Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice.

[1]  N. Lehwald,et al.  Notch 1 tumor expression is lacking in highly proliferative pancreatic neuroendocrine tumors , 2013, Endocrine.

[2]  A. Maitra,et al.  Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer. , 2013, Cancer letters.

[3]  A. Arlt,et al.  Targeting apoptosis pathways in pancreatic cancer. , 2013, Cancer letters.

[4]  S. Roy,et al.  GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. , 2013, Cancer letters.

[5]  Yinmo Yang,et al.  Hedgehog signaling pathway regulates human pancreatic cancer cell proliferation and metastasis. , 2013, Oncology reports.

[6]  Donald J L Jones,et al.  Notch3 and Hey-1 as Prognostic Biomarkers in Pancreatic Adenocarcinoma , 2012, PloS one.

[7]  S. Shankar,et al.  Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog–GLI pathway , 2012, Molecular and Cellular Biochemistry.

[8]  Bechien U. Wu,et al.  Genetic Markers of Malignant Transformation in Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Meta-Analysis , 2012, Pancreas.

[9]  S. Shankar,et al.  Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal , 2012, PloS one.

[10]  L. Soane,et al.  A New View of the Lethal Apoptotic Pore , 2012, PLoS biology.

[11]  M. Ullah,et al.  Celecoxib and GABA Cooperatively Prevent the Progression of Pancreatic Cancer In Vitro and in Xenograft Models of Stress-Free and Stress-Exposed Mice , 2012, PloS one.

[12]  L. Tran,et al.  Cell Intrinsic Role of COX-2 in Pancreatic Cancer Development , 2012, Molecular Cancer Therapeutics.

[13]  Duane H. Hamilton,et al.  Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment. , 2012, Future oncology.

[14]  S. Shankar,et al.  Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics , 2012, International journal of cancer.

[15]  J. Jensen,et al.  Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells , 2012, Development.

[16]  T. Brabletz To differentiate or not — routes towards metastasis , 2012, Nature Reviews Cancer.

[17]  F. Sarkar,et al.  The Tyrosine Kinase c-Src Directly Mediates Growth Factor-Induced Notch-1 and Furin Interaction and Notch-1 Activation in Pancreatic Cancer Cells , 2012, PloS one.

[18]  C. Wright,et al.  Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. , 2012, Developmental biology.

[19]  A. Durczyński,et al.  Prostaglandin E2 (PGE2) in Portal Blood in Patients with Pancreatic Tumor—A Single Institution Series , 2012, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[20]  S. Shankar,et al.  Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) Inhibits Pancreatic Cancer Stem Cell Characteristics: Molecular Mechanisms , 2011, PloS one.

[21]  Y. Seong,et al.  ZSTK474, a PI3K inhibitor, suppresses proliferation and sensitizes human pancreatic adenocarcinoma cells to gemcitabine. , 2011, Oncology reports.

[22]  P. Adams,et al.  Ras, PI3K/Akt and senescence , 2011, Small GTPases.

[23]  Marianne D. Castillo,et al.  IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. , 2011, Cancer research.

[24]  G. Sudhandiran,et al.  Ellagic acid prevents rat colon carcinogenesis induced by 1, 2 dimethyl hydrazine through inhibition of AKT-phosphoinositide-3 kinase pathway. , 2011, European journal of pharmacology.

[25]  N. Jamieson,et al.  Tissue Biomarkers for Prognosis in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis , 2011, Clinical Cancer Research.

[26]  K. Pavelić,et al.  Metastasis: new perspectives on an old problem , 2011, Molecular Cancer.

[27]  S. Shankar,et al.  Resveratrol Inhibits Pancreatic Cancer Stem Cell Characteristics in Human and KrasG12D Transgenic Mice by Inhibiting Pluripotency Maintaining Factors and Epithelial-Mesenchymal Transition , 2011, PloS one.

[28]  S. Dry,et al.  PTEN loss accelerates KrasG12D-induced pancreatic cancer development. , 2010, Cancer research.

[29]  Jun Yao,et al.  Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Akt-dependent pathway , 2010, Medical oncology.

[30]  S. Shankar,et al.  The dietary bioflavonoid quercetin synergizes with epigallocathechin gallate (EGCG) to inhibit prostate cancer stem cell characteristics, invasion, migration and epithelial-mesenchymal transition , 2010, Journal of molecular signaling.

[31]  J. Merchant,et al.  Hedgehog signaling and gastrointestinal cancer. , 2010, Biochimica et biophysica acta.

[32]  A. Iafrate,et al.  Novel Xenograft and Cell Line Derived From an Invasive Intraductal Papillary Mucinous Neoplasm of the Pancreas Give New Insights Into Molecular Mechanisms , 2010, Pancreas.

[33]  M. Singer,et al.  Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma , 2010, International journal of environmental research and public health.

[34]  G. Semenza HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery. , 2009, Current pharmaceutical design.

[35]  Zhiwei Wang,et al.  Pancreatic cancer stem cells and EMT in drug resistance and metastasis. , 2009, Minerva chirurgica.

[36]  N. McCarthy Metastasis: Route master , 2009, Nature Reviews Cancer.

[37]  N. McCarthy Metastasis: Influencing bad behaviour , 2009, Nature Reviews Cancer.

[38]  Sarah E. Seton-Rogers Tumour suppressors: Different roads to inactivation , 2009, Nature Reviews Cancer.

[39]  D. Jenkins Hedgehog signalling: emerging evidence for non-canonical pathways. , 2009, Cellular signalling.

[40]  L. C. Murtaugh,et al.  Notch and Kras in pancreatic cancer: At the crossroads of mutation, differentiation and signaling , 2009, Cell cycle.

[41]  E. Neilson,et al.  Biomarkers for epithelial-mesenchymal transitions. , 2009, The Journal of clinical investigation.

[42]  M. Nieto,et al.  Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. , 2009, The Journal of clinical investigation.

[43]  Paula D. Bos,et al.  Metastasis: from dissemination to organ-specific colonization , 2009, Nature Reviews Cancer.

[44]  V. Go,et al.  Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer cells. , 2008, World journal of gastroenterology.

[45]  M. Mutanen,et al.  Chemoprevention by white currant is mediated by the reduction of nuclear β-catenin and NF-κB levels in Min mice adenomas , 2008, European journal of nutrition.

[46]  G. Fong Mechanisms of adaptive angiogenesis to tissue hypoxia , 2008, Angiogenesis.

[47]  M. Scott,et al.  Patching the gaps in Hedgehog signalling , 2007, Nature Cell Biology.

[48]  F. Radtke,et al.  Notch and cancer: a double-edged sword , 2007, Cellular and Molecular Life Sciences.

[49]  M. Singer,et al.  Effect of Non-Alcoholic Compounds of Alcoholic Drinks on the Pancreas , 2007, Pancreatology.

[50]  P. Steeg Tumor metastasis: mechanistic insights and clinical challenges , 2006, Nature Medicine.

[51]  G. Semenza,et al.  Regulation of angiogenesis by hypoxia-inducible factor 1. , 2006, Critical reviews in oncology/hematology.

[52]  R. Hruban,et al.  A new mouse model of pancreatic cancer: PTEN gets its Akt together. , 2005, Cancer cell.

[53]  S. Shankar,et al.  Effects of sequential treatments with chemotherapeutic drugs followed by TRAIL on prostate cancer in vitro and in vivo , 2005, The Prostate.

[54]  A. Giaccia,et al.  Hypoxic gene expression and metastasis , 2004, Cancer and Metastasis Reviews.

[55]  Lawrence Lum,et al.  The Hedgehog Response Network: Sensors, Switches, and Routers , 2004, Science.

[56]  Suzanne Cory,et al.  The Bcl-2 family: roles in cell survival and oncogenesis , 2003, Oncogene.

[57]  Gregory Y. Lauwers,et al.  Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis , 2003, Nature.

[58]  J. Folkman Angiogenesis and proteins of the hemostatic system , 2003, Journal of thrombosis and haemostasis : JTH.

[59]  L. Benjamin,et al.  Angiogenesis: Tumorigenesis and the angiogenic switch , 2003, Nature Reviews Cancer.

[60]  P. Ratcliffe,et al.  Regulation of angiogenesis by hypoxia: role of the HIF system , 2003, Nature Medicine.

[61]  J. Folkman Role of angiogenesis in tumor growth and metastasis. , 2002, Seminars in oncology.

[62]  J. Neoptolemos,et al.  Surgical and medical therapy for pancreatic carcinoma. , 2002, Best practice & research. Clinical gastroenterology.

[63]  Donghui Li,et al.  Molecular epidemiology of pancreatic cancer , 2001, International journal of gastrointestinal cancer.

[64]  P Vaupel,et al.  Biological consequences of tumor hypoxia. , 2001, Seminars in oncology.

[65]  C. Thompson,et al.  The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability , 2000, Cell Death and Differentiation.

[66]  Matthew G. Vander Heiden,et al.  Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis? , 1999, Nature Cell Biology.

[67]  Jessica Lo,et al.  HIF‐1α is required for solid tumor formation and embryonic vascularization , 1998 .

[68]  R. Kuttan,et al.  Inhibition of liver fibrosis by ellagic acid. , 1996, Indian journal of physiology and pharmacology.

[69]  G. Semenza,et al.  Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 , 1996, Molecular and cellular biology.

[70]  W. Peters,et al.  Quantification of induction of rat oesophageal, gastric and pancreatic glutathione and glutathione S-transferases by dietary anticarcinogens. , 1994, Carcinogenesis.

[71]  Bert Vogelstein,et al.  The GLI gene is a member of the Kruppel family of zinc finger proteins , 1988, Nature.

[72]  Benjamin Purow,et al.  Notch inhibition as a promising new approach to cancer therapy. , 2012, Advances in experimental medicine and biology.

[73]  S. Leach,et al.  Signaling pathways mediating epithelial- mesenchymal crosstalk in pancreatic cancer: Hedgehog, Notch and TGFβ , 2012 .

[74]  S. Shankar,et al.  Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells. , 2011, Frontiers in bioscience.

[75]  M. Lauth,et al.  Hedgehog signaling and pancreatic tumor development. , 2011, Advances in cancer research.

[76]  Gerald C. Chu,et al.  GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. , 2009, Genes & development.

[77]  S. Hingorani,et al.  EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. , 2008, Frontiers in bioscience : a journal and virtual library.

[78]  K. Shetty,et al.  Enhancing health benefits of berries through phenolic antioxidant enrichment: focus on cranberry. , 2005, Asia Pacific journal of clinical nutrition.

[79]  S. Grant,et al.  Apoptosis regulators. , 2003, Reviews in clinical and experimental hematology.

[80]  J. Testa,et al.  Frequent activation of AKT2 kinase in human pancreatic carcinomas , 2002, Journal of cellular biochemistry.

[81]  E. Gold,et al.  Epidemiology of and risk factors for pancreatic cancer. , 1998, Surgical oncology clinics of North America.

[82]  A. Warshaw,et al.  Pancreatic carcinoma. , 1992, The New England journal of medicine.