Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation

[1]  C. Savage-Dunn,et al.  TGF-beta signaling. , 2005, WormBook : the online review of C. elegans biology.

[2]  Gord Fishell,et al.  Foxg1 Suppresses Early Cortical Cell Fate , 2004, Science.

[3]  R. Maciunas,et al.  Transforming growth factor b as a potential tumor progression factor among hyperdiploid glioblastoma cultures: Evidence for the role of platelet-derived growth factor , 1997, Journal of Neuro-Oncology.

[4]  J. Pietenpol,et al.  The role of transforming growth factor Β in glioma progression , 2004, Journal of Neuro-Oncology.

[5]  J. Massagué.  Integration of Smad and MAPK pathways: a link and a linker revisited. , 2003, Genes & development.

[6]  C. Kenyon,et al.  Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan , 2003, Cell.

[7]  J. Massagué,et al.  Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer , 2003, Nature Reviews Cancer.

[8]  M. Czech.  Insulin's expanding control of forkheads , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[9]  J. Massagué,et al.  Mad Upregulation and Id2 Repression Accompany Transforming Growth Factor (TGF)-β-mediated Epithelial Cell Growth Suppression* , 2003, Journal of Biological Chemistry.

[10]  R. Kucherlapati,et al.  Hierarchical model of gene regulation by transforming growth factor β , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Cori Bargmann,et al.  Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans , 2003, Nature.

[12]  S. Plon,et al.  Loss of Sin3/Rpd3 Histone Deacetylase Restores the DNA Damage Response in Checkpoint-Deficient Strains of Saccharomyces cerevisiae , 2003, Molecular and Cellular Biology.

[13]  J. Massagué,et al.  Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.

[14]  P. Freemont,et al.  Human PLU-1 Has Transcriptional Repression Properties and Interacts with the Developmental Transcription Factors BF-1 and PAX9* , 2003, Journal of Biological Chemistry.

[15]  Michael W. Miller.  Expression of transforming growth factor‐β in developing rat cerebral cortex: Effects of prenatal exposure to ethanol , 2003, The Journal of comparative neurology.

[16]  M. Goumans,et al.  Distribution of phosphorylated Smad2 identifies target tissues of TGF beta ligands in mouse development. , 2003, Gene expression patterns : GEP.

[17]  Carlos L. Arteaga,et al.  Targeting the TGFβ signaling network in human neoplasia , 2003 .

[18]  Gary Ruvkun,et al.  DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism , 2003, Science.

[19]  J. Massagué,et al.  A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. , 2003, Molecular cell.

[20]  M. Götz,et al.  Neuronal or Glial Progeny Regional Differences in Radial Glia Fate , 2003, Neuron.

[21]  Eric C. Griffith,et al.  The Many Forks in FOXO's Road , 2003, Science's STKE.

[22]  M. Eilers,et al.  Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter , 2003, Oncogene.

[23]  J. Massagué,et al.  Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. , 2003, Nature reviews. Cancer.

[24]  J. Massagué,et al.  Mechanisms of TGF-beta signaling from cell membrane to the nucleus. , 2003, Cell.

[25]  J. Rich.  The role of transforming growth factor-beta in primary brain tumors. , 2003, Frontiers in bioscience : a journal and virtual library.

[26]  K. Miyazono,et al.  Two major Smad pathways in TGF‐β superfamily signalling , 2002, Genes to cells : devoted to molecular & cellular mechanisms.

[27]  Hans Clevers,et al.  The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells , 2002, Cell.

[28]  J. Massagué,et al.  Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage , 2002, Nature.

[29]  Alfonso Bellacosa,et al.  Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer , 2002, Nature Medicine.

[30]  Carlos L. Arteaga,et al.  PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization , 2002, Nature Medicine.

[31]  M. Eilers,et al.  Negative regulation of the mammalian UV response by Myc through association with Miz-1. , 2002, Molecular cell.

[32]  Luquan Wang,et al.  Transforming Growth Factor-β2 Is a Transcriptional Target for Akt/Protein Kinase B via Forkhead Transcription Factor* , 2002, The Journal of Biological Chemistry.

[33]  E. Lai,et al.  Brain Factor-1 Controls the Proliferation and Differentiation of Neocortical Progenitor Cells through Independent Mechanisms , 2002, The Journal of Neuroscience.

[34]  L. Parada,et al.  The Molecular and Genetic Basis of Neurological Tumours , 2002, Nature Reviews Cancer.

[35]  J. Massagué,et al.  E2F4/5 and p107 as Smad Cofactors Linking the TGFβ Receptor to c-myc Repression , 2002, Cell.

[36]  C. Sawyers,et al.  The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.

[37]  D. Dowbenko,et al.  The Forkhead Transcription Factor AFX Activates Apoptosis by Induction of the BCL-6 Transcriptional Repressor* , 2002, The Journal of Biological Chemistry.

[38]  Arnold R. Kriegstein,et al.  Dividing Precursor Cells of the Embryonic Cortical Ventricular Zone Have Morphological and Molecular Characteristics of Radial Glia , 2002, The Journal of Neuroscience.

[39]  Ying Li,et al.  AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell Survival* , 2002, The Journal of Biological Chemistry.

[40]  L. Wakefield,et al.  TGF-β signaling: positive and negative effects on tumorigenesis , 2002 .

[41]  J. Slingerland,et al.  PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest , 2002, Nature Medicine.

[42]  Raymond Y. N. Lee,et al.  Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway , 2001, Current Biology.

[43]  D. Accili,et al.  The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. , 2001, The Journal of clinical investigation.

[44]  Allan Balmain,et al.  TGF-β signaling in tumor suppression and cancer progression , 2001, Nature Genetics.

[45]  Nobuaki Tamamaki,et al.  Radial glia is a progenitor of neocortical neurons in the developing cerebral cortex , 2001, Neuroscience Research.

[46]  H. Lodish,et al.  Functional Cloning of the Proto-oncogene Brain Factor-1 (BF-1) As a Smad-binding Antagonist of Transforming Growth Factor-β Signaling* , 2001, The Journal of Biological Chemistry.

[47]  J. Rossant,et al.  FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. , 2001, Genes & development.

[48]  J. Massagué,et al.  TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b , 2001, Nature Cell Biology.

[49]  J. Massagué,et al.  Repression of p15INK4b expression by Myc through association with Miz-1 , 2001, Nature Cell Biology.

[50]  Stefano Stifani,et al.  The Winged-Helix Protein Brain Factor 1 Interacts with Groucho and Hes Proteins To Repress Transcription , 2001, Molecular and Cellular Biology.

[51]  M. Hung,et al.  Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells , 2001, Nature Cell Biology.

[52]  Eric C. Holland,et al.  Gliomagenesis: genetic alterations and mouse models , 2001, Nature Reviews Genetics.

[53]  八木 健,et al.  Alternatively spliced variant of smad2 lacking exon 3 : comparison with wild-type smad2 and smad3 , 2001 .

[54]  A. Balmain,et al.  TGF-beta signaling in tumor suppression and cancer progression. , 2001, Nature genetics.

[55]  Myles Brown,et al.  Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription , 2000, Cell.

[56]  J. Massagué,et al.  TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders , 2000, Cell.

[57]  R. Derynck,et al.  Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF‐β , 2000 .

[58]  J. Lammers,et al.  Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1 , 2000, Current Biology.

[59]  J. Massagué,et al.  BF-1 Interferes with Transforming Growth Factor β Signaling by Associating with Smad Partners , 2000, Molecular and Cellular Biology.

[60]  S. R. Hann,et al.  A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[61]  T. Nakazawa,et al.  Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. , 2000, The Biochemical journal.

[62]  J. Massagué,et al.  Transcriptional control by the TGF‐β/Smad signaling system , 2000 .

[63]  R. Medema,et al.  AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 , 2000, Nature.

[64]  K. Kaestner,et al.  Unified nomenclature for the winged helix/forkhead transcription factors. , 2000, Genes & development.

[65]  Minoru Watanabe,et al.  FAST-1 is a key maternal effector of mesoderm inducers in the early Xenopus embryo. , 1999, Development.

[66]  D. Bigner,et al.  Transforming Growth Factor-β-mediated p15INK4BInduction and Growth Inhibition in Astrocytes Is SMAD3-dependent and a Pathway Prominently Altered in Human Glioma Cell Lines* , 1999, The Journal of Biological Chemistry.

[67]  P. Cohen,et al.  Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence* , 1999, The Journal of Biological Chemistry.

[68]  Geert J. P. L. Kops,et al.  Direct control of the Forkhead transcription factor AFX by protein kinase B , 1999, Nature.

[69]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[70]  D. Bigner,et al.  Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. , 1999, The Journal of biological chemistry.

[71]  R. Derynck,et al.  Transcriptional Activators of TGF-β Responses: Smads , 1998, Cell.

[72]  Yigong Shi,et al.  Crystal Structure of a Smad MH1 Domain Bound to DNA Insights on DNA Binding in TGF-β Signaling , 1998, Cell.

[73]  P. Hoodless,et al.  Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. , 1998, Molecular cell.

[74]  A. Moustakas,et al.  Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[75]  A. Klippel,et al.  Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence* , 1998, The Journal of Biological Chemistry.

[76]  K. Kinzler,et al.  Human Smad3 and Smad4 are sequence-specific transcription activators. , 1998, Molecular cell.

[77]  J. Massagué,et al.  Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. , 1997, Genes & development.

[78]  Minoru Watanabe,et al.  Smad4 and FAST-1 in the assembly of activin-responsive factor , 1997, Nature.

[79]  M. Wigler,et al.  PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer , 1997, Science.

[80]  J. Massagué,et al.  Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways , 1996, Nature.

[81]  Xin Chen,et al.  A transcriptional partner for MAD proteins in TGF-β signalling , 1996, Nature.

[82]  Takao Takahashi,et al.  Interkinetic and Migratory Behavior of a Cohort of Neocortical Neurons Arising in the Early Embryonic Murine Cerebral Wall , 1996, The Journal of Neuroscience.

[83]  S. Xuan,et al.  Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres , 1995, Neuron.

[84]  H. Moses,et al.  Transforming Growth Factor β and Cell Cycle Regulation , 1995 .

[85]  A. Brunet,et al.  Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1). , 1994, The EMBO journal.

[86]  K Y Hui,et al.  A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). , 1994, The Journal of biological chemistry.

[87]  J. Trent,et al.  WAF1, a potential mediator of p53 tumor suppression , 1993, Cell.

[88]  J. Darnell,et al.  Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[89]  S. Burley,et al.  Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5 , 1993, Nature.

[90]  V. Caviness,et al.  Cell cycle parameters and patterns of nuclear movement in the neocortical proliferative zone of the fetal mouse , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[91]  E. Lai,et al.  Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain , 1992, Neuron.

[92]  M. Sporn,et al.  Localization and actions of transforming growth factor-beta s in the embryonic nervous system. , 1991, Development.

[93]  J. Massagué,et al.  Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation , 1990, Cell.