A Cambridge Structural Database analysis of the C–H⋯Cl interaction: C–H⋯Cl− and C–H⋯Cl–M often behave as hydrogen bonds but C–H⋯Cl–C is generally a van der Waals interaction

A survey of organic crystal structures in the CSD for C–H⋯Cl contacts with Cl–M, Cl− and Cl–C acceptor moieties shows the inverse distance–angle correlation characteristic of a hydrogen bond for C–H⋯Cl–M and C–H⋯Cl− type interactions. The d–θ scatter plot for the C–H⋯Cl–C interaction has many points in the van der Waals region. Further, the H⋯Cl bond is shorter with activated donors for Cl–M and Cl− acceptors but not for Cl–C. These frequency data may be useful to classify C–H⋯Cl interactions as hydrogen bonds or van der Waals interactions in crystal structure analysis.

[1]  Madhavi,et al.  Crystal engineering in the gem-alkynol family: interplay between strong and weak interactions in structures of 2,3,5,6-tetrahalo , 2000, Acta crystallographica. Section B, Structural science.

[2]  Corradi,et al.  Halogen Bonding versus Hydrogen Bonding in Driving Self-Assembly Processes Perfluorocarbon-hydrocarbon self-assembly, part IX. This work was supported by MURST (Cofinanziamento '99) and EU (COST-D12-0012). We thank Dr. A. Lunghi and Dr. P. Cardillo (Stazione Sperimentale Combustibili, S. Donato Mila , 2000, Angewandte Chemie.

[3]  R. Davey,et al.  Br···Br and Br···H Interactions in Action: Polymorphism, Hopping, and Twinning in 1,2,4,5-Tetrabromobenzene , 2000 .

[4]  Gautam R. Desiraju,et al.  The Weak Hydrogen Bond: In Structural Chemistry and Biology , 1999 .

[5]  P. Metrangolo,et al.  Resolution of Racemic 1,2-Dibromohexafluoropropane through Halogen-Bonded Supramolecular Helices. , 1999, Angewandte Chemie.

[6]  D. Braga,et al.  Inorganic–organometallic crystal synthesis. The role of charge-assisted C–H…O and C–H…Cl hydrogen bonds in crystalline [(η5-C5H5)2Co][H2PO4]·3H2O and [(η6-C6H5Me)2Cr][Cl] , 1999 .

[7]  G. Desiraju,et al.  C−H···F Interactions in the Crystal Structures of Some Fluorobenzenes , 1998 .

[8]  J. Scholz,et al.  (1,4‐Diaza‐1,3‐diene)titanium and ‐niobium Halides: Unusual Structures with Intramolecular C−H⋅⋅⋅Halogen Hydrogen Bonds , 1998 .

[9]  T. Steiner Hydrogen-Bond Distances to Halide Ions in Organic and Organometallic Crystal Structures: Up-to-date Database Study , 1998 .

[10]  J. Bernstein,et al.  Chains, Ladders, and Two‐Dimensional Sheets with Halogen ċ Halogen and Halogen ċ Hydrogen Interactions , 1997 .

[11]  Frank H. Allen,et al.  The Nature and Geometry of Intermolecular Interactions between Halogens and Oxygen or Nitrogen , 1996 .

[12]  A. Stone,et al.  The Nature of -Cl.cntdot..cntdot..cntdot.Cl- Intermolecular Interactions , 1994 .

[13]  G. Desiraju,et al.  The nature of halogen.cntdot..cntdot..cntdot.halogen interactions: are short halogen contacts due to specific attractive forces or due to close packing of nonspherical atoms? , 1989 .

[14]  Olga Kennard,et al.  Crystallographic evidence for the existence of CH.cntdot..cntdot..cntdot.O, CH.cntdot..cntdot..cntdot.N and CH.cntdot..cntdot..cntdot.Cl hydrogen bonds , 1982 .

[15]  F. H. Cano,et al.  Balance of forces between various contacts in crystal structures of two isomeric benzo‐condensed dibromodihydroxy‐containing compounds , 2000 .

[16]  M. Freytag,et al.  Hydrogen bonds C–H⋯Cl as astructure-determining factor in the gold(I) complexbis(3-bromopyridine)gold(I)dichloroaurate(I) , 2000 .

[17]  I. Pálinkó,et al.  The C-H...Cl hydrogen bond: Does it exist? , 1999 .

[18]  L. Brammer,et al.  Fluoride ligands exhibit marked departures from the hydrogen bond acceptor behavior of their heavier halogen congeners , 1999 .

[19]  A. Guy Orpen,et al.  Metal-bound chlorine often accepts hydrogen bonds , 1998 .

[20]  B. Ahrens,et al.  Bis(diphenylphosphino)methane and related ligands as hydrogen bond donors , 1998 .

[21]  T. Steiner Donor and acceptor strengths in C–H···O hydrogen bonds quantified from crystallographic data of small solvent molecules , 1998 .

[22]  Robin Taylor,et al.  Organic Fluorine Hardly Ever Accepts Hydrogen Bonds , 1997 .

[23]  M. Mascal A statistical analysis of halide · · · H–A (A = OR, NR2, N+R3) hydrogen bonding interactions in the solid state , 1997 .