Design of Physicians' Health Study II--a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials.

[1]  J. Manson,et al.  β‐carotene supplementation for patients with low baseline levels and decreased risks of total and prostate carcinoma , 1999, Cancer.

[2]  J. Manson,et al.  Prospective cohort study of antioxidant vitamin supplement use and the risk of age-related maculopathy. , 1999, American journal of epidemiology.

[3]  P. Galan,et al.  Background and rationale behind the SU.VI.MAX Study, a prevention trial using nutritional doses of a combination of antioxidant vitamins and minerals to reduce cardiovascular diseases and cancers. SUpplementation en VItamines et Minéraux AntioXydants Study. , 1998, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[4]  J. Buring,et al.  Antioxidant vitamins and cardiovascular disease. , 2009, Nutrition reviews.

[5]  R. Klein,et al.  Association of zinc and antioxidant nutrients with age-related maculopathy. , 1996, Archives of ophthalmology.

[6]  G. Omenn,et al.  Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. , 1996, The New England journal of medicine.

[7]  J. Manson,et al.  Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. , 1996, The New England journal of medicine.

[8]  F. Kelly,et al.  Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS) , 1996, The Lancet.

[9]  Janzen,et al.  The HOPE (Heart Outcomes Prevention Evaluation) Study: the design of a large, simple randomized trial of an angiotensin-converting enzyme inhibitor (ramipril) and vitamin E in patients at high risk of cardiovascular events. The HOPE study investigators. , 1996, The Canadian journal of cardiology.

[10]  T. Byers,et al.  Epidemiologic evidence for vitamin C and vitamin E in cancer prevention. , 1995, The American journal of clinical nutrition.

[11]  S. Yusuf,et al.  The Antioxidant Vitamins and Cardiovascular Disease: A Critical Review of Epidemiologic and Clinical Trial Data , 1995, Annals of Internal Medicine.

[12]  R. Klein,et al.  Serum antioxidants and age-related macular degeneration in a population-based case-control study. , 1995, Archives of ophthalmology.

[13]  M. C. Leske,et al.  Biochemical factors in the lens opacities. Case-control study. The Lens Opacities Case-Control Study Group. , 1995, Archives of ophthalmology.

[14]  J. Manson,et al.  A secondary prevention trial of antioxidant vitamins and cardiovascular disease in women. Rationale, design, and methods. The WACS Research Group. , 1995, Annals of epidemiology.

[15]  G A Colditz,et al.  A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly. , 1995, Annals of epidemiology.

[16]  R. Klein,et al.  Diet and nuclear lens opacities. , 1995, American journal of epidemiology.

[17]  M Palta,et al.  Serum carotenoids and tocopherols and severity of nuclear and cortical opacities. , 1995, Investigative ophthalmology & visual science.

[18]  Lawrence A. Yannuzzi,et al.  Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration , 1994 .

[19]  R Hiller,et al.  Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. , 1994, JAMA.

[20]  J. Manson,et al.  The use of vitamin supplements and the risk of cataract among US male physicians. , 1994, American journal of public health.

[21]  B. Munoz,et al.  Are antioxidants or supplements protective for age-related macular degeneration? , 1994, Archives of ophthalmology.

[22]  R. Klein,et al.  Relation between lens opacities and vitamin and mineral supplement use. , 1994, Ophthalmology.

[23]  B. Frei.  Natural antioxidants in human health and disease , 1994 .

[24]  J. Manson,et al.  13 – Natural Antioxidants and Cardiovascular Disease: Observational Epidemiologic Studies and Randomized Trials , 1994 .

[25]  D. Albanes,et al.  The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. , 1994, The New England journal of medicine.

[26]  J. Loscalzo,et al.  Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[27]  M. Gail,et al.  Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. , 1993, Journal of the National Cancer Institute.

[28]  J. Manson,et al.  Vitamin E consumption and the risk of coronary disease in women. , 1993, The New England journal of medicine.

[29]  E. Rimm,et al.  Vitamin E consumption and the risk of coronary heart disease in men. , 1993, The New England journal of medicine.

[30]  F Wang,et al.  Plasma Antioxidants and Risk of Cortical and Nuclear Cataract , 1993, Epidemiology.

[31]  H. Esterbauer,et al.  The role of lipid peroxidation and antioxidants in oxidative modification of LDL. , 1992, Free radical biology & medicine.

[32]  A. Taylor,et al.  Role of Nutrients in Delaying Cataracts a , 1992, Annals of the New York Academy of Sciences.

[33]  P. Knekt.  Vitamin E and Cancer: Epidemiology , 1992, Annals of the New York Academy of Sciences.

[34]  B Rosner,et al.  Nutrient intake and cataract extraction in women: a prospective study. , 1992, BMJ.

[35]  D. Steinberg.  Antioxidants in the prevention of human atherosclerosis. Summary of the proceedings of a National Heart, Lung, and Blood Institute Workshop: September 5-6, 1991, Bethesda, Maryland. , 1992, Circulation.

[36]  J. Enstrom,et al.  Vitamin C Intake and Mortality among a Sample of the United States Population , 1992, Epidemiology.

[37]  N. Brown,et al.  The lens opacities case-control study. , 1991, Archives of ophthalmology.

[38]  N. Cook,et al.  Estimating the effect of the run-in on the power of the Physicians' Health Study. , 1991, Statistics in medicine.

[39]  L T Chylack,et al.  The Lens Opacities Case-Control Study. Risk factors for cataract. , 1991, Archives of ophthalmology.

[40]  R. Pew,et al.  Vitamin E and cancer , 1991 .

[41]  G. Block,et al.  Vitamin C and cancer prevention: the epidemiologic evidence. , 1991, The American journal of clinical nutrition.

[42]  K. Helzlsouer,et al.  Prediagnostic serum levels of carotenoids and vitamin E as related to subsequent cancer in Washington County, Maryland. , 1991, The American journal of clinical nutrition.

[43]  L. Breimer.  Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage , 2006, Molecular carcinogenesis.

[44]  F. Ferris,et al.  Do we have a nutritional treatment for age-related cataract or macular degeneration? , 1990, Archives of ophthalmology.

[45]  M. Marcus,et al.  Determination of right ventricular mass in humans and dogs with ultrafast cardiac computed tomography. , 1990, Circulation.

[46]  B. Modan,et al.  Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies. , 1990, Journal of the National Cancer Institute.

[47]  R. Elton,et al.  Plasma antioxidants and coronary heart disease: vitamins C and E, and selenium. , 1990, European journal of clinical nutrition.

[48]  J. Trevithick,et al.  Vitamin E Intake and Risk of Cataracts in Humans a , 1989, Annals of the New York Academy of Sciences.

[49]  M. Tso.  Experiments on visual cells by nature and man: in search of treatment for photoreceptor degeneration. Friedenwald lecture. , 1989, Investigative ophthalmology & visual science.

[50]  R. Milton,et al.  India-US case-control study of age-related cataracts. India-US Case-Control Study Group. , 1989, Archives of ophthalmology.

[51]  J L Witztum,et al.  Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. , 1989, The New England journal of medicine.

[52]  H. Gerster.  Antioxidant vitamins in cataract prevention , 1989, Zeitschrift fur Ernahrungswissenschaft.

[53]  J. Brody,et al.  FACTORS ASSOCIATED WITH AGE-RELATED MACULAR DEGENERATION AN ANALYSIS OF DATA FROM THE FI1R8T NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY , 1988 .

[54]  L T Chylack,et al.  Nutritional status in persons with and without senile cataract: blood vitamin and mineral levels. , 1988, The American journal of clinical nutrition.

[55]  O. Yoshida,et al.  Dietary beta-carotene and cancer of the prostate: a case-control study in Kyoto, Japan. , 1988, Cancer research.

[56]  L. Marnett,et al.  Peroxyl free radicals: potential mediators of tumor initiation and promotion. , 1987, Carcinogenesis.

[57]  W. Yamanaka.  Vitamins and cancer prevention. How much do we know? , 1987, Postgraduate medicine.

[58]  E. Niki,et al.  Antioxidants in relation to lipid peroxidation. , 1987, Chemistry and physics of lipids.

[59]  B. Henderson,et al.  Case-control studies of prostate cancer in blacks and whites in southern California. , 1987, Journal of the National Cancer Institute.

[60]  H. Stähelin,et al.  Plasma levels of antioxidant vitamins in relation to ischemic heart disease and cancer. , 1987, The American journal of clinical nutrition.

[61]  A. Hofman,et al.  Serum selenium, vitamin antioxidants, and cardiovascular mortality: a 9-year follow-up study in the Netherlands. , 1987, The American journal of clinical nutrition.

[62]  M. Tso,et al.  The protective effect of ascorbate in retinal light damage of rats. , 1985, Investigative ophthalmology & visual science.

[63]  J. Salonen,et al.  Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery disease. , 1985, The American journal of cardiology.

[64]  C. Hennekens,et al.  A randomized trial of aspirin and β-carotene among U.S. physicians , 1985 .

[65]  J. Kapeghian,et al.  Fruit and vegetable consumption and cardiovascular mortality. , 1985, Medical hypotheses.

[66]  W. Willett,et al.  Increased green and yellow vegetable intake and lowered cancer deaths in an elderly population. , 1985, The American journal of clinical nutrition.

[67]  C. Hennekens,et al.  Issues in the design and conduct of clinical trials. , 1984, Journal of the National Cancer Institute.

[68]  W. T. Ham,et al.  Basic mechanisms underlying the production of photochemical lesions in the mammalian retina. , 1984, Current eye research.

[69]  S. Vollset,et al.  DOES CONSUMPTION OF FRUIT AND VEGETABLES PROTECT AGAINST STROKE? , 1983, The Lancet.

[70]  E. Bright-See.  Vitamin C and cancer prevention. , 1983, Seminars in oncology.

[71]  R. Acheson,et al.  DOES CONSUMPTION OF FRUIT AND VEGETABLES PROTECT AGAINST STROKE? , 1983, The Lancet.

[72]  J. Hankin,et al.  Role of diet in cancer incidence in Hawaii. , 1983, Cancer research.

[73]  S. Graham.  Results of case-control studies of diet and cancer in Buffalo, New York. , 1983, Cancer research.

[74]  V. Devita,et al.  Cancer : Principles and Practice of Oncology , 1982 .

[75]  Jeremiah Stamler,et al.  DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY , 1981, The Lancet.

[76]  R. Priore,et al.  Dietary factors in the epidemiology of cancer of the larynx. , 1981, American journal of epidemiology.

[77]  M. Sporn,et al.  Can dietary beta-carotene materially reduce human cancer rates? , 1981, Nature.

[78]  E. Ginter.  Decline of coronary mortality in United States and vitamin C. , 1979, The American journal of clinical nutrition.

[79]  A. Adelstein,et al.  Commodity consumption and ischemic heart disease mortality, with special reference to dietary practices. , 1975, Journal of chronic diseases.

[80]  Baron Jh.  Letter: Peptic ulcer. , 1975 .

[81]  Tappel Al.  Lipid peroxidation damage to cell components. , 1973 .

[82]  Williams Ln,et al.  PROGNOSIS AND DISABLEMENT PENSIONS. , 1964 .

[83]  R. B. Slocum,et al.  Manual of procedures , 1959 .