The Plains CO2 Reduction Partnership (PCOR) Program, led by the Energy & Environmental Research Center (EERC), regularly updates a numerical model of the Aquistore storage site and conducts simulation work as more injection and monitoring data become available for integration. The significance of the latest work presented in this paper is related to the integration of periodic monitoring data (CO2 flow profile at the injection well and CO2 breakthrough profile at the observation well) into the history-matching workflow using an assisted history-matching workflow to calibrate the simulation model further and provide a better predictive model to help optimize CO2 storage performance.