Brain activation to favorite music in healthy controls and depressed patients

Reward-processing neurocircuitry has been delineated using verbal or visual processing and/or decision-making tasks. We examined more basic processes of listening to enjoyable music in healthy and depressed patients. The paradigm was passive, individualized, and brief. Sixteen depressed and 15 control individuals provided favorite music and identified neutral music from selections provided. In the fMRI scanner, individuals heard their neutral and their favorite music for 3 min each. Favorite versus neutral music-listening contrasts showed greater activation in controls than depressed patients in medial orbital frontal cortex and nucleus accumbens/ventral striatum. Left medial prefrontal cortex activity was positively correlated with pleasure scores, whereas middle temporal cortex and globus pallidus were negatively correlated with pleasure. This paradigm activated neurocircuitry of reward processing and showed clinically meaningful alterations in depression.

[1]  Sandra Jazbec,et al.  Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents , 2005, NeuroImage.

[2]  A. Young,et al.  A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder , 2005, Biological Psychiatry.

[3]  A. Beck,et al.  An inventory for measuring depression. , 1961, Archives of general psychiatry.

[4]  Yihong Yang,et al.  Lack of ventral striatal response to positive stimuli in depressed versus normal subjects. , 2006, The American journal of psychiatry.

[5]  Karl J. Friston,et al.  Dissociable Neural Responses in Human Reward Systems , 2000, The Journal of Neuroscience.

[6]  Mary L. Phillips,et al.  A Double Dissociation of Ventromedial Prefrontal Cortical Responses to Sad and Happy Stimuli in Depressed and Healthy Individuals , 2005, Biological Psychiatry.

[7]  Klaus P. Ebmeier,et al.  Cognitive function in major depression. , 1992, Journal of affective disorders.

[8]  S. Rauch,et al.  Neurobiology of emotion perception II: implications for major psychiatric disorders , 2003, Biological Psychiatry.

[9]  R. Elliott,et al.  Abnormal neural response to feedback on planning and guessing tasks in patients with unipolar depression , 1998, Psychological Medicine.

[10]  R. Dahl,et al.  Alterations in Reward-Related Decision Making in Boys with Recent and Future Depression , 2007, Biological Psychiatry.

[11]  Paul J. Laurienti,et al.  An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets , 2003, NeuroImage.

[12]  P. Mazzoni,et al.  Anhedonia after a selective bilateral lesion of the globus pallidus. , 2006, The American journal of psychiatry.

[13]  R. Zatorre,et al.  Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Gregor Hasler,et al.  Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects. , 2008, Archives of general psychiatry.

[15]  Peter Muris,et al.  The assessment of anhedonia in clinical and non-clinical populations: further validation of the Snaith-Hamilton Pleasure Scale (SHAPS). , 2007, Journal of affective disorders.

[16]  Daniel J. Levitin,et al.  The rewards of music listening: Response and physiological connectivity of the mesolimbic system , 2005, NeuroImage.

[17]  A. Hariri,et al.  Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder. , 2009, The American journal of psychiatry.

[18]  Mark S. George,et al.  Regional cerebral metabolism associated with anxiety symptoms in affective disorder patients , 2000, Biological Psychiatry.

[19]  Dirk J. Heslenfeld,et al.  Activity in human reward-sensitive brain areas is strongly context dependent , 2005, NeuroImage.

[20]  Steven C. R. Williams,et al.  The Neural Correlates of Anhedonia in Major Depressive Disorder , 2005, Biological Psychiatry.

[21]  W. Drevets,et al.  Orbitofrontal Cortex Function and Structure in Depression , 2007, Annals of the New York Academy of Sciences.

[22]  R. Elliott,et al.  Medial orbitofrontal cortex codes relative rather than absolute value of financial rewards in humans , 2008, The European journal of neuroscience.

[23]  J. Pruessner,et al.  Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in non-clinical subjects , 2007, Molecular Psychiatry.

[24]  E. Rolls,et al.  Abstract reward and punishment representations in the human orbitofrontal cortex , 2001, Nature Neuroscience.