Mechano-neuromodulation of autonomic pelvic nerve for underactive bladder: A triboelectric neurostimulator integrated with flexible neural clip interface

Abstract Mechano-neuromodulation of autonomic pelvic nerves was demonstrated for the first time using a triboelectric neurostimulator integrated with flexible neural clip interface. The detailed stimulation parameters such as current, pulse width, and charges generated by the proposed TENG were investigated for the stimulation of autonomic pelvic nerve. In in vivo experiments, different beats per minute (BPM) were delivered to the nerves to investigate the effect of stimulation frequency on mechano-neurostimulation while monitoring changes in bladder pressure and the occurrence of micturition. Furthermore, different numbers of pulses were applied to stimulate the pelvic nerve. The bladder contractions with micturition were observed when applying more than 50 BPM as well as one pulse. Comparison of stimulation was performed using a commercial stimulator with the similar long-pulse widths as generated by TENGs. In addition, chronic implantation of flexible clip interface was demonstrated with functionality test of the interface. The results demonstrate that this technology may potentially be used for self-powered mechano-neuromodulation for bladder function in the future.

[1]  P. Dorsher,et al.  Neurogenic Bladder , 2012, Advances in urology.

[2]  Brian Litt,et al.  Drug discovery: A jump-start for electroceuticals , 2013, Nature.

[3]  P. Abrams,et al.  Signs and Symptoms of Detrusor Underactivity: An Analysis of Clinical Presentation and Urodynamic Tests From a Large Group of Patients Undergoing Pressure Flow Studies. , 2016, European urology.

[4]  W. Cai,et al.  Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators , 2018, ACS nano.

[5]  Igor Adameyko,et al.  Neural circuitry gets rewired , 2016, Science.

[6]  Giorgia Pastorin,et al.  Toward Self‐Powered Wearable Adhesive Skin Patch with Bendable Microneedle Array for Transdermal Drug Delivery , 2016, Advanced science.

[7]  S.F. Cogan,et al.  Electrodeposited iridium oxide for neural stimulation and recording electrodes , 2001, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[8]  Shih-Cheng Yen,et al.  Progress of Flexible Electronics in Neural Interfacing – A Self‐Adaptive Non‐Invasive Neural Ribbon Electrode for Small Nerves Recording , 2016, Advanced materials.

[9]  Sanghoon Lee,et al.  Toward advanced neural interfaces for the peripheral nervous system (PNS) and their future applications , 2018, Current Opinion in Biomedical Engineering.

[10]  E. Purcell,et al.  Micro-Reflector Integrated Multichannel μLED Optogenetic Neurostimulator With Enhanced Intensity , 2018, Front. Mech. Eng..

[11]  Roger K. W. Hui,et al.  APL\? , 1990, APL '90.

[12]  Tsuyoshi Murata,et al.  {m , 1934, ACML.

[13]  Chengkuo Lee,et al.  Toward Bioelectronic Medicine—Neuromodulation of Small Peripheral Nerves Using Flexible Neural Clip , 2017, Advanced science.

[14]  Hao Wang,et al.  A Highly Selective 3D Spiked Ultraflexible Neural (SUN) Interface for Decoding Peripheral Nerve Sensory Information , 2018, Advanced healthcare materials.

[15]  Zhou Li,et al.  Recent Progress on Piezoelectric and Triboelectric Energy Harvesters in Biomedical Systems , 2017, Advanced science.

[16]  Lei Jin,et al.  Direct Powering a Real Cardiac Pacemaker by Natural Energy of a Heartbeat. , 2019, ACS nano.

[17]  Nitish V Thakor,et al.  Self-Powered Direct Muscle Stimulation Using a Triboelectric Nanogenerator (TENG) Integrated with a Flexible Multiple-Channel Intramuscular Electrode. , 2019, ACS nano.

[18]  Weiyang Yang,et al.  Single-channel opto-neurostimulators: a review , 2019, Journal of Micromechanics and Microengineering.

[19]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[20]  Shih-Cheng Yen,et al.  Closed-loop stimulation of the pelvic nerve for optimal micturition , 2018, Journal of neural engineering.

[21]  Yinghuai Qiang,et al.  Enhancing proliferation and migration of fibroblast cells by electric stimulation based on triboelectric nanogenerator , 2019, Nano Energy.

[22]  Warren M Grill,et al.  Principles of electrical stimulation of neural tissue. , 2013, Handbook of clinical neurology.

[23]  Byung Jin Cho,et al.  Hybrid composite of screen-printed inorganic thermoelectric film and organic conducting polymer for flexible thermoelectric power generator , 2014 .

[24]  S. Yen,et al.  Design and Anchorage Dependence of Shape Memory Alloy Actuators on Enhanced Voiding of a Bladder , 2018 .

[25]  Shih-Cheng Yen,et al.  Toward Self-Control Systems for Neurogenic Underactive Bladder: A Triboelectric Nanogenerator Sensor Integrated with a Bistable Micro-Actuator. , 2018, ACS nano.

[26]  Front , 2020, 2020 Fourth World Conference on Smart Trends in Systems, Security and Sustainability (WorldS4).

[27]  Annalisa Bonfiglio,et al.  Fully Textile, PEDOT:PSS Based Electrodes for Wearable ECG Monitoring Systems , 2016, IEEE Transactions on Biomedical Engineering.

[28]  Huicong Liu,et al.  A comprehensive review on piezoelectric energy harvesting technology: Materials, mechanisms, and applications , 2018, Applied Physics Reviews.

[29]  Weiqi Wang,et al.  High-performance triboelectric nanogenerator with enhanced energy density based on single-step fluorocarbon plasma treatment , 2014 .

[30]  Xuewen Wang,et al.  Silk‐Molded Flexible, Ultrasensitive, and Highly Stable Electronic Skin for Monitoring Human Physiological Signals , 2014, Advanced materials.

[31]  Boris Murmann,et al.  Highly stretchable polymer semiconductor films through the nanoconfinement effect , 2017, Science.

[32]  K. Yun,et al.  Energy harvester using contact-electrification of magnetic fluid droplets under oscillating magnetic field , 2015 .

[33]  Nitish V. Thakor,et al.  Novel Neurostimulation of Autonomic Pelvic Nerves Overcomes Bladder-Sphincter Dyssynergia , 2018, Front. Neurosci..

[34]  Bowen Ji,et al.  A novel assembly method for 3-dimensional microelectrode array with micro-drive , 2018, Sensors and Actuators B: Chemical.

[35]  U. Schnakenberg,et al.  Sputtered Iridium Oxide Films as Charge Injection Material for Functional Electrostimulation , 2004 .

[36]  Sam Emaminejad,et al.  Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis , 2016, Nature.

[37]  S. Yen,et al.  A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators , 2017, Advanced science.

[38]  Qiongfeng Shi,et al.  More than energy harvesting – Combining triboelectric nanogenerator and flexible electronics technology for enabling novel micro-/nano-systems , 2019, Nano Energy.

[39]  Puchuan Tan,et al.  Nanogenerator for Biomedical Applications , 2018, Advanced healthcare materials.

[40]  장윤희,et al.  Y. , 2003, Industrial and Labor Relations Terms.

[41]  Jun Li,et al.  Effective weight control via an implanted self-powered vagus nerve stimulation device , 2018, Nature Communications.

[42]  Qiongfeng Shi,et al.  Development of battery-free neural interface and modulated control of tibialis anterior muscle via common peroneal nerve based on triboelectric nanogenerators (TENGs) , 2017 .

[43]  Xiaoyang Kang,et al.  Flexible Optoelectric Neural Interface Integrated Wire-Bonding $\mu$ LEDs and Microelectrocorticography for Optogenetics , 2017, IEEE Transactions on Electron Devices.

[44]  Changfeng Tai,et al.  Impact of Bioelectronic Medicine on the Neural Regulation of Pelvic Visceral Function , 2015, Bioelectronic medicine.

[45]  Nitish V. Thakor,et al.  Mapping of Small Nerve Trunks and Branches Using Adaptive Flexible Electrodes , 2016, Advanced science.

[46]  Xiaojing Mu,et al.  Triboelectric liquid volume sensor for self-powered lab-on-chip applications , 2016 .

[47]  이화영.  X , 1960, Chinese Plants Names Index 2000-2009.

[48]  Qiongfeng Shi,et al.  Battery-free neuromodulator for peripheral nerve direct stimulation , 2018, Nano Energy.

[49]  Andrew G. Glen,et al.  APPL , 2001 .