PREPARATION, BIODISTRIBUTION AND STABILITY OF [ZN]BLEOMYCIN COMPLEX AMIR REZA JALILIAN, PEJMAN ROWSHANFARZAD, ALI RAHIMINEJAD- KISOMI, SEDIGHEH MORADKHANI AND FARAHNAZ MOTAMEDI-SEDEH CYCLOTRON/NUCLEAR MEDICINE DEPT., NUCLEAR RESEARCH CENTER FOR AGRICULTURE AND MEDICINE, KARAJ, IRAN

Bleomycin (BLM) has been labeled with various radioisotopes and widely used in therapy and diagnosis. In this study BLM was labeled with [Zn] zinc chloride and its distribution and stability in normal and tumor bearing mice was determined. The complex was obtained at the pH=2 in normal saline at 90 °C in 60 minutes. Radio-TLC showed an overall radiochemical yield of 95-97% (radiochemical purity >97%). The in vitro stability of the complex was determined in mice and human plasma. Preliminary studies were performed to determine distribution of [Zn]BLM in normal and tumor bearing mice on the basis of these results. [Zn]BLM may be used in therapeutic studies due to its suitable physico-chemical properties.

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