, Developmental biology.

[19]  K. Raper,et al.  Stalk formation in Dictyostelium. , 1950, Science.

[20]  M. Cohen,et al.  Wave propagation in the early stages of aggregation of cellular slime molds. , 1971, Journal of theoretical biology.

[21]  J. Bonner,et al.  Acrasin, Acrasinase, and the sensitivity to acrasin in Dictyostelium discoideum. , 1969, Developmental biology.

[22]  A. Zhabotinsky,et al.  Concentration Wave Propagation in Two-dimensional Liquid-phase Self-oscillating System , 1970, Nature.

[23]  A Robertson,et al.  Control of developing fields. , 1972, Annual review of biophysics and bioengineering.

[24]  M. Schwalb,et al.  Axenic Growth and Development of the Cellular Slime Mould, Dictyostelium discoideum , 1970 .

[25]  G. Webster.  Studies on pattern regulation in hydra. II. Factors controlling hypostome formation. , 1966, Journal of embryology and experimental morphology.

[26]  W. Loomis.  Acetylglucosaminidase, an Early Enzyme in the Development of Dictyostelium discoideum , 1969, Journal of Bacteriology.

[27]  M. Cohen,et al.  Chemotaxis and the early stages of aggregation in cellular slime molds. , 1971, Journal of theoretical biology.