Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: Protection by diosgenin and l-deprenyl

[1]  Thomas Wisniewski,et al.  A synthetic peptide blocking the apolipoprotein E/β-amyloid binding mitigates β-amyloid toxicity and fibril formation in vitro and reduces β-amyloid plaques in transgenic mice , 2004 .

[2]  R. Portin,et al.  APOE-ε4 predicts dementia but not other psychiatric disorders after traumatic brain injury , 2004, Neurology.

[3]  M. Mattson,et al.  Dysregulation of sphingolipid and sterol metabolism by ApoE4 in HIV dementia , 2004, Neurology.

[4]  B. Hyman,et al.  Apolipoprotein E Receptors Mediate Neurite Outgrowth through Activation of p44/42 Mitogen-activated Protein Kinase in Primary Neurons* , 2004, Journal of Biological Chemistry.

[5]  N. Sacktor,et al.  Neuroprotective therapy for HIV dementia. , 2003, Current HIV research.

[6]  L. Hwang,et al.  Isolation and identification of steroidal saponins in Taiwanese yam cultivar (Dioscorea pseudojaponica Yamamoto). , 2003, Journal of agricultural and food chemistry.

[7]  D. Butterfield,et al.  Intracellular Human Immunodeficiency Virus Tat Expression in Astrocytes Promotes Astrocyte Survival but Induces Potent Neurotoxicity at Distant Sites via Axonal Transport* , 2003, The Journal of Biological Chemistry.

[8]  Rafael A Irizarry,et al.  Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.

[9]  D. Butterfield,et al.  Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants , 2003, Neurology.

[10]  Terence P. Speed,et al.  A comparison of normalization methods for high density oligonucleotide array data based on variance and bias , 2003, Bioinform..

[11]  N. Sacktor.  The epidemiology of human immunodeficiency virus-associated neurological disease in the era of highly active antiretroviral therapy. , 2002, Journal of neurovirology.

[12]  C. Meissner,et al.  Fatal versus non-fatal heroin "overdose": blood morphine concentrations with fatal outcome in comparison to those of intoxicated drivers. , 2002, Forensic science international.

[13]  P. Tienari,et al.  Apolipoprotein E (APOE), PARKIN and catechol-O-methyltransferase (COMT) genes and susceptibility to sporadic Parkinson's disease in Finland , 2002, Neuroscience Letters.

[14]  S. Acharya,et al.  Variation in diosgenin levels among 10 accessions of fenugreek seeds produced in western Canada. , 2002, Journal of agricultural and food chemistry.

[15]  M. Hori,et al.  Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action , 2002, Journal of neuroscience research.

[16]  C. Enzinger,et al.  Apolipoprotein E ε4 is associated with rapid progression of multiple sclerosis , 2001, Neurology.

[17]  W H Wong,et al.  Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[18]  R. Tanzi,et al.  Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands , 2000, Nature Medicine.

[19]  C. Oliveira,et al.  Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasis , 2000, Neuroscience Research.

[20]  E. Rassart,et al.  Binding of an Antibody Mimetic of the Human Low Density Lipoprotein Receptor to Apolipoprotein E Is Governed through Electrostatic Forces , 2000, The Journal of Biological Chemistry.

[21]  K. Marder,et al.  Transdermal selegiline in HIV-associated cognitive impairment: Pilot, placebo-controlled study , 2000, Neurology.

[22]  T. Montine,et al.  4‐Hydroxy‐2(E)‐Nonenal Inhibits CNS Mitochondrial Respiration at Multiple Sites , 1999, Journal of neurochemistry.

[23]  M. Mattson,et al.  HIV-1 Protein Tat Induces Apoptosis of Hippocampal Neurons by a Mechanism Involving Caspase Activation, Calcium Overload, and Oxidative Stress , 1998, Experimental Neurology.

[24]  P. Simmonds,et al.  HIV encephalitis, proviral load and dementia in drug users and homosexuals with AIDS. Effect of neocortical involvement. , 1998, Brain : a journal of neurology.

[25]  Lars Lannfelt,et al.  HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy , 1998, Nature Medicine.

[26]  B. Everitt,et al.  3‐nitropropionic acid‐induced changes in the expression of metabolic and astrocyte mRNAs , 1998, Neuroreport.

[27]  J. Chapman,et al.  APOE in non-Alzheimer amyloidoses , 1998, Neurology.

[28]  N. Sacktor.  A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment , 1998, Neurology.

[29]  M. Collins,et al.  Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification , 1998, Cell Death and Differentiation.

[30]  R J Miller,et al.  Isoform-Specific Effect of Apolipoprotein E on Cell Survival and β-Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures , 1998, The Journal of Neuroscience.

[31]  Luigi Buonaguro,et al.  HIV‐1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix‐associated heparan sulfate proteoglycans through its basic region , 1997, AIDS.

[32]  T. Inagaki,et al.  Dietary diosgenin attenuates subacute intestinal inflammation associated with indomethacin in rats. , 1997, The American journal of physiology.

[33]  P. Lantos,et al.  HIV‐associated brain pathology in the United Kingdom: an epidemiological study , 1997, AIDS.

[34]  K. Liestøl,et al.  HIV dementia and apolipoprotein E , 1997, Acta neurologica Scandinavica.

[35]  A. Nath,et al.  Molecular Determinants for Cellular Uptake of Tat Protein of Human Immunodeficiency Virus Type 1 in Brain Cells , 1996 .

[36]  A. Roses.  Apolipoprotein E in neurology , 1996, Current opinion in neurology.

[37]  D. Magnuson,et al.  Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic , 1996, Journal of virology.

[38]  R. Brownstone,et al.  Human immunodeficiency virus type 1 tat activates non—N‐methyl‐D‐aspartate excitatory amino acid receptors and causes neurotoxicity , 1995, Annals of neurology.

[39]  P. Jones,et al.  Staurosporine inhibits protein kinases activated by Ca2+ and cyclic AMP in addition to inhibiting protein kinase C in rat islets of Langerhans , 1993, Molecular and Cellular Endocrinology.

[40]  C. Achim,et al.  Selective Neuronal Vulnerability in HIV Encephalitis , 1992, Journal of neuropathology and experimental neurology.

[41]  E. Major,et al.  Establishment of a line of human fetal glial cells that supports JC virus multiplication. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[42]  L. Mucke,et al.  Apolipoprotein E , 2007, Journal of Molecular Neuroscience.

[43]  A. Nath,et al.  Pathobiology of Human Immunodeficiency Virus Dementia , 1999, Seminars in neurology.

[44]  D. Vlahov,et al.  Comparison of neuropsychological performance between AIDS-free injecting drug users and homosexual men. , 1997, Neuroepidemiology.

[45]  H. Esterbauer,et al.  Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. , 1991, Free radical biology & medicine.