论文信息 - FURTHER STUDIES OF THE TRANSPORT OF PROTEIN TO NERVE ENDINGS *

FURTHER STUDIES OF THE TRANSPORT OF PROTEIN TO NERVE ENDINGS *

Mice were injected intracerebrally with [l‐14C]leucine, and the specific activities of subcellular fractions of brain and effractions of isolated nerve endings were determined. There was a progressive increase in the specific activity of protein associated with isolated nerve endings after incorporation of [l‐14C]leucine into whole brain protein had terminated. Although, the incorporation of [14C]leucine into soluble protein of whole brain did not differ significantly in mice which were 3 months or 1‐year old, the subsequent increase in specific activity of soluble protein isolated from nerve endings was significantly greater in the younger animals; 6‐month‐old mice were intermediate. Therefore, changes in some aspect of the transport of protein to nerve endings is altered even after sexual maturity.

S. Barondes | S. Barondes

[1] S. Barondes,et al. Delayed and sustained effect of acetoxycycloheximide on memory in mice. , 1967, Proceedings of the National Academy of Sciences of the United States of America.

[2] S. Barondes. ON THE SITE OF SYNTHESIS OF THE MITOCHONDRIAL PROTEIN OF NERVE ENDINGS * , 1966, Journal of neurochemistry.

[3] S. Barondes. Delayed Appearance of Labeled Protein in Isolated Nerve Endings and Axoplasmic Flow , 1964, Science.

[4] A. Hegyeli,et al. Temperature Dependence of the Activity of the Antitumor Factor in the Common Clam , 1964, Science.

[5] V. P. Whittaker,et al. The separation of synaptic vesicles from nerve-ending particles ('synaptosomes'). , 1964, The Biochemical journal.

[6] B. Droz,et al. Axonal migration of proteins in the central nervous system and peripheral nerves as shown by radioautography , 1963, The Journal of comparative neurology.

[7] L. Josefsson,et al. Intestinal dipeptidases. IV. Studies on the release and subcellular distribution of intestinal dipeptidases of the mucosa cells of the pig. , 1966, Acta physiologica Scandinavica.