Report on the risk assessment of mephedrone in the framework of the Council Decision on new psychoactive substances.

This publication presents the summary findings and the conclusions of the risk assessment on mephedrone, carried out by the EMCDDA’s extended Scientific Committee, with participation of additional experts from the European Commission, Europol and the EMA. The risk assessment report, which was submitted to the European Commission and the Council of the European Union 26 May 2010, examines the health and social risks of the drug, as well as information on international trafficking and the involvement of organised crime. Furthermore, the report considers the potential implications for placing the drug under control in the EU. On the basis of this report — and on the initiative of the European Commission — on 2 December 2010, the Council decided that mephedrone is to be subject to control measures. Table of contents: • Introduction • Physical and chemical description of mephedrone and its mechanisms of action, including its medical value • Chemical precursors that are used for the manufacture of mephedrone • Health risks associated with mephedrone • Social risks associated with mephedrone • Information on the level of involvement of organised crime and information on seizures and/or detections by the authorities, and the manufacture of mephedrone • Information on any assessment of mephedrone in the United Nations system • Description of the control measures that are applicable to mephedrone in the Member States • Options for control and the possible consequences of the control measures • Conclusion • List of annexes

[1]  M. Johnston,et al.  Chemical analysis of four capsules containing the controlled substance analogues 4-methylmethcathinone, 2-fluoromethamphetamine, alpha-phthalimidopropiophenone and N-ethylcathinone. , 2010, Forensic science international.

[2]  A. Winstock,et al.  Mephedrone, new kid for the chop? , 2011, Addiction.

[3]  S. Wylie,et al.  Dependence and psychosis with 4-methylmethcathinone (mephedrone) use , 2010, BMJ Case Reports.

[4]  Mike Power Mephedrone: the future of drug dealing? , 2010 .

[5]  A. Winstock,et al.  Drugs and the dance music scene: a survey of current drug use patterns among a sample of dance music enthusiasts in the UK. , 2001, Drug and alcohol dependence.

[6]  S. Stokes,et al.  Head shop compound abuse amongst attendees of the Drug Treatment Centre Board. , 2010, Irish medical journal.

[7]  Daniel Angelov,et al.  The Characterization of 'Legal Highs' Available from Head Shops in Dublin , 2010 .

[8]  B. Levine,et al.  Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroin. , 2010, Journal of analytical toxicology.

[9]  C. Escher,et al.  [Mephedrone--Internet drug which seems to have come and stay. Fatal cases in Sweden have drawn attention to previously unknown substance]. , 2009, Lakartidningen.

[10]  P. Dargan,et al.  Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone , 2010, Emergency Medicine Journal.

[11]  Anneke Poortman,et al.  Instability of the ecstasy market and a new kid on the block: mephedrone , 2011, Journal of psychopharmacology.

[12]  Olivier Roussel,et al.  La 4-méthyléphédrone sera-t-elle une "Ecstasy" du XXIème siècle ? , 2009 .

[13]  Kelly Morris,et al.  UK places generic ban on mephedrone drug family , 2010, The Lancet.

[14]  Frank T Peters,et al.  Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography–mass spectrometry , 2010, Analytical and bioanalytical chemistry.

[15]  J. Ramsey,et al.  Legal highs and the challenges for policy makers , 2010 .

[16]  M. Zloh,et al.  An analysis of the 'legal high' mephedrone. , 2010, Bioorganic & medicinal chemistry letters.

[17]  Fiona Measham,et al.  Tweaking, bombing, dabbing and stockpiling: the emergence of mephedrone and the perversity of prohibition , 2010 .

[18]  David W. Holt,et al.  Recreational Use of Mephedrone (4-Methylmethcathinone, 4-MMC) with Associated Sympathomimetic Toxicity , 2010, Journal of Medical Toxicology.

[19]  A. Winstock,et al.  Five-year trends in patterns of drug use among people who use stimulants in dance contexts in the United Kingdom. , 2005, Addiction.

[20]  P. Dargan,et al.  Mephedrone use and associated adverse effects in school and college/university students before the UK legislation change. , 2010, QJM : monthly journal of the Association of Physicians.

[21]  John Marsden,et al.  What should be done about mephedrone? , 2010, BMJ : British Medical Journal.