Lactoferrin supplementation to dairy calves.

Twenty-one Holstein calves (12 bulls, 9 heifers) were used to evaluate the effects of supplemental lactoferrin (0, 1, and 10 g/d) added to colostrum, milk, and milk replacer in a 56-d study. Calves fed lactoferrin (LF) weighed more during wk 2, 3, 4, 5, and 6 than control calves. Calves fed LF had increased preweaning daily weight gains and heart girth gains compared with calves not fed lactoferrin. Calves fed 1 g/d LF had a greater preweaning average daily gain than calves fed 10 g/d of lactoferrin. Hematocrit and serum Fe were unaffected by treatments. Calves were weaned when they had consumed 0.7 kg of calf starter grain for 2 consecutive d and were at least 28 d of age. All calves were weaned by 35 d of age, regardless of starter intake. Calves fed LF consumed more calf starter grain during the preweaning period and met weaning criteria at a younger age. This study indicates that supplementing calf diets with LF is advantageous to calf performance.

[1]  H. Hayasawa,et al.  Bovine lactoferrin stimulates the phagocytic activity of human neutrophils: identification of its active domain. , 1998, Cellular immunology.

[2]  Shin,et al.  Antibacterial activity of bovine lactoferrin and its peptides against enterohaemorrhagic Escherichia coli O157:H7 , 1998, Letters in applied microbiology.

[3]  S. Kume,et al.  Effect of supplemental lactoferrin with ferrous iron on iron status of newborn calves. , 1996, Journal of dairy science.

[4]  S. Kume,et al.  Effect of twinning and supplemental iron-saturated lactoferrin on iron status of newborn calves. , 1994, Journal of dairy science.

[5]  P. Furmanski,et al.  Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice. , 1994, Cancer research.

[6]  J. Drackley,et al.  Whole milk and oral rehydration solution for calves with diarrhea of spontaneous origin. , 1994, Journal of dairy science.

[7]  D. Dionysius,et al.  Forms of lactoferrin: their antibacterial effect on enterotoxigenic Escherichia coli. , 1993, Journal of dairy science.

[8]  M. Lewis,et al.  Influence of apo- and iron-saturated lactoferrin and transferrin, immunoglobulin G and serum albumin on proliferation of bovine peripheral blood mononuclear cells , 1992 .

[9]  S. Oliver,et al.  Proliferation of the MAC-T bovine mammary epithelial cell line in the presence of mammary secretion whey proteins. , 1992, Cell biology international reports.

[10]  K. Yamauchi,et al.  Potent antibacterial peptides generated by pepsin digestion of bovine lactoferrin. , 1991, Journal of dairy science.

[11]  R. Warner.  Nutritional factors affecting the development of a functional ruminant: a historical perspective , 1991 .

[12]  P. Delahaut,et al.  Treatment of induced enterotoxigenic colibacillosis (scours) in calves by the lactoperoxidase system and lactoferrin. , 1990, Annales de recherches veterinaires. Annals of veterinary research.

[13]  S. Fairweather-Tait,et al.  Lactoferrin and Iron Absorption in Newborn Infants , 1987, Pediatric Research.

[14]  M. Murphy,et al.  Abomasal pH, nutrient digestibility, and growth of Holstein bull calves fed acidified milk replacer. , 1987, Journal of dairy science.

[15]  B. Lönnerdal.  Biochemistry and physiological function of human milk proteins. , 1985, The American journal of clinical nutrition.

[16]  R. Finkelstein,et al.  Antimicrobial effects of human milk: Inhibitory activity on enteric pathogens , 1985 .

[17]  Smith Kl,et al.  Lactoferrin: a component of nonspecific defense of the involuting bovine mammary gland. , 1981 .

[18]  W. Horwitz.  Official Methods of Analysis , 1980 .

[19]  J. Mcghee,et al.  A bactericidal effect for human lactoferrin. , 1977, Science.

[20]  J. Brock,et al.  Inhibition of Escherichia coli by bovine colostrum and post-colostral milk. II. The bacteriostatic effect of lactoferrin on a serum susceptible and serum resistant strain of E. coli. , 1975, Immunology.

[21]  A. P. Potapov,et al.  The dependence of fluorescence quantum yield of the tRNA—acriflavine complexes on the conformational changes in tRNA , 1972, FEBS letters.

[22]  H. Goering.  Forage Fiber Analyses , 1970 .