论文信息 - Surface Plasmon Resonance Biosensor Incorporated in a Michelson Interferometer WithEnhanced Sensitivity

Surface Plasmon Resonance Biosensor Incorporated in a Michelson Interferometer WithEnhanced Sensitivity

A novel double-pass phase-sensitive surface plasmon resonance (SPR) biosensor based on a Michelson interferometer with differential phase interrogation is presented. The new setup provides an intrinsic resolution enhancement of up to two times in terms of achievable detection sensitivity due to an amplification effect in the SPR phase change when we place the SPR sensor head in the signal arm of the interferometer so that the interrogating optical beam traverses the sensor surface twice. Experimental results obtained from saltwater mixtures and antibody-antigen binding reactions confirmed the expected sensitivity enhancement as compared to the conventional SPR biosensor based on a Mach-Zehnder interferometer

[1] Petr I. Nikitin,et al. Surface plasmon resonance interferometer for bio- and chemical-sensors , 1998 .

[2] Timothy M. Chinowsky,et al. Performance of the Spreeta 2000 integrated surface plasmon resonance affinity sensor , 2003 .

[3] H. Raether. Surface Plasmons on Smooth and Rough Surfaces and on Gratings , 1988 .

[4] R. Rich,et al. Survey of the year 2004 commercial optical biosensor literature , 2005, Journal of molecular recognition : JMR.

[5] J Guo,et al. Optical phase-shift detection of surface plasmon resonance. , 1998, Applied optics.

[6] Chien‐Ming Wu,et al. Sensitivity-tunable optical sensors based on surface plasmon resonance and phase detection. , 2004, Optics express.

[7] J. Villatoro,et al. Sensitivity of optical sensors based on laser-excited surface-plasmon waves. , 1999, Applied optics.

[8] Günter Gauglitz,et al. Surface plasmon resonance sensors: review , 1999 .

[9] Petr I. Nikitin,et al. Surface plasmon resonance interferometry for micro-array biosensing , 2000 .

[10] Chinlon Lin,et al. Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach-Zehnder configuration. , 2004, Optics letters.

[11] Jiří Homola,et al. Multichannel surface plasmon resonance biosensor with wavelength division multiplexing , 2005 .

[12] E. Kretschmann,et al. Notizen: Radiative Decay of Non Radiative Surface Plasmons Excited by Light , 1968 .