The Growing Impact of Catalysis in the Pharmaceutical Industry
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Jinhua J. Song | Chris H. Senanayake | C. Senanayake | Daniel R Fandrick | Carl A. Busacca | Daniel R. Fandrick | C. Busacca
[1] G. C. Bailey,et al. Olefin Disproportionation. A New Catalytic Process , 1964 .
[2] B. Pugin,et al. Selective Hydrogenation for Fine Chemicals: Recent Trends and New Developments , 2003 .
[3] K. Sharpless,et al. Asymmetric epoxidation provides shortest routes to four chiral epoxy alcohols which are key intermediates in syntheses of methymycin, erythromycin, leukotriene C-1, and disparlure , 1981 .
[4] E. Jacobsen,et al. From the Cover: Organocatalysis Special Feature: Organocatalysis , 2010 .
[5] K. Mashima,et al. Highly stereoselective asymmetric hydrogenation of 2-benzamidomethyl-3-oxobutanoate catalysed by cationic binap–ruthenium(II) complexes , 1991 .
[6] T. Jamison,et al. Combinatorial libraries of transition-metal complexes, catalysts and materials. , 1998, Current opinion in chemical biology.
[7] Mary M. Jackson,et al. Asymmetric synthesis of an N-acylpyrrolidine for inhibition of HCV polymerase. , 2008, The Journal of organic chemistry.
[8] D. Milstein,et al. Direct synthesis of imines from alcohols and amines with liberation of H2. , 2010, Angewandte Chemie.
[9] K. Shimizu,et al. Discovery of Chiral Catalysts through Ligand Diversity: Ti‐Catalyzed Enantioselective Addition of TMSCN to meso Epoxides , 1996 .
[10] Paul H. Moran,et al. Industrial-scale synthesis and applications of asymmetric hydrogenation catalysts. , 2007, Accounts of chemical research.
[11] C. Senanayake,et al. Ambient temperature hydrophosphination of internal, unactivated alkynes and allenyl phosphineoxides with phosphine borane complexes. , 2009, Organic letters.
[12] S. Buchwald,et al. Catalysts for Suzuki-Miyaura coupling processes: scope and studies of the effect of ligand structure. , 2005, Journal of the American Chemical Society.
[13] R. Larock,et al. Synthesis of 2,3-Disubstituted Indoles via Palladium-Catalyzed Annulation of Internal Alkynes , 1998 .
[14] Paul N. Devine,et al. Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture , 2010, Science.
[15] Martin Poirier,et al. Peptide-based inhibitors of the hepatitis C virus NS3 protease: structure-activity relationship at the C-terminal position. , 2004, Journal of medicinal chemistry.
[16] K. Kent,et al. Practical synthesis of the anti-HIV drug, PMPA , 1998 .
[17] Roland Wohlgemuth,et al. Interfacing biocatalysis and organic synthesis , 2007, Journal of Chemical Technology & Biotechnology.
[18] K. Fandrick,et al. Catalytic Enantioselective Pyrrole Alkylations of α,β-Unsaturated 2-Acyl Imidazoles , 2006 .
[19] John H. Grate,et al. A green-by-design biocatalytic process for atorvastatin intermediate , 2010 .
[20] A. Hatzelmann,et al. Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds. , 1993, Biochemical pharmacology.
[21] R. Noyori. Asymmetrische Katalyse: Kenntnisstand und Perspektiven (Nobel-Vortrag) Copyright© The Nobel Foundation 2002. – Wir danken der Nobel-Stiftung, Stockholm, für die Genehmigung zum Druck einer deutschen Fassung des Vortrags. , 2002 .
[22] Eric N. Jacobsen,et al. (1S,2R)‐1‐Aminoindan‐2‐ol , 2003 .
[23] Scott R. Wilson,et al. Enantioselective Epoxidation of Unfunctionalized Olefins Catalyzed by (salen)Manganese Complexes , 1990 .
[24] Steven V. Ley,et al. New tools and concepts for modern organic synthesis , 2002, Nature Reviews Drug Discovery.
[25] Songbai Liu,et al. Catalytic enantioselective Cr-mediated propargylation: application to halichondrin synthesis. , 2009, Organic letters.
[26] Joseph V. Kurian,et al. A New Polymer Platform for the Future — Sorona® from Corn Derived 1,3-Propanediol , 2005 .
[27] G. Sauer,et al. New Type of Asymmetric Cyclization to Optically Active Steroid CD Partial Structures , 1971 .
[28] G. C. Fu,et al. Palladium-catalyzed coupling reactions of aryl chlorides. , 2002, Angewandte Chemie.
[29] S. Kobayakawa,et al. Selective cis Hydrogenation of o -Xylene and 1,2-Dimethylcyclohexene over Osmium and Iridium Catalysts , 1970 .
[30] Steven M. Mennen,et al. Asymmetric catalysis mediated by synthetic peptides. , 2007, Chemical reviews.
[31] R. Noyori,et al. Pioneering perspectives on asymmetric hydrogenation. , 2007, Accounts of chemical research.
[32] Klavs F. Jensen,et al. Overcoming the Challenges of Solid Bridging and Constriction during Pd-Catalyzed C−N Bond Formation in Microreactors , 2010 .
[33] J. Hartwig. Carbon–heteroatom bond formation catalysed by organometallic complexes , 2008, Nature.
[34] D. R. Parrish,et al. Asymmetric synthesis of bicyclic intermediates of natural product chemistry , 1974 .
[35] C. Senanayake,et al. Efficient monophosphorus ligands for palladium-catalyzed Miyaura borylation. , 2011, Organic letters.
[36] W. Knowles. Asymmetric hydrogenations (Nobel lecture). , 2002, Angewandte Chemie.
[37] Kuiling Ding,et al. Super‐High‐Throughput‐Screening chiraler Liganden und Aktivatoren: asymmetrische Aktivierung chiraler Diol‐Zink‐Katalysatoren durch chirale Stickstoffaktivatoren für die enantioselektive Addition von Diethylzink an Aldehyde , 1999 .
[38] J. Gillard,et al. Synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid vinyl-ACCA) derivatives: key intermediates for the preparation of inhibitors of the hepatitis C virus NS3 protease. , 2005, The Journal of organic chemistry.
[39] Sook-Kyung Yoon,et al. CATALYTIC ASYMMETRIC PROP-2-YNYLATION INVOLVING THE USE OF THE BIFUNCTIONAL SYNERGETIC REAGENT ET2BSPRI , 1997 .
[40] R. Grubbs,et al. Synthesis and activity of a new generation of ruthenium-based olefin metathesis catalysts coordinated with 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ligands. , 1999, Organic letters.
[41] Zadeo Cimarosti,et al. Application of Quality by Design Principles to Support Development of a Control Strategy for the Control of Genotoxic Impurities in the Manufacturing Process of a Drug Substance , 2010 .
[42] W. Trager,et al. High-yield synthesis of warfarin and its phenolic metabolites: new compounds. , 1983, Journal of pharmaceutical sciences.
[43] J. Hartwig,et al. C-H activation for the construction of C-B bonds. , 2010, Chemical reviews.
[44] M. Mccoy. CONTRACT MANUFACTURING Top firms invest in technology for biologics , 2010 .
[45] Steven V Ley,et al. A flow-based synthesis of imatinib: the API of Gleevec. , 2010, Chemical communications.
[46] Brian D. Doan,et al. Large-scale synthesis of SB-462795, a cathepsin K inhibitor: the RCM-based approaches , 2009 .
[47] A. Zanotti-gerosa,et al. Homogenous asymmetric hydrogenation: Recent trends and industrial applications. , 2011, Current opinion in drug discovery & development.
[48] Hisashi Yamamoto,et al. Chiral allenylboronic esters: a practical reagent for enantioselective carbon-carbon bond formation , 1982 .
[49] R. Vilar,et al. Monoligated palladium species as catalysts in cross-coupling reactions. , 2005, Angewandte Chemie.
[50] C. Senanayake,et al. The first regioselective palladium-catalyzed indolization of 2-bromo- or 2-chloroanilines with internal alkynes: a new approach to 2,3-disubstituted indoles. , 2004, Organic letters.
[51] Ming Zhang. Construction of Heterocycle Scaffolds via Transition Metal‐ Catalyzed sp2 C ? H Functionalization , 2009 .
[52] Xumu Zhang,et al. Highly enantioselective Ag(i)-catalyzed [3 + 2] cycloaddition of azomethine ylides. , 2002, Journal of the American Chemical Society.
[53] J. Bäckvall,et al. Combination of enzymes and metal catalysts. A powerful approach in asymmetric catalysis. , 2003, Chemical reviews.
[54] David B. Damon,et al. Asymmetric Synthesis of the Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib , 2006 .
[55] H. Kagan. Asymmetric catalysis by chiral rhodium complexes in hydrogenation and hydrosilylation reactions , 1975 .
[56] Sambasivarao Kotha,et al. Recent applications of the Suzuki–Miyaura cross-coupling reaction in organic synthesis , 2002 .
[57] P. Bonneau,et al. Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection. , 2003, Angewandte Chemie.
[58] E. Jacobsen,et al. Highly Enantioselective, Low-Temperature Epoxidation of Styrene , 1994 .
[59] Yian Shi,et al. An Efficient Catalytic Asymmetric Epoxidation Method , 1997 .
[60] P. Kocieňski,et al. Synthesis of (+)-manoalide via a copper(I)-mediated 1,2-metalate rearrangement. , 2003, The Journal of organic chemistry.
[61] K. Gothelf,et al. Catalytic asymmetric 1,3-dipolar cycloaddition reactions of azomethine ylides-a simple approach to optically active highly functionalized proline derivatives. , 2002, Angewandte Chemie.
[62] Shuj Kobayashi,et al. Catalytic asymmetric Mukaiyama aldol reactions in aqueous media , 1999 .
[63] N. Hu,et al. Ligand-Accelerated Catalysis of the Ullmann Condensation: Application to Hole Conducting Triarylamines , 1999 .
[64] C. Senanayake,et al. Mechanistic Study of the Jacobsen Asymmetric Epoxidation of Indene. , 1997, The Journal of organic chemistry.
[65] W. Knowles. Asymmetrische Hydrierungen (Nobel-Vortrag) Copyright© The Nobel Foundation 2002. – Wir danken der Nobel-Stiftung, Stockholm, für die Genehmigung zum Druck einer deutschen Fassung des Vortrags. , 2002 .
[66] M. Lemaire,et al. Aryl-aryl bond formation one century after the discovery of the Ullmann reaction. , 2002, Chemical reviews.
[67] S. Buchwald,et al. An efficient copper-catalyzed coupling of aryl halides with imidazoles , 1999 .
[68] T. Hashimoto,et al. Catalytic asymmetric allylation of aldehydes and related reactions with bis(((S)-binaphthoxy)(isopropoxy)titanium) oxide as a mu-oxo-type chiral Lewis acid. , 2003, Chemistry.
[69] and Peter J. Harrington,et al. Twenty Years of Naproxen Technology , 1997 .
[70] Paul S. Sabila,et al. A superior method for the reduction of secondary phosphine oxides. , 2005, Organic letters.
[71] M. Sigman,et al. A General Catalyst for the Asymmetric Strecker Reaction This work was supported by the NIH (GM-43214). A postdoctoral fellowship to M.S.S. (NIH), and a predoctoral fellowship to P.V. sponsored by Alfred Bader are gratefully acknowledged. , 2000, Angewandte Chemie.
[72] M. A. Stahmann,et al. Studies on 4-Hydroxycoumarins. V. The Condensation of α,β-Unsaturated Ketones with 4-Hydroxycoumarin1 , 1944 .
[73] Kari Rissanen,et al. Calix[4]arene-functionalized naphthalene and perylene imide dyes. , 2002, Organic letters.
[74] Martin Poirier,et al. Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans. , 2004, Organic letters.
[75] Mark E. Scott,et al. Aryl-aryl bond formation by transition-metal-catalyzed direct arylation. , 2007, Chemical reviews.
[76] I. Gallou,et al. cis-1-Amino-2-indanol in drug design and applications to asymmetric processes. , 2006, Chemical reviews.
[77] M. Shair,et al. Reaction microarrays: a method for rapidly determining the enantiomeric excess of thousands of samples. , 2001, Journal of the American Chemical Society.
[78] Akira Suzuki,et al. Recent advances in the cross-coupling reactions of organoboron derivatives with organic electrophiles, 1995–1998 , 1999 .
[79] J. P. Harrity,et al. A Recyclable Ru-Based Metathesis Catalyst , 1999 .
[80] W. Herrmann,et al. EINE NEUE GENERATION VON RUTHENIUMKATALYSATOREN FUR DIE OLEFINMETATHESE , 1998 .
[81] Roger A. Sheldon,et al. The E Factor: fifteen years on , 2007 .
[82] Andreas Pfaltz,et al. Iridium‐katalysierte asymmetrische Hydrierung nichtfunktionalisierter tetrasubstituierter Alkene , 2007 .
[83] D. Baker. Esomeprazole magnesium (Nexium). , 2001, Reviews in gastroenterological disorders.
[84] J. Hartwig,et al. Silyl-directed, iridium-catalyzed ortho-borylation of arenes. A one-pot ortho-borylation of phenols, arylamines, and alkylarenes. , 2008, Journal of the American Chemical Society.
[85] S. Ley,et al. Total synthesis of the anti-apoptotic agents iso- and bongkrekic acids. , 2010, Organic letters.
[86] Bradley M. Wile,et al. Enantiopure Pyridine Bis(oxazoline) “Pybox” and Bis(oxazoline) “Box” Iron Dialkyl Complexes: Comparison to Bis(imino)pyridine Compounds and Application to Catalytic Hydrosilylation of Ketones , 2009 .
[87] Yian Shi,et al. Synthesis of 1,2:4,5‐Di‐O‐Isopropylidene‐D‐Erythro‐2,3‐Hexodiulo‐2,6‐Pyranose. A Highly Enantioselective Ketone Catalyst for Epoxidation , 2003 .
[88] H. Wittcoff,et al. Real World of Industrial Chemistry: The SHOP Process: An Example of Industrial Creativity. , 1988 .
[89] C. Senanayake,et al. A general and special catalyst for Suzuki-Miyaura coupling processes. , 2010, Angewandte Chemie.
[90] Wei Chen,et al. Highly enantioselective michael addition of cyclic 1,3-dicarbonyl compounds to alpha,beta-unsaturated ketones. , 2007, Organic letters.
[91] Melanie S Sanford,et al. Palladium-catalyzed ligand-directed C-H functionalization reactions. , 2010, Chemical reviews.
[92] C. Senanayake,et al. Large-scale asymmetric synthesis of a cathepsin S inhibitor. , 2010, The Journal of organic chemistry.
[93] C. Senanayake,et al. Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation. , 2010, Organic letters.
[94] M. Tokunaga,et al. Asymmetric catalysis with water: efficient kinetic resolution of terminal epoxides by means of catalytic hydrolysis. , 1997, Science.
[95] N. Miyaura,et al. A stoichiometric aromatic CbondH borylation catalyzed by iridium(i)/2,2'-bipyridine complexes at room temperature. , 2002, Angewandte Chemie.
[96] Michael A Evans,et al. Isotopically chiral probes for in situ high-throughput asymmetric reaction analysis. , 2002, Journal of the American Chemical Society.
[97] D. Milstein,et al. Selective synthesis of primary amines directly from alcohols and ammonia. , 2008, Angewandte Chemie.
[98] Haibing Guo,et al. New syntheses of E7389 C14-C35 and halichondrin C14-C38 building blocks: double-inversion approach. , 2009, Journal of the American Chemical Society.
[99] Yong Tang,et al. Asymmetric Nazarov reaction catalyzed by chiral tris(oxazoline)/copper(II). , 2010, Angewandte Chemie.
[100] Takao Saito,et al. Developments in asymmetric hydrogenation from an industrial perspective. , 2007, Accounts of chemical research.
[101] J. Hartwig,et al. Palladium-catalyzed synthesis of arylamines from aryl halides. Mechanistic studies lead to coupling in the absence of tin reagents , 1995 .
[102] S. King,et al. Development of a catalytic enantioselective conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes for the synthesis of endothelin-A antagonist ABT-546. Scope, mechanism, and further application to the synthesis of the antidepressant rolipram. , 2002, Journal of the American Chemical Society.
[103] C. Müller,et al. Direkte Aminierung von sekundären Alkoholen mit Ammoniak , 2010 .
[104] Milton R. Smith,et al. Stoichiometric and Catalytic B−C Bond Formation from Unactivated Hydrocarbons and Boranes , 1999 .
[105] H. Kagan,et al. Asymmetric catalytic reduction with transition metal complexes. I. Catalytic system of rhodium(I) with (-)-2,3-0-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane, a new chiral diphosphine , 1972 .
[106] Xudong Wei,et al. Efficient large-scale synthesis of BILN 2061, a potent HCV protease inhibitor, by a convergent approach based on ring-closing metathesis. , 2006, The Journal of organic chemistry.
[107] C. Senanayake,et al. Novel and efficient chiral bisphosphorus ligands for rhodium-catalyzed asymmetric hydrogenation. , 2010, Organic letters.
[108] Xiang Liu,et al. Dramatic improvement in catalyst loadings and molar ratios of coupling partners for Ni/Cr-mediated coupling reactions: heterobimetallic catalysts. , 2009, Journal of the American Chemical Society.
[109] W. Tian,et al. Optimization and Scale-up of a Pd-Catalyzed Aromatic C−N Bond Formation: A Key Step in the Synthesis of a Novel 5-HT1B Receptor Antagonist , 2008 .
[110] H. Neumann,et al. An efficient and general synthesis of primary amines by ruthenium-catalyzed amination of secondary alcohols with ammonia. , 2010, Angewandte Chemie.
[111] S. Buchwald,et al. Dialkylbiaryl Phosphines in Pd-Catalyzed Amination: A User's Guide. , 2010, Chemical science.
[112] S. Buchwald,et al. A Simple Catalytic Method for the Conversion of Aryl Bromides to Arylamines , 1995 .
[113] D. Vogt,et al. Direct amination of secondary alcohols using ammonia. , 2010, Angewandte Chemie.
[114] K. Sharpless,et al. The first practical method for asymmetric epoxidation , 1980 .
[115] D. MacMillan,et al. New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels−Alder Reaction , 2000 .
[116] T. Netscher,et al. Asymmetric Hydrogenation of Unfunctionalized, Purely Alkyl-Substituted Olefins , 2006, Science.
[117] S. Sakuraba,et al. Practical Asymmetric Synthesis of (R)-Fluoxetine Hydrochloride Catalyzed by (2S, 4S)-4-Dicyclohexylphosphino-2-diphenylphosphinomethyl-1-(N-methylcarbamoyl)pyrrolidine-Rhodium Complex1 , 1991 .
[118] Lawrence X. Yu. Pharmaceutical Quality by Design: Product and Process Development, Understanding, and Control , 2008, Pharmaceutical Research.
[119] W. Cullen,et al. Asymmetric homogeneous hydrogenation of imines using rhodium-phosphine systems , 1990 .
[120] S. Jasmin,et al. Commercialization of the hydrolytic kinetic resolution of racemic epoxides: toward the economical large-scale production of enantiopure epichlorohydrin , 2003 .
[121] J. Tedrow,et al. Highly enantioselective syntheses of homopropargylic alcohols and dihydrofurans catalyzed by a bis(oxazolinyl)pyridine-scandium triflate complex. , 2001, Journal of the American Chemical Society.
[122] E. Grabowski,et al. Efficient catalytic asymmetric alkylations. 3. A kinetic and mechanistic study of the enantioselective phase-transfer methylation of 6,7-dichloro-5-methoxy-2-phenyl-1-indanone , 1987 .
[123] R. Grubbs,et al. Increased ring closing metathesis activity of ruthenium-based olefin metathesis catalysts coordinated with imidazolin-2-ylidene ligands , 1999 .
[124] Steven R. LaPlante,et al. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus , 2003, Nature.
[125] M. Sibi,et al. The role of the achiral template in enantioselective transformations. Radical conjugate additions to alpha-methacrylates followed by hydrogen atom transfer. , 2002, Journal of the American Chemical Society.
[126] J. Kochi,et al. Epoxidation of olefins with cationic (salen)manganese(III) complexes. The modulation of catalytic activity by substituents. , 1986, Journal of the American Chemical Society.
[127] Wei Zhang,et al. Highly enantioselective epoxidation catalysts derived from 1,2-diaminocyclohexane , 1991 .
[128] Ken D. Shimizu,et al. ENTWICKLUNG VON CHIRALEN KATALYSATOREN DURCH KOMBINATORISCHE LIGANDENVARIATION : TI-KATALYSIERTE ENANTIOSELEKTIVE ADDITION VON TMSCN AN MESO-EPOXIDE , 1996 .
[129] B. Trost,et al. The atom economy--a search for synthetic efficiency. , 1991, Science.
[130] J. Marino,et al. Stereocontrolled synthesis of (-)-macrolactin A. , 2002, Journal of the American Chemical Society.
[131] M. Lautens,et al. Construction of nitrogen-containing heterocycles by C-H bond functionalization. , 2009, Chemistry.
[132] Michael P. Ryan,et al. Risk Assessment of Potentially Genotoxic Impurities within the Framework of Quality by Design , 2010 .
[133] M. Nakada,et al. Studies on catalytic asymmetric Nozaki-Hiyama propargylation. , 2004, Organic letters.
[134] Eric N. Jacobsen,et al. SCHIFF BASE CATALYSTS FOR THE ASYMMETRIC STRECKER REACTION IDENTIFIED AND OPTIMIZED FROM PARALLEL SYNTHETIC LIBRARIES , 1998 .
[135] Jinhua J. Song,et al. Achieving synthetic efficiency through new method development , 2008 .
[136] H. Kumobayashi. Industrial application of asymmetric reactions catalyzed by BINAP-metal complexes , 1996 .
[137] J. M. Patel. Biocatalytic synthesis of atorvastatin intermediates , 2009 .
[138] B. Trost,et al. Ligand-accelerated enantioselective propargylation of aldehydes via allenylzinc reagents. , 2011, Organic letters.
[139] E. Jacobsen,et al. Highly active oligomeric (salen)co catalysts for asymmetric epoxide ring-opening reactions. , 2001, Journal of the American Chemical Society.
[140] M. Dobrinska,et al. Stereoselectivity in the disposition and metabolism of the uricosuric-diuretic agent, indacrinone, in Rhesus monkeys. , 1982, Drug metabolism and disposition: the biological fate of chemicals.
[141] E. Corey,et al. A practical and general enantioselective synthesis of chiral propa-1,2-dienyl and propargyl carbinols , 1990 .
[142] D. Ager,et al. An epoxidation approach to a chiral lactone : Application of the shi epoxidation , 2007 .
[143] Martin Poirier,et al. Structure-activity study on a novel series of macrocyclic inhibitors of the hepatitis C virus NS3 protease leading to the discovery of BILN 2061. , 2004, Journal of medicinal chemistry.
[144] Ryoji Noyori,et al. Asymmetric catalysis: science and opportunities (Nobel lecture). , 2002, Angewandte Chemie.
[145] Barry M. Trost,et al. Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way , 1995 .
[146] J. A. Marshall. Chiral allylic and allenic metal reagents for organic synthesis. , 2007, The Journal of organic chemistry.
[147] Sukbok Chang,et al. Effect of Chiral Quaternary Ammonium Salts on (salen)Mn-Catalyzed Epoxidation of cis-Olefins. A Highly Enantioselective, Catalytic Route to Trans-Epoxides , 1994 .
[148] S. G. Nelson,et al. Catalytic asymmetric Claisen rearrangement of unactivated allyl vinyl ethers. , 2010, Journal of the American Chemical Society.
[149] H. Blaser. The Chiral Switch of (S)‐Metolachlor: A Personal Account of an Industrial Odyssey in Asymmetric Catalysis , 2002 .
[150] Volodymyr Sashuk,et al. Nitro-substituted Hoveyda-Grubbs ruthenium carbenes: enhancement of catalyst activity through electronic activation. , 2004, Journal of the American Chemical Society.
[151] A. Pfaltz,et al. Iridium-catalyzed asymmetric hydrogenation of unfunctionalized, trialkyl-substituted olefins. , 2007, Chemistry, an Asian journal.
[152] Xiaoming Chen,et al. Asymmetric synthesis of homopropargylic alcohols from aldehydes and allenyltri-n-butylstannane , 1994 .
[153] R. Larsen,et al. A practical asymmetric synthesis of LTD4 antagonist , 1994 .
[154] M. Palucki,et al. Molybdenum-Catalyzed Asymmetric Allylic Alkylation Reactions Using Mo(CO)6 as Precatalyst , 2001 .
[155] Thomas Nicola,et al. First Scale-Up to Production Scale of a Ring Closing Metathesis Reaction Forming a 15-Membered Macrocycle as a Precursor of an Active Pharmaceutical Ingredient , 2005 .
[156] Jinhua J. Song,et al. Zinc catalyzed and mediated propargylations with propargyl boronates. , 2010, Organic letters.
[157] R. Noyori. Asymmetric Catalysis: Science and Opportunities (Nobel Lecture 2001). , 2003 .
[158] T. Mukaiyama,et al. Asymmetric Allylation with a New Chiral Allylating Agent Prepared from Tin(II) Triflate, Chiral Diamine, and Allylaluminum , 1987 .
[159] Hanna Cotton,et al. Asymmetric synthesis of esomeprazole , 2000 .
[160] Javier Magano,et al. Large-scale applications of transition metal-catalyzed couplings for the synthesis of pharmaceuticals. , 2011, Chemical reviews.
[161] F. Furia,et al. Synthesis of chiral sulfoxides by metal-catalyzed oxidation with t-butyl hydroperoxide , 1984 .
[162] Qi‐Lin Zhou,et al. Chiral diphosphine and monodentate phosphorus ligands on a spiro scaffold for transition-metal-catalyzed asymmetric reactions. , 2008, Accounts of chemical research.
[163] K. Achiwa. Asymmetric hydrogenation with new chiral functionalized bisphosphine-rhodium complexes , 1976 .
[164] C. Senanayake,et al. A new and practical boronic acid catalyzed intramolecular cyclodehydration of ureas for the synthesis of LFA-1 antagonists , 2011 .
[165] M. Palucki,et al. Solvent-dependent dynamic kinetic asymmetric transformation/kinetic resolution in molybdenum-catalyzed asymmetric allylic alkylations. , 2002, The Journal of organic chemistry.
[166] P. Reddy,et al. Preparation of optically pure esomeprazole and its related salt , 2006 .
[167] C. Senanayake,et al. A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions. , 2006, Organic letters.
[168] Xudong Wei,et al. RCM macrocyclization made practical: an efficient synthesis of HCV protease inhibitor BILN 2061. , 2008, Organic letters.
[169] E. Jacobsen,et al. Highly Enantioselective, Catalytic Epoxidation of Trisubstituted Olefins , 1994 .
[170] B. Singaram,et al. Asymmetric indium-mediated synthesis of homopropargylic alcohols , 2006 .
[171] Construction of indole nucleus through C-H functionalization reactions , 2010 .
[172] Scott J. Miller,et al. A case of remote asymmetric induction in the peptide-catalyzed desymmetrization of a bis(phenol). , 2008, Journal of the American Chemical Society.
[173] Hyunwoo Kim,et al. Substrate-directed stereoselectivity in vicinal diamine-catalyzed synthesis of warfarin. , 2006, Organic letters.
[174] Ramon Vilar,et al. Einfach koordinierte Palladiumspezies als Katalysatoren in Kreuzkupplungen , 2005 .
[175] Peter W. White,et al. Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease , 2010, Antimicrobial Agents and Chemotherapy.
[176] D. Urabe,et al. New syntheses of E7389 C14-C35 and halichondrin C14-C38 building blocks: reductive cyclization and oxy-Michael cyclization approaches. , 2009, Journal of the American Chemical Society.
[177] W. Cullen,et al. Rhodium(I)-catalysed asymmetric hydrogenation of imines , 1988 .
[178] Hisashi Yamamoto,et al. TBOxCr(III)Cl-catalyzed enantioselective synthesis of 1,3-butadien-2-ylcarbinols. , 2008, Organic letters.
[179] C. Senanayake,et al. Reduction of Phosphinites,Phosphinates, and Related Species with DIBAL-H , 2009 .
[180] O. Lavastre,et al. 500 μm diameter beads as single reactors to screen organometallic catalysts: discovery of a new supported catalyst for the hydrosilylation of ketones , 2002 .
[181] C. Senanayake,et al. The role of 4-(3-phenylpropyl)pyridine N-Oxide (P3NO) in the manganese-salen-catalyzed asymmetric epoxidation of indene , 1996 .
[182] M. Bandini,et al. The first catalytic enantioselective Nozaki–Hiyama–Kishi reaction , 2000 .
[183] Adam F. Littke,et al. Palladiumkatalysierte Kupplungen von Arylchloriden , 2002 .
[184] M Haniti S A Hamid,et al. Ruthenium-catalyzed N-alkylation of amines and sulfonamides using borrowing hydrogen methodology. , 2009, Journal of the American Chemical Society.
[185] M. Garneau,et al. Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335). , 2010, Journal of medicinal chemistry.
[186] J. Bäckvall,et al. Synthesis of a neonicotinoide pesticide derivative via chemoenzymatic dynamic kinetic resolution. , 2009, The Journal of organic chemistry.
[187] Thomas Weskamp,et al. A Novel Class of Ruthenium Catalysts for Olefin Metathesis. , 1998, Angewandte Chemie.
[188] H. Kagan,et al. An efficient asymmetric oxidation of sulfides to sulfoxides , 1984 .
[189] S. Buchwald,et al. Packed-bed reactors for continuous-flow C-N cross-coupling. , 2010, Angewandte Chemie.
[190] Y. Kishi,et al. Second generation synthesis of C27-C35 building block of E7389, a synthetic halichondrin analogue. , 2009, Organic letters.
[191] P. Beaulieu,et al. Development of a Pilot-Plant Process for a Nevirapine Analogue HIV NNRT Inhibitor , 2008 .
[192] K. Ishihara,et al. 3,5-Bis(perfluorodecyl)phenylboronic Acid as an Easily Recyclable Direct Amide Condensation Catalyst , 2001 .
[193] M. Palucki,et al. Development of a new and practical route to chiral 3,4-disubstituted cyclopentanones: asymmetric alkylation and intramolecular cyclopropanation as key C-C bond-forming steps. , 2002, The Journal of organic chemistry.
[194] E. Cragoe,et al. (Acylaryloxy)acetic acid diuretics. 2. (2-Alkyl-2-aryl-1-oxo-5-indanyloxy)acetic acids. , 1978, Journal of medicinal chemistry.
[195] H. Kagan,et al. Asymmetric oxidation of sulfides mediated by chiral titanium complexes : mechanistic and synthetic aspects , 1987 .
[196] R. Wiechert,et al. Neuartige asymmetrische Cyclisierung zu optisch aktiven Steroid‐CD‐Teilstücken , 1971 .
[197] A. Hoveyda,et al. Efficient and Recyclable Monomeric and Dendritic Ru-Based Metathesis Catalysts , 2000 .
[198] Richard A. Lerner,et al. Proline-Catalyzed Direct Asymmetric Aldol Reactions , 2000 .
[199] Jinkun Huang,et al. Olefin Metathesis-Active Ruthenium Complexes Bearing a Nucleophilic Carbene Ligand , 1999 .
[200] S. Denmark,et al. Lewis base activation of Lewis acids: catalytic enantioselective allylation and propargylation of aldehydes. , 2001, Journal of the American Chemical Society.
[201] C. Trombini,et al. Enantioselective synthesis of homo-allylic alcohols from chiral allylic tin(IV)(+)-diethyl tartrate complexes and aldehydes , 1986 .
[202] I. Beletskaya,et al. Palladium-catalyzed arylation of sulfonyl CH-acids , 2002 .
[203] C. Nakamura,et al. Metabolic engineering for the microbial production of 1,3-propanediol. , 2003, Current opinion in biotechnology.
[204] E. Corey,et al. Enantioselective synthesis of alpha-amino nitriles from N-benzhydryl imines and HCN with a chiral bicyclic guanidine as catalyst. , 1999, Organic letters.
[205] J. Muir,et al. Asymmetric enamide hydrogenation in the synthesis of N-acetylcolchinol: a key intermediate for ZD6126 , 2007 .
[206] Norio Miyaura,et al. Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds , 1995 .
[207] Jinhua J. Song,et al. Asymmetric synthesis of active pharmaceutical ingredients. , 2006, Chemical reviews.
[208] H. Ohmiya,et al. Directed ortho borylation of functionalized arenes catalyzed by a silica-supported compact phosphine-iridium system. , 2009, Journal of the American Chemical Society.
[209] C. Senanayake,et al. Reduction of tertiary phosphine oxides with DIBAL-H. , 2008, The Journal of organic chemistry.
[210] M. Krische,et al. anti-Diastereo- and enantioselective carbonyl crotylation from the alcohol or aldehyde oxidation level employing a cyclometallated iridium catalyst: alpha-methyl allyl acetate as a surrogate to preformed crotylmetal reagents. , 2009, Journal of the American Chemical Society.
[211] D. MacMillan,et al. The advent and development of organocatalysis , 2008, Nature.
[212] Xudong Wei,et al. Second-Generation Process for the HCV Protease Inhibitor BILN 2061: A Greener Approach to Ru-Catalyzed Ring-Closing Metathesis† , 2009 .
[213] N. Miyaura,et al. Mild iridium-catalyzed borylation of arenes. High turnover numbers, room temperature reactions, and isolation of a potential intermediate. , 2002, Journal of the American Chemical Society.
[214] Carl R. Johnson. Biotransformations in the Synthesis of Enantiopure Bioactive Molecules , 1998 .
[215] Martin Poirier,et al. NMR structural characterization of peptide inhibitors bound to the Hepatitis C virus NS3 protease: design of a new P2 substituent. , 2004, Journal of medicinal chemistry.
[216] B. Trost,et al. Regio- and Enantioselective Molybdenum-Catalyzed Alkylations of Polyenyl Esters , 1999 .
[217] M. Beller,et al. Eine effiziente und allgemeine Synthese primärer Amine durch Ruthenium‐katalysierte Aminierung sekundärer Alkohole mit Ammoniak , 2010 .
[218] C. Senanayake,et al. Oxaphosphole-Based Monophosphorus Ligands for Palladium-Catalyzed Amination Reactions , 2011 .
[219] M. Krische,et al. anti-Diastereo- and enantioselective carbonyl (hydroxymethyl)allylation from the alcohol or aldehyde oxidation level: allyl carbonates as allylmetal surrogates. , 2010, Journal of the American Chemical Society.
[220] A. Watson,et al. Ruthenium-catalyzed oxidation of alcohols into amides. , 2009, Organic letters.
[221] S. Blakey,et al. Enantioselective C-H amination using cationic ruthenium(II)-pybox catalysts. , 2008, Angewandte Chemie.
[222] K. Maruoka,et al. Enantioselective amino acid synthesis by chiral phase-transfer catalysis. , 2003, Chemical reviews.
[223] C. Senanayake,et al. Tandem Pd(II)-Catalyzed Vinyl Ether Exchange−Claisen Rearrangement as a Facile Approach to γ,δ-Unsaturated Aldehydes , 2007 .
[224] B. Pugin,et al. From a chiral switch to a ligand portfolio for asymmetric catalysis. , 2007, Accounts of chemical research.
[225] W. Knowles. Asymmetric Hydrogenations (Nobel Lecture 2001) , 2003 .
[226] F. Klingler. Asymmetric hydrogenation of prochiral amino ketones to amino alcohols for pharmaceutical use. , 2007, Accounts of chemical research.
[227] A. Phillips,et al. The halichondrins and E7389. , 2009, Chemical reviews.
[228] Jinhua J. Song,et al. Copper catalyzed asymmetric propargylation of aldehydes. , 2010, Journal of the American Chemical Society.
[229] C. Senanayake,et al. Directly probing the racemization of imidazolines by vibrational circular dichroism: kinetics and mechanism. , 2010, Organic Letters.
[230] B. M. Trost. Atomökonomische Synthesen – eine Herausforderung in der Organischen Chemie: die Homogenkatalyse als wegweisende Methode , 1995 .
[231] J. Hartwig. Regioselectivity of the borylation of alkanes and arenes. , 2011, Chemical Society reviews.
[232] T. Loh,et al. Silicon-assisted propargylic transfer to aldehydes. , 2004, Chemical communications.
[233] G. Bazan,et al. Synthesis of molybdenum imido alkylidene complexes and some reactions involving acyclic olefins , 1990 .
[234] S. Nagayama,et al. Chiral Lewis Acid Catalysis in Aqueous Media. Catalytic Asymmetric Aldol Reactions of Silyl Enol Ethers with Aldehydes in a Protic Solvent Including Water , 1999 .
[235] Jie Huang,et al. Development of a Nazarov cyclization/Wagner-Meerwein rearrangement sequence for the stereoselective synthesis of spirocycles. , 2007, Journal of the American Chemical Society.
[236] K. Mikami,et al. Super High Throughput Screening (SHTS) of Chiral Ligands and Activators: Asymmetric Activation of Chiral Diol-Zinc Catalysts by Chiral Nitrogen Activators for the Enantioselective Addition of Diethylzinc to Aldehydes. , 1999, Angewandte Chemie.
[237] B. Trost,et al. On inventing reactions for atom economy. , 2002, Accounts of chemical research.
[238] K. Manabe,et al. Development of novel Lewis acid catalysts for selective organic reactions in aqueous media. , 2002, Accounts of chemical research.
[239] Stephen L. Buchwald,et al. Eine einfache katalytische Methode zur Synthese von Arylaminen aus Arylbromiden , 1995 .
[240] Arcadi Antonio,et al. A versatile approach to 2,3-disubstituted indoles through the palladium-catalysed cyclization of o-alkynyltrifluoroacetanilides with vinyl triflates and aryl halides , 1992 .
[241] K. Nozaki,et al. Cationic BINAP-Ru(II) Halide Complexes: Highly Efficient Catalysts for Stereoselective Asymmetric Hydrogenation of .alpha.- and .beta.-Functionalized Ketones , 1994 .