Cue-provoked craving and nicotine replacement therapy in smoking cessation.

Cue exposure paradigms have been used to examine reactivity to smoking cues. However, it is not known whether cue-provoked craving is associated with smoking cessation outcomes or whether cue reactivity can be attenuated by nicotine replacement therapy (NRT) in clinical samples. Cue-provoked craving ratings and reaction time responses were measured on the 1st day of abstinence among 158 smokers who had been randomized to high-dose nicotine (35 mg) or placebo patch. The nicotine patch reduced overall levels of craving but did not attenuate cue-provoked craving increases or reaction time responses. Cue-provoked craving predicted relapse among participants on the nicotine patch but not among those on placebo. In summary, NRT users could benefit from treatment that attenuates cue-provoked craving.

[1]  D. Schroeder,et al.  High-dose nicotine patch therapy. Percentage of replacement and smoking cessation. , 1995, JAMA.

[2]  D J Rohsenow,et al.  Does Urge To Drink Predict Relapse After Treatment? , 1999, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.

[3]  S. Shiffman,et al.  Efficacy of acute administration of nicotine gum in relief of cue-provoked cigarette craving , 2003, Psychopharmacology.

[4]  B. Carter,et al.  Meta-analysis of cue-reactivity in addiction research. , 1999, Addiction.

[5]  J. Fiez,et al.  Prefrontal responses to drug cues: a neurocognitive analysis , 2004, Nature Neuroscience.

[6]  R. Ehrman,et al.  Effect of smoking cues and cigarette availability on craving and smoking behavior. , 1995, Addictive behaviors.

[7]  S Shiffman,et al.  A day at a time: predicting smoking lapse from daily urge. , 1997, Journal of abnormal psychology.

[8]  Charles A. Warren,et al.  Event-related brain potentials as indicators of smoking cue-reactivity , 1999, Clinical Neurophysiology.

[9]  P. O. Smith,et al.  Reactivity to smoking cues: mediating roles of nicotine dependence and duration of deprivation. , 1996, Addictive behaviors.

[10]  P M Monti,et al.  Reactivity to high risk situations and smoking cessation outcome. , 1989, Journal of substance abuse.

[11]  Reactivity to instructed smoking availability and environmental cues: Evidence with urge and reaction time. , 1998 .

[12]  L. Kozlowski,et al.  The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. , 1991, British journal of addiction.

[13]  D J Rohsenow,et al.  Relevance of cue reactivity to understanding alcohol and smoking relapse. , 1988, Journal of abnormal psychology.

[14]  A. Garvey,et al.  Urges to smoke during the first month of abstinence: relationship to relapse and predictors , 1995, Psychopharmacology.

[15]  Dennis M. Donovan,et al.  Relapse prevention: Maintenance strategies in the treatment of addictive behaviors, 2nd ed. , 2005 .

[16]  S. Fortmann,et al.  Craving is associated with smoking relapse: findings from three prospective studies. , 1997, Experimental and clinical psychopharmacology.

[17]  Effects of cue exposure and deprivation on cognitive resources in smokers. , 1994 .

[18]  R. Perera,et al.  Nicotine replacement therapy for smoking cessation. , 2012, The Cochrane database of systematic reviews.

[19]  S. Tiffany,et al.  Applying extinction research and theory to cue-exposure addiction treatments. , 2002, Addiction.

[20]  S. Shiffman,et al.  Attentional bias predicts outcome in smoking cessation. , 2003, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[21]  S Shiffman,et al.  A multi-dimensional analysis of cue-elicited craving in heavy smokers and tobacco chippers. , 2001, Addiction.

[22]  Saul Shiffman,et al.  Relapse following smoking cessation: a situational analysis. , 1982, Journal of consulting and clinical psychology.

[23]  S. Shiffman,et al.  A pharmacokinetic crossover study to compare the absorption characteristics of three transdermal nicotine patches , 2000, Pharmacology Biochemistry and Behavior.

[24]  S. Shiffman,et al.  The nicotine dependence syndrome scale: a multidimensional measure of nicotine dependence. , 2004, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[25]  S. Heishman,et al.  Tobacco craving: intensity-related effects of imagery scripts in drug abusers. , 2000, Experimental and clinical psychopharmacology.

[26]  L. Cox,et al.  Effects of transdermal nicotine patches on abstinence-induced and cue-elicited craving in cigarette smokers. , 2000, Journal of consulting and clinical psychology.

[27]  S. Shiffman,et al.  The measurement of drug craving. , 2000, Addiction.

[28]  D. Abrams,et al.  Cue exposure treatment for smoking relapse prevention: a controlled clinical trial. , 1999, Addiction.

[29]  Raja Parasuraman,et al.  Varieties of attention , 1984 .

[30]  M. Aickin,et al.  Effects of nicotine dose and administration method on withdrawal symptoms and side effects during short-term smoking abstinence. , 1997, Experimental and clinical psychopharmacology.

[31]  D. Abrams,et al.  Reactivity to smoking cues and relapse: two studies of discriminant validity. , 1988, Behaviour research and therapy.

[32]  K. Perkins,et al.  Sex differences in nicotine effects and self-administration: review of human and animal evidence. , 1999, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[33]  D. Abrams,et al.  Individual differences in cue reactivity among smokers trying to quit: effects of gender and cue type. , 1998, Addictive behaviors.

[34]  S. Shiffman,et al.  Recent advances in the pharmacotherapy of smoking. , 1999, JAMA.

[35]  D. Abrams,et al.  Responses to smoking-related stimuli and early relapse to smoking. , 1989, Addictive behaviors.

[36]  S. Shiffman,et al.  First lapses to smoking: within-subjects analysis of real-time reports. , 1996, Journal of consulting and clinical psychology.

[37]  G. Marlatt,et al.  Addictive behaviour: Cue exposure theory and practice. , 1995 .

[38]  W. Velicer,et al.  Biochemical verification of tobacco use and cessation. , 2002, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[39]  M. Sayette,et al.  A review of the effects of perceived drug use opportunity of self-reported urge. , 2001, Experimental and clinical psychopharmacology.