Algorithms to qualify respiratory data collected during the transport of trauma patients

We developed a quality indexing system to numerically qualify respiratory data collected by vital-sign monitors in order to support reliable post-hoc mining of respiratory data. Each monitor-provided (reference) respiratory rate (RR(R)) is evaluated, second-by-second, to quantify the reliability of the rate with a quality index (QI(R)). The quality index is calculated from: (1) a breath identification algorithm that identifies breaths of 'typical' sizes and recalculates the respiratory rate (RR(C)); (2) an evaluation of the respiratory waveform quality (QI(W)) by assessing waveform ambiguities as they impact the calculation of respiratory rates and (3) decision rules that assign a QI(R) based on RR(R), RR(C) and QI(W). RR(C), QI(W) and QI(R) were compared to rates and quality indices independently determined by human experts, with the human measures used as the 'gold standard', for 163 randomly chosen 15 s respiratory waveform samples from our database. The RR(C) more closely matches the rates determined by human evaluation of the waveforms than does the RR(R) (difference of 3.2 +/- 4.6 breaths min(-1) versus 14.3 +/- 19.3 breaths min(-1), mean +/- STD, p < 0.05). Higher QI(W) is found to be associated with smaller differences between calculated and human-evaluated rates (average differences of 1.7 and 8.1 breaths min(-1) for the best and worst QI(W), respectively). Establishment of QI(W) and QI(R), which ranges from 0 for the worst-quality data to 3 for the best, provides a succinct quantitative measure that allows for automatic and systematic selection of respiratory waveforms and rates based on their data quality.

[1]  J P Gassler,et al.  Heart failure and sleep-related breathing disorders. , 2000, Cardiology in review.

[2]  Thomas Voit,et al.  Respiratory function assessment and intervention in neuromuscular disorders , 2005, Current opinion in neurology.

[3]  F. Wilhelm,et al.  Respiratory sinus arrhythmia, cardiac vagal control, and daily activity. , 2004, American journal of physiology. Heart and circulatory physiology.

[4]  J. Cacioppo,et al.  Respiratory sinus arrhythmia: autonomic origins, physiological mechanisms, and psychophysiological implications. , 1993, Psychophysiology.

[5]  Shieh Ching Yang,et al.  Effects of inspiratory flow waveforms on lung mechanics, gas exchange, and respiratory metabolism in COPD patients during mechanical ventilation. , 2002, Chest.

[6]  Louis-Gilles Durand,et al.  Phonospirometry for noninvasive measurement of ventilation: methodology and preliminary results. , 2002, Journal of applied physiology.

[7]  A. V. van Vugt,et al.  Comparison of current injury scales for survival chance estimation: an evaluation comparing the predictive performance of the ISS, NISS, and AP scores in a Dutch local trauma registration. , 2005, The Journal of trauma.

[8]  M A Sackner,et al.  Measurement of breath amplitudes: Comparison of three noninvasive respiratory monitors to integrated pneumotachograph , 1993, Pediatric pulmonology.

[9]  S. Javaheri,et al.  Heart failure and sleep apnea: emphasis on practical therapeutic options. , 2003, Clinics in chest medicine.

[10]  P Burdett-Smith,et al.  A patient who changed my practice: Always check the respiratory rate , 1997 .

[11]  R H Smallwood,et al.  Movement artefact rejection in impedance pneumography using six strategically placed electrodes. , 2000, Physiological measurement.

[12]  S. Kromhout-Schiro,et al.  Glasgow Coma Scale score, mortality, and functional outcome in head-injured patients. , 2004, The Journal of trauma.

[13]  Alpo Värri,et al.  Automatic detection of spiking events in EMFi sheet during sleep. , 2006, Medical engineering & physics.

[14]  J. Koehler,et al.  Prehospital Index: a scoring system for field triage of trauma victims. , 1985, Annals of emergency medicine.

[15]  I V Krylova,et al.  [Potentials of hyperbaric oxygenation in correcting central respiratory disorders in ischemic stroke]. , 1979, Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko.

[16]  Robert L. Davis,et al.  Use of a respiratory clinical score among different providers , 2004, Pediatric pulmonology.

[17]  Michel Galinier,et al.  [Sleep apnea syndromes and cardiovascular disease]. , 2005, Bulletin de l'Academie nationale de medecine.

[18]  T A Gennarelli,et al.  A revision of the Trauma Score. , 1989, The Journal of trauma.

[19]  Ruth Kleinpell-Nowell Working With Respiratory Waveforms: How to Use Bedside Graphics , 2003 .

[20]  R. Kallet,et al.  Effects of tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome* , 2006, Critical care medicine.

[21]  Michel Galinier,et al.  Syndromes d’apnées du sommeil et pathologie cardiovasculaire , 2005 .

[22]  Conor Heneghan,et al.  Automated processing of the single-lead electrocardiogram for the detection of obstructive sleep apnoea , 2003, IEEE Transactions on Biomedical Engineering.

[23]  Umberto Lucangelo,et al.  Respiratory mechanics derived from signals in the ventilator circuit. , 2005, Respiratory care.

[24]  D. Dorfman,et al.  Maximum-likelihood estimation of parameters of signal-detection theory and determination of confidence intervals—Rating-method data , 1969 .

[25]  F. Yasuma,et al.  Respiratory sinus arrhythmia: why does the heartbeat synchronize with respiratory rhythm? , 2004, Chest.

[26]  Xin Zhu,et al.  Unconstrained detection of respiration rhythm and pulse rate with one under-pillow sensor during sleep , 2005, Medical and Biological Engineering and Computing.

[27]  W. J. Tompkins,et al.  Comparison of impedance and inductance ventilation sensors on adults during breathing, motion, and simulated airway obstruction , 1997, IEEE Transactions on Biomedical Engineering.

[28]  C. Hunt,et al.  Comparison of respiratory inductive plethysmography and thoracic impedance for apnea monitoring. , 1987, The Journal of pediatrics.

[29]  B. Hök,et al.  Critical review of non-invasive respiratory monitoring in medical care , 2003, Medical and Biological Engineering and Computing.

[30]  R. Lorenz,et al.  The definition of “Cheyne-Stokes rhythms” , 1978, Acta Neurochirurgica.

[31]  Liborio Parrino,et al.  Obstructive sleep-disordered breathing with a dominant cyclic alternating pattern--a recognizable polysomnographic variant with practical clinical implications. , 2004, Sleep.

[32]  G Lister,et al.  Comparison of apnea identified by respiratory inductance plethysmography with that detected by end-tidal CO(2) or thermistor. The CHIME Study Group. , 2000, American journal of respiratory and critical care medicine.

[33]  J. Cacioppo,et al.  Impedance pneumography: noise as signal in impedance cardiography. , 1999, Psychophysiology.