论文信息 - DRUG SOLUBILITY : IMPORTANCE AND ENHANCEMENT TECHNIQUES

DRUG SOLUBILITY : IMPORTANCE AND ENHANCEMENT TECHNIQUES

1.INTRODUCTION The solubility of a compound depends on its structure and solution conditions. Structure determines the lipophilicity, hydrogen bonding, molecular volume, crystal energy and ionizability, which determine solubility. Solution conditions are affected by pH, cosolvents, additives, ionic strength, time and temperature. Poorly soluble compounds can dramatically reduce productivity in drug discovery and development.

Pilar Ventosa-Andrés | Yolanda Fernández Gadea | Yolanda Fernández Gadea

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