Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes

Summary.  Background:  Low fibrinogen levels are known to occur in trauma. However, the extent of fibrinogen depletion during trauma hemorrhage, the response to replacement therapy and association with patient outcomes remain unclear.

[1]  C. Thiemermann,et al.  Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations , 2010, Journal of thrombosis and haemostasis : JTH.

[2]  W. Voelckel,et al.  Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM®)-guided administration of fibrinogen concentrate and prothrombin complex concentrate , 2010, Critical care.

[3]  W. Voelckel,et al.  Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy , 2011, Critical care.

[4]  B. Allaouchiche,et al.  Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography , 2007, Journal of thrombosis and haemostasis : JTH.

[5]  J. Holcomb,et al.  Acidosis and Coagulopathy: The Differential Effects on Fibrinogen Synthesis and Breakdown in Pigs , 2007, Annals of surgery.

[6]  Eun-Seok Jeon,et al.  Extracorporeal cardiopulmonary resuscitation in patients with inhospital cardiac arrest: A comparison with conventional cardiopulmonary resuscitation* , 2011, Critical care medicine.

[7]  B. Sørensen,et al.  Fibrinogen concentrate for management of bleeding , 2011, Journal of thrombosis and haemostasis : JTH.

[8]  K. Brohi,et al.  Acute traumatic coagulopathy , 2012, Current opinion in anaesthesiology.

[9]  C. Hofer,et al.  Coagulation Monitoring: Current Techniques and Clinical Use of Viscoelastic Point-of-Care Coagulation Devices , 2008, Anesthesia and analgesia.

[10]  M. Hayakawa,et al.  Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortality. , 2009, Thrombosis research.

[11]  R. Rossaint,et al.  Effects of different fibrinogen concentrations on blood loss and coagulation parameters in a pig model of coagulopathy with blunt liver injury , 2010, Critical care.

[12]  W. Voelckel,et al.  Use of rotation thromboelastometry (ROTEM®) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate , 2010, Anaesthesia.

[13]  K. Inaba,et al.  FIBTEM provides early prediction of massive transfusion in trauma , 2011, Critical care.

[14]  S. Hiippala.  Replacement of Massive Blood Loss , 1998, Vox sanguinis.

[15]  M. Rotondo,et al.  Damage control resuscitation: the new face of damage control. , 2010, The Journal of trauma.

[16]  Karim Brohi,et al.  Functional definition and characterization of acute traumatic coagulopathy , 2011, Critical care medicine.

[17]  J. Ingerslev,et al.  Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations. , 2008, British journal of anaesthesia.

[18]  F. Stuber,et al.  Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. , 2008, The Journal of trauma.

[19]  P. Innerhofer,et al.  Prevalence and impact of abnormal ROTEM(R) assays in severe blunt trauma: results of the 'Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study'. , 2011, British journal of anaesthesia.

[20]  E. Samain,et al.  The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage , 2007, Journal of thrombosis and haemostasis : JTH.

[21]  Fiona Lecky,et al.  Recent massive blood transfusion practice in England and Wales: view from a trauma registry , 2011, Emergency Medicine Journal.

[22]  C. Wade,et al.  The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. , 2008, The Journal of trauma.

[23]  J. Vincent,et al.  Management of bleeding following major trauma: an updated European guideline , 2010, Critical care.

[24]  P. Hamilton,et al.  Guidelines on the management of massive blood loss , 2006, British journal of haematology.

[25]  S. Lewis,et al.  British Committee for Standards in Haematology , 1969 .