Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load.

[1]  N. Larsson,et al.  Mammalian Mitochondria and Aging: An Update. , 2017, Cell metabolism.

[2]  F. Gao,et al.  Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis , 2016, Nature Structural &Molecular Biology.

[3]  J. Manfredi,et al.  Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging , 2016, Oncotarget.

[4]  Karl R. Clauser,et al.  MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins , 2015, Nucleic Acids Res..

[5]  S. Jakobs,et al.  Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid , 2015, Proceedings of the National Academy of Sciences.

[6]  Patrick F. Chinnery,et al.  The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease , 2015, Nature Reviews Genetics.

[7]  J. Smeitink,et al.  MtDNA mutagenesis impairs elimination of mitochondria during erythroid maturation leading to enhanced erythrocyte destruction , 2015, Nature Communications.

[8]  T. Franz,et al.  Up to date sample preparation of proteins for mass spectrometric analysis , 2014, Archives of physiology and biochemistry.

[9]  Marco Y. Hein,et al.  Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ * , 2014, Molecular & Cellular Proteomics.

[10]  E. Schon,et al.  NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease , 2014, Cell metabolism.

[11]  J. Auwerx,et al.  Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3 , 2014, EMBO molecular medicine.

[12]  F. Fakhfakh,et al.  Identification of a novel m.9588G > A missense mutation in the mitochondrial COIII gene in asthenozoospermic Tunisian infertile men , 2014, Journal of Assisted Reproduction and Genetics.

[13]  Eleni G. Christodoulou,et al.  Meiotic Cohesin SMC1β Provides Prophase I Centromeric Cohesion and Is Required for Multiple Synapsis-Associated Functions , 2013, PLoS genetics.

[14]  B. Hoffer,et al.  Germline mtDNA mutations aggravate ageing and can impair brain development , 2013, Nature.

[15]  Richard D Emes,et al.  Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia. , 2013, American journal of human genetics.

[16]  B. Durand,et al.  Drosophila chibby is required for basal body formation and ciliogenesis but not for Wg signaling , 2012, The Journal of cell biology.

[17]  H. Erdjument-Bromage,et al.  LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs , 2012, The EMBO journal.

[18]  T. Prolla,et al.  Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. , 2012, Cell metabolism.

[19]  J. Ross,et al.  Visualization of mitochondrial respiratory function using cytochrome c oxidase/succinate dehydrogenase (COX/SDH) double-labeling histochemistry. , 2011, Journal of visualized experiments : JoVE.

[20]  S. Jakobs,et al.  Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA , 2011, Proceedings of the National Academy of Sciences.

[21]  E. Schon,et al.  In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis , 2011, Cell metabolism.

[22]  M. Mann,et al.  Andromeda: a peptide search engine integrated into the MaxQuant environment. , 2011, Journal of proteome research.

[23]  N. Larsson Somatic mitochondrial DNA mutations in mammalian aging. , 2010, Annual review of biochemistry.

[24]  A. Amaral,et al.  Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells. , 2009, Human reproduction update.

[25]  Jan Nedergaard,et al.  Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice. , 2009, Cell metabolism.

[26]  R. Benavente,et al.  Mutation of the Mouse Syce1 Gene Disrupts Synapsis and Suggests a Link between Synaptonemal Complex Structural Components and DNA Repair , 2009, PLoS genetics.

[27]  M. Mann,et al.  MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification , 2008, Nature Biotechnology.

[28]  H. Okada,et al.  Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis , 2008, The Journal of cell biology.

[29]  M. Griswold,et al.  Loss of polyadenylation protein τCstF-64 causes spermatogenic defects and male infertility , 2007, Proceedings of the National Academy of Sciences.

[30]  Stephen S. Taylor,et al.  Bub1 maintains centromeric cohesion by activation of the spindle checkpoint. , 2007, Developmental cell.

[31]  J. Boivin,et al.  International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. , 2007, Human reproduction.

[32]  H. Yonekawa,et al.  Mitochondria-related male infertility , 2006, Proceedings of the National Academy of Sciences.

[33]  T. D. Pugh,et al.  Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging , 2005, Science.

[34]  Howard T. Jacobs,et al.  Premature ageing in mice expressing defective mitochondrial DNA polymerase , 2004, Nature.

[35]  P. Rustin,et al.  Mitochondrial transcription factor A regulates mtDNA copy number in mammals. , 2004, Human molecular genetics.

[36]  E. Dufour,et al.  A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[37]  T. Kornberg,et al.  Human BOULE gene rescues meiotic defects in infertile flies. , 2003, Human molecular genetics.

[38]  D. Turnbull,et al.  Can mitochondrial DNA mutations cause sperm dysfunction? , 2002, Molecular human reproduction.

[39]  G. Barsh,et al.  Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice , 1998, Nature Genetics.

[40]  Yau-Huei Wei,et al.  Mitochondrial deoxyribonucleic acid 4977-bp deletion is associated with diminished fertility and motility of human sperm. , 1995, Biology of reproduction.

[41]  W. R. Bruce,et al.  Chemical induction of sperm abnormalities in mice. , 1975, Proceedings of the National Academy of Sciences of the United States of America.