Conditioned responses elicited by experimentally produced cues for smoking.

Several theories of drug-craving postulate that a signal for drug elicits conditioned responses. However, depending on the theory, a drug cue is said to elicit drug similar, drug compensatory, positive motivational, and negative motivational effects. Since animal data alone cannot tease apart the relative importance of different cue-related processes in the addict, we developed and examined a model of drug cues in the human based on a two-sound, differential conditioning procedure using smoking as the reinforcer. After multiple pairings of a sound with smoking, there was a preference for the smoking cue on a conditioned preference test. The acute effects of smoking (increased heart rate, respiration rate, skin conductance level, skin conductance fluctuations, EEG beta power and trapezius EMG, decreased alpha power) were not affected by the smoking cue, although subjects drew more on their cigarette in the presence of the smoking cue than in the presence of a control cue. Moreover, the cue did not change baseline behaviour except for a possible increase in EEG beta power and an increase in trapezius EMG at about the time when smoking should have occurred. The findings confirm the value of experimental models of drug cues in the human for comparing different cue phenomena in the dependent individual. They indicate that an acquired signal for drug in the human may elicit incentive motivational effects and associated preparatory motor responses in addition to possible conditioned tolerance.

[1]  P. O. Smith,et al.  Reactivity to smoking cues: mediating roles of nicotine dependence and duration of deprivation. , 1996, Addictive behaviors.

[2]  R. Mucha,et al.  Conditioned increases in locomotor activity produced with morphine as an unconditioned stimulus, and the relation of conditioning to acute morphine effect and tolerance. , 1981, Journal of comparative and physiological psychology.

[3]  T. Baker,et al.  Morphine tolerance as habituation. , 1985, Psychological review.

[4]  J. Konorski Integrative activity of the brain , 1967 .

[5]  Troy H. Cooper,et al.  Conditioned learning in alcohol dependence: implications for cue exposure treatment. , 1990, British journal of addiction.

[6]  H. de Wit,et al.  Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. , 1984, Psychological review.

[7]  S. Siegel,et al.  Evidence from rats that morphine tolerance is a learned response. , 1975, Journal of comparative and physiological psychology.

[8]  D. Kooy,et al.  Drug reinforcement studied by the use of place conditioning in rat , 1982, Brain Research.

[9]  K. Götestam,et al.  Conditioned abstinence in alcoholics: a controlled experiment. , 1984, The International journal of the addictions.

[10]  C. Mitchell,et al.  The effect of adrenalectomy on morphine analgesia and tolerance development in rats. , 1972, European journal of pharmacology.

[11]  L. Epstein,et al.  Conditioned tolerance to the heart rate effects of smoking , 1991, Pharmacology Biochemistry and Behavior.

[12]  D J Rohsenow,et al.  Relevance of cue reactivity to understanding alcohol and smoking relapse. , 1988, Journal of abnormal psychology.

[13]  K. Fagerström,et al.  Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. , 1978, Addictive behaviors.

[14]  H. Jasper,et al.  The ten-twenty electrode system of the International Federation. The International Federation of Clinical Neurophysiology. , 1999, Electroencephalography and clinical neurophysiology. Supplement.

[15]  R. Griffiths,et al.  Determinants of puff duration in cigarette smokers: II , 1984, Pharmacology Biochemistry and Behavior.

[16]  K. Nader,et al.  Neurobiological constraints on behavioral models of motivation. , 1997, Annual review of psychology.

[17]  P. Lovibond Tonic and phasic electrodermal measures of human aversive conditioning with long duration stimuli. , 2007, Psychophysiology.

[18]  R. Ehrman,et al.  Effect of smoking cues and cigarette availability on craving and smoking behavior. , 1995, Addictive behaviors.

[19]  J. Turkkan,et al.  Psychophysiological effects of alcohol-related stimuli: I. The role of stimulus intensity. , 1989, Alcoholism, clinical and experimental research.

[20]  L. E. Thomson,et al.  Lack of evidence for context-dependent cocaine-induced sensitization in humans: Preliminary studies , 1994, Pharmacology Biochemistry and Behavior.

[21]  G. Mutz,et al.  Smoking produces a smaller increase in heart rate in the natural smoking environment than in the laboratory. , 1996, Drug and alcohol dependence.

[22]  B. Campbell,et al.  Autonomic and behavioral correlates of appetitive conditioning in rats. , 1997, Behavioral neuroscience.

[23]  K. Berridge,et al.  The neural basis of drug craving: An incentive-sensitization theory of addiction , 1993, Brain Research Reviews.

[24]  A. J. Fridlund,et al.  The Skeletomotor System , 1990 .

[25]  J. Rose,et al.  Nicotine self-administration in animals and humans: similarities and differences , 1997, Psychopharmacology.

[26]  R. Eikelboom,et al.  Conditioning of drug-induced physiological responses. , 1982, Psychological review.