An Automatic Method for Identifying Huntington's Disease using Gait Dynamics

Huntington's Disease (HD) is a genetic disorder that causes the progressive breakdown of nerve cells in the brain, reducing an individual's ability to reason, walk, and speak. Due to its severity, new approaches are important for the development of methods that contribute to the correct classification of this disease. In this paper, we propose an automatic method for diagnosing Huntington's Disease using gait dynamics information. Our approach is divided into a four-stage pipeline: preprocessing, feature extraction, classification, and diagnosis output. We evaluate the performance of our proposed method through well-known classifiers that are commonly used in machine learning problems. A publicly available database on Gait Dynamics in Neuro-Degenerative Disease is used, and the experimental results show that both Support Vector Machines (SVM) and Decision Tree (DT) were able to achieve an average accuracy of 100:0%, representing an improvement in the field.

[1]  David G. Stork,et al.  Pattern classification, 2nd Edition , 2000 .

[2]  Muhammad Hussain,et al.  Genetic feature selection for gait recognition , 2015, J. Electronic Imaging.

[3]  Giles M. Foody,et al.  A relative evaluation of multiclass image classification by support vector machines , 2004, IEEE Transactions on Geoscience and Remote Sensing.

[4]  J. Ross Quinlan,et al.  Induction of Decision Trees , 1986, Machine Learning.

[5]  Irina Rish,et al.  An empirical study of the naive Bayes classifier , 2001 .

[6]  S R Simon,et al.  Gait patterns in patients with amyotrophic lateral sclerosis. , 1984, Archives of physical medicine and rehabilitation.

[7]  Wei Zeng,et al.  Classification of neurodegenerative diseases using gait dynamics via deterministic learning , 2015, Inf. Sci..

[8]  Andreas Christmann,et al.  Support vector machines , 2008, Data Mining and Knowledge Discovery Handbook.

[9]  M. Arif,et al.  Complexity analysis of stride interval time series by threshold dependent symbolic entropy , 2006, European Journal of Applied Physiology.

[10]  Christopher M. Bishop,et al.  Pattern Recognition and Machine Learning (Information Science and Statistics) , 2006 .

[11]  Dinesh Kumar,et al.  Computing the variations in the self-similar properties of the various gait intervals in Parkinson disease patients , 2017, 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).