Cancer imaging by optical coherence tomography: preclinical progress and clinical potential

The past decade has seen dramatic technological advances in the field of optical coherence tomography (OCT) imaging. These advances have driven commercialization and clinical adoption in ophthalmology, cardiology and gastrointestinal cancer screening. Recently, an array of OCT-based imaging tools that have been developed for preclinical intravital cancer imaging applications has yielded exciting new capabilities to probe and to monitor cancer progression and response in vivo. Here, we review these results, forecast the future of OCT for preclinical cancer imaging and discuss its exciting potential to translate to the clinic as a tool for monitoring cancer therapy.

[1]  R. Jain,et al.  Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. , 1992, Cancer research.

[2]  K. Oh,et al.  A novel fluorescent derivative of glucose applicable to the assessment of glucose uptake activity of Escherichia coli. , 1996, Biochimica et biophysica acta.

[3]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[4]  C. Tyler-Smith,et al.  Attenuation of green fluorescent protein half-life in mammalian cells. , 1999, Protein engineering.

[5]  G. Elliott,et al.  Green fluorescent protein: A novel viability assay for cryobiological applications. , 2000, Cryobiology.

[6]  In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy , 2001, Nature Medicine.

[7]  T. Milner,et al.  Review of polarization sensitive optical coherence tomography and Stokes vector determination. , 2002, Journal of biomedical optics.

[8]  G. Horneck,et al.  Green Fluorescent Protein (GFP) as a Marker for Cell Viability After UV Irradiation , 2004, Journal of Fluorescence.

[9]  Dai Fukumura,et al.  Peritumor Lymphatics Induced by Vascular Endothelial Growth Factor-C Exhibit Abnormal Function , 2004, Cancer Research.

[10]  Daniel L Marks,et al.  Optical probes and techniques for molecular contrast enhancement in coherence imaging. , 2005, Journal of biomedical optics.

[11]  Nizar Mullani,et al.  Uptake of a Fluorescent Deoxyglucose Analog (2-NBDG) in Tumor Cells , 2005, Molecular Imaging and Biology.

[12]  Youxin Mao,et al.  Feasibility of interstitial Doppler optical coherence tomography for in vivo detection of microvascular changes during photodynamic therapy , 2006, Lasers in surgery and medicine.

[13]  Lei Xu,et al.  Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. , 2006, Cancer research.

[14]  Wolfhard Semmler,et al.  Volumetric high-frequency Doppler ultrasound enables the assessment of early antiangiogenic therapy effects on tumor xenografts in nude mice , 2008, European Radiology.

[15]  Victor X D Yang,et al.  Doppler optical coherence tomography monitoring of microvascular tissue response during photodynamic therapy in an animal model of Barrett's esophagus. , 2007, Gastrointestinal endoscopy.

[16]  Adrian Mariampillai,et al.  Interstitial Doppler optical coherence tomography monitors microvascular changes during photodynamic therapy in a Dunning prostate model under varying treatment conditions. , 2007, Journal of biomedical optics.

[17]  Freddy T. Nguyen,et al.  Optical coherence tomography: a review of clinical development from bench to bedside. , 2007, Journal of biomedical optics.

[18]  G. Johnson,et al.  In vivo small-animal imaging using micro-CT and digital subtraction angiography , 2008, Physics in medicine and biology.

[19]  Adrian Mariampillai,et al.  Interstitial Doppler optical coherence tomography as a local tumor necrosis predictor in photodynamic therapy of prostatic carcinoma: an in vivo study. , 2008, Cancer research.

[20]  Wei Wang,et al.  Simultaneous Molecular and Hypoxia Imaging of Brain Tumors In Vivo Using Spectroscopic Photoacoustic Tomography , 2008, Proceedings of the IEEE.

[21]  Rakesh K. Jain,et al.  Taming vessels to treat cancer. , 2008, Scientific American.

[22]  Lihong V. Wang.  Multiscale photoacoustic microscopy and computed tomography. , 2009, Nature photonics.

[23]  Euiheon Chung,et al.  Secreted Gaussia Luciferase as a Biomarker for Monitoring Tumor Progression and Treatment Response of Systemic Metastases , 2009, PloS one.

[24]  Umar Mahmood,et al.  Evaluation and clinically relevant applications of a fluorescent imaging analog to fluorodeoxyglucose positron emission tomography. , 2009, Journal of biomedical optics.

[25]  Benjamin J Vakoc,et al.  Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging , 2009, Nature Medicine.

[26]  B. Wilson,et al.  Oxygen-independent degradation of HIF-α via bioengineered VHL tumour suppressor complex , 2009, EMBO molecular medicine.

[27]  Timothy J. Muldoon,et al.  Molecular imaging of glucose uptake in oral neoplasia following topical application of fluorescently labeled deoxy‐glucose , 2009, International journal of cancer.

[28]  Dushyant V. Sahani,et al.  Biomarkers of response and resistance to antiangiogenic therapy , 2009, Nature Reviews Clinical Oncology.

[29]  P. Wen,et al.  A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients. , 2009, Cancer research.

[30]  Benjamin J Vakoc,et al.  Fourier-domain optical coherence tomography: recent advances toward clinical utility. , 2009, Current opinion in biotechnology.

[31]  Maciej Wojtkowski,et al.  High-speed optical coherence tomography: basics and applications. , 2010, Applied optics.

[32]  Thomas Benner,et al.  Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[33]  Dai Fukumura,et al.  In vivo imaging of tumors. , 2010, Cold Spring Harbor protocols.

[34]  Joseph A. Izatt,et al.  Longitudinal Optical Imaging of Tumor Metabolism and Hemodynamics , 2010 .

[35]  Lihong V. Wang,et al.  Photoacoustic imaging and characterization of the microvasculature. , 2010, Journal of biomedical optics.

[36]  Amy M. Winkler,et al.  In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model , 2011, Molecular Imaging and Biology.

[37]  Olav Haraldseth,et al.  Intravital microscopy in window chambers: a unique tool to study tumor angiogenesis and delivery of nanoparticles , 2010, Angiogenesis.

[38]  Photini F S Rice,et al.  Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon. , 2010, Journal of biomedical optics.

[39]  Bo Wang,et al.  Advances in Clinical and Biomedical Applications of Photoacoustic Imaging. , 2010, Expert opinion on medical diagnostics.

[40]  Ruikang K Wang,et al.  Three-dimensional optical imaging of microvascular networks within intact lymph node in vivo. , 2010, Journal of biomedical optics.

[41]  Ralph Weissleder,et al.  In vivo imaging in cancer. , 2010, Cold Spring Harbor perspectives in biology.

[42]  J. Drevs,et al.  Biomarkers in Tumor Angiogenesis and Anti-Angiogenic Therapy , 2011, International journal of molecular sciences.

[43]  Brett E Bouma,et al.  Intravascular optical imaging technology for investigating the coronary artery. , 2011, JACC. Cardiovascular imaging.

[44]  Adrian Mariampillai,et al.  Detecting apoptosis using dynamic light scattering with optical coherence tomography. , 2011, Journal of biomedical optics.

[45]  P. Carmeliet,et al.  Molecular mechanisms and clinical applications of angiogenesis , 2011, Nature.

[46]  Hiroshi Ishikawa,et al.  Optical coherence tomography: history, current status, and laboratory work. , 2011, Investigative ophthalmology & visual science.

[47]  Holger Gerhardt,et al.  Basic and Therapeutic Aspects of Angiogenesis , 2011, Cell.

[48]  M. Roizen,et al.  Hallmarks of Cancer: The Next Generation , 2012 .

[49]  Tracy T Batchelor,et al.  Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. , 2012, Cancer research.