Measurement of the rate of cholesterol synthesis in various organs of the rat in vivo

A method to measure the absolute values of the rate of cholesterol synthesis in vivo in the organs of the rat has been described. Adult male rats were intravenously infused for 3.5, 6 and 10 h with sodium 1-4 (C)-acetate and the specific activity of expired C0 2 was recorded during the experiment. Sterol radioactivities were measured in plasma, lipoproteins and in various organs, the radioactivities in each organ being corrected for cholesterol transfer. The rate of cholesterol synthesis in the intact rat and in each organ

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