The macrophage scavenger receptor CD163.

Mature tissue macrophages form a first line of defense to recognize and eliminate potential pathogens; these specialized cells are capable of phagocytosis, degradation of self and foreign materials, establishment of cell-cell interactions, and the production of inflammatory mediators. Mature tissue macrophages express a variety of receptors, including the scavenger receptor cystein-rich (SRCR) superfamily members. CD163 is a member of the SRCR family class B and is expressed on most subpopulations of mature tissue macrophages. The best characterized function of CD163, which is essentially a homeostatic one, is related to the binding of Hemoglobin:Haptoglobin complexes. Furthermore, it has been suggested that CD163 positive macrophages or the soluble form of CD163 plays a role in the resolution of inflammation, as they are found in high numbers in inflamed tissue.

[1]  P. Högger,et al.  Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteine-rich family. , 1999, Biochemical and biophysical research communications.

[2]  P. Wallace,et al.  Endotoxin induces rapid metalloproteinase‐mediated shedding followed by up‐regulation of the monocyte hemoglobin scavenger receptor CD163 , 2002, Journal of leukocyte biology.

[3]  D. Mason,et al.  A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily , 1993, European journal of immunology.

[4]  U. Francke,et al.  Molecular Cloning, Mapping to Human Chromosome 1 q21-q23, and Cell Binding Characteristics of Spα, a New Member of the Scavenger Receptor Cysteine-rich (SRCR) Family of Proteins* , 1997, The Journal of Biological Chemistry.

[5]  Jan Mollenhauer,et al.  DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3–26.1 is deleted in malignant brain tumours , 1997, Nature Genetics.

[6]  B. Haynes,et al.  CD6-ligand interactions: a paradigm for SRCR domain function? , 1997, Immunology today.

[7]  E. Morgunova,et al.  Characterization of Recombinant Soluble Macrophage Scavenger Receptor MARCO* , 2002, The Journal of Biological Chemistry.

[8]  D. Schaer,et al.  Molecular cloning and characterization of the mouse CD163 homologue, a highly glucocorticoid-inducible member of the scavenger receptor cysteine-rich family , 2001, Immunogenetics.

[9]  H. Clevers,et al.  Molecular characterization of the WC1 antigen expressed specifically on bovine CD4-CD8- gamma delta T lymphocytes. , 1992, Journal of immunology.

[10]  S. Moestrup,et al.  Molecular Characterization of the Haptoglobin·Hemoglobin Receptor CD163 , 2004, Journal of Biological Chemistry.

[11]  S. Gordon,et al.  Molecular immunobiology of macrophages: recent progress. , 1995, Current opinion in immunology.

[12]  D. Haskard,et al.  Hemoglobin Scavenger Receptor CD163 Mediates Interleukin-10 Release and Heme Oxygenase-1 Synthesis: Antiinflammatory Monocyte-Macrophage Responses In Vitro, in Resolving Skin Blisters In Vivo, and After Cardiopulmonary Bypass Surgery , 2004, Circulation research.

[13]  A. Poustka,et al.  Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[14]  C. Raman.  CD5, an important regulator of lymphocyte selection and immune tolerance , 2002, Immunologic research.

[15]  B. Davis,et al.  Human monocyte CD163 expression inversely correlates with soluble CD163 plasma levels , 2005, Cytometry. Part B, Clinical cytometry.

[16]  Carl G. Figdor,et al.  Different Faces of the Heme-Heme Oxygenase System in Inflammation , 2003, Pharmacological Reviews.

[17]  S. Moestrup,et al.  Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis. , 2004, Arthritis and rheumatism.

[18]  J. Strominger,et al.  Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1 , 1986, Nature.

[19]  R. Wait,et al.  Elevated levels of soluble CD163 in sera and fluids from rheumatoid arthritis patients and inhibition of the shedding of CD163 by TIMP‐3 , 2002, Clinical and experimental immunology.

[20]  P. Gómez-Puertas,et al.  Expression of porcine CD163 on monocytes/macrophages correlates with permissiveness to African swine fever infection , 2003, Archives of Virology.

[21]  U. Bergmann,et al.  Structure of the Human Macrophage MARCO Receptor and Characterization of Its Bacteria-binding Region* , 1998, The Journal of Biological Chemistry.

[22]  T. K. van den Berg,et al.  CD163‐positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation , 2005, Glia.

[23]  H. Haubeck,et al.  Glucocorticoid-induced appearance of the macrophage subtype RM 3/1 in peripheral blood of man. , 1990, International archives of allergy and applied immunology.

[24]  E. Döpp,et al.  The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in rat recognized by monoclonal antibodies ED1, ED2 and ED3. , 1985, Advances in experimental medicine and biology.

[25]  A. Levy,et al.  Genetically Determined Heterogeneity in Hemoglobin Scavenging and Susceptibility to Diabetic Cardiovascular Disease , 2003, Circulation research.

[26]  N. Rooijen,et al.  The role of perivascular and meningeal macrophages in experimental allergic encephalomyelitis , 2002, Journal of Neuroimmunology.

[27]  P. Högger,et al.  Biochemical Characterization of a Glucocorticoid-Induced Membrane Protein (RM3/1) in Human Monocytes and Its Application as Model System for Ranking Glucocorticoid Potency , 1998, Pharmaceutical Research.

[28]  P. Verschure,et al.  Macrophages and Dendritic Cells during the Early Stages of Antigen‐Induced Arthritis in Rats: Immunohistochemical Analysis of Cryostat Sections of the Whole Knee Joint , 1989, Scandinavian journal of immunology.

[29]  J. Dreier,et al.  Only the soluble form of the scavenger receptor CD163 acts inhibitory on phorbol ester‐activated T‐lymphocytes, whereas membrane‐bound protein has no effect , 2002, FEBS letters.

[30]  Jan G. M. Bolscher,et al.  Identification of the Bacteria-binding Peptide Domain on Salivary Agglutinin (gp-340/DMBT1), a Member of the Scavenger Receptor Cysteine-rich Superfamily* , 2002, The Journal of Biological Chemistry.

[31]  S. Gordon.  Alternative activation of macrophages , 2003, Nature Reviews Immunology.

[32]  J. Roth,et al.  Identification of a novel surface molecule, RM3/1, that contributes to the adhesion of glucocorticoid‐induced human monocytes to endothelial cells , 1996, European journal of immunology.

[33]  T. Langmann,et al.  The Scavenger Receptor CD163: Regulation, Promoter Structure and Genomic Organization , 2000, Pathobiology.

[34]  U. Holmskov,et al.  Cloning of a Novel Scavenger Receptor Cysteine-Rich Type I Transmembrane Molecule (M160) Expressed by Human Macrophages1 , 2000, The Journal of Immunology.

[35]  P. Wallace,et al.  Human monocytes express CD163, which is upregulated by IL-10 and identical to p155. , 2000, Cytokine.

[36]  C. Buechler,et al.  Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C , 2001, European journal of immunology.

[37]  M. Krieger,et al.  The other side of scavenger receptors: pattern recognition for host defense , 1997, Current opinion in lipidology.

[38]  S. Hauptmann,et al.  Differential adherence of the human monocyte subsets 27E10 and RM3/1 to cytokine- or glucocorticoid-treated endothelial cells. , 1994, Pathobiology : journal of immunopathology, molecular and cellular biology.

[39]  P. H. Petersen,et al.  Soluble CD163: a marker molecule for monocyte/macrophage activity in disease , 2002, Scandinavian journal of clinical and laboratory investigation. Supplementum.

[40]  S. Moestrup,et al.  CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma. , 2002, The international journal of biochemistry & cell biology.

[41]  P. Guyre,et al.  Cross‐linking of FcγR triggers shedding of the hemoglobin‐haptoglobin scavenger receptor CD163 , 2004, Journal of leukocyte biology.

[42]  P. Högger,et al.  Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family (CD163). , 1998, Journal of immunology.

[43]  Q. Al-Awqati,et al.  Hensin, a new collecting duct protein involved in the in vitro plasticity of intercalated cell polarity. , 1996, The Journal of clinical investigation.

[44]  J. Graversen,et al.  Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes , 2001, Redox report : communications in free radical research.

[45]  W. Mayer,et al.  A cDNA clone from the sea lamprey Petromyzon marinus coding for a scavenger receptor Cys-rich (SRCR) domain protein. , 1995, Gene.

[46]  Xiao-Jiang Li,et al.  Molecular Cloning of Ebnerin, a von Ebners Gland Protein Associated with Taste Buds (*) , 1995, The Journal of Biological Chemistry.

[47]  T. Langmann,et al.  Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro‐ and antiinflammatory stimuli , 2000, Journal of leukocyte biology.

[48]  S. Moestrup,et al.  Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma. , 2002, Blood.

[49]  P. Guyre,et al.  Increase in plasma and surface CD163 levels in patients undergoing coronary artery bypass graft surgery. , 2003, Atherosclerosis.

[50]  R. Stahlmann,et al.  Influence of dexamethasone on the RM 3/1-positive macrophages in the peripheral blood and tissues of a New World monkey (the marmoset Callithrix jacchus). , 1992, International archives of allergy and immunology.

[51]  P. Högger,et al.  Soluble CD163 inhibits phorbol ester-induced lymphocyte proliferation. , 2001, Biochemical and biophysical research communications.

[52]  M. Krieger,et al.  The SRCR superfamily: a family reminiscent of the Ig superfamily. , 1994, Trends in biochemical sciences.

[53]  S. Moestrup,et al.  Identification of the haemoglobin scavenger receptor , 2001, Nature.

[54]  R. Timpl,et al.  Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily , 1999, Nature Structural Biology.

[55]  R. Beelen,et al.  Regulation of CD163 on human macrophages: cross‐linking of CD163 induces signaling and activation , 1999, Journal of leukocyte biology.

[56]  M. Bjerknes,et al.  CRP‐ductin: A gene expressed in intestinal crypts and in pancreatic and hepatic ducts , 1996, The Anatomical record.

[57]  S. Moestrup,et al.  Plasma level of the macrophage‐derived soluble CD163 is increased and positively correlates with severity in Gaucher's disease , 2004, European journal of haematology.

[58]  S. Gordon,et al.  Homeostasis: A scavenger receptor for haemoglobin , 2001, Current Biology.