CLINICAL STUDY OF ANTINUCLEAR ANTIBODY AND ITS RELATION TO CLINICAL COURSE

Indirect immunofluorescent test was used to study the clinical significance of antinuclear antibodies (ANA) in 116 systemic lupus erythematosus (SLE) patients. It was found that ANA was present in 96.5% of SLE patients and that their presence could serve as an important laboratory characteristics. A titer of 160 or more could also serve as suggestive evidence for SLE. The chief morphological appearance of ANA was peripheral pattern and homogenous pattern. The peripheral pattern was associated with high titer. A change of titer and pattern were interrelated. A change from homogenous to peripheral pattern indicated a downhill course of the disease, and a change from peripheral to homogenous pattern showed clinical improvement of the disease.

[1]  J. Deng,et al.  A clinical study of antinuclear factor. , 1974, Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association.

[2]  R. Ritchie.  Antinucleolar antibodies. Their frequency and diagnostic association. , 1970, The New England journal of medicine.

[3]  J. S. Beck,et al.  Significance of antinuclear factor in the connective tissue diseases. , 1970, Annals of the Rheumatic Diseases.

[4]  T. Nagasawa,et al.  [Clinical studies on antinuclear factors (ANF)--incidence and titer of ANE in patients with a variety of diseases and serial observations of titer in patients with SLE and scleroderma]. , 1969, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine.

[5]  R. Ritchie.  The clinical significance of titered antinuclear antibodies. , 1967, Arthritis and rheumatism.

[6]  J. S. Beck,et al.  The diagnostic value of an antinuclear antibody test in clinical dermatology. , 1967, Archives of dermatology.

[7]  R. Willkens,et al.  Significance of antinuclear factors in older persons. , 1967, Annals of the rheumatic diseases.

[8]  A. Cannat,et al.  STUDIES ON ANTINUCLEAR ANTIBODIES , 1965, Annals of the New York Academy of Sciences.

[9]  P. Elling,et al.  Anti‐nuclear‐factors (ANF) as Determined by the Immuno‐fluorescent‐antibody Technique , 1965, Acta medica Scandinavica.

[10]  G. Johnson,et al.  ANTINUCLEAR FACTOR IN SYSTEMIC LUPUS ERYTHEMATOSUS. A CONSIDERATION OF THE IMMUNOFLUORESCENT METHOD OF DETECTING ANTINUCLEAR ANTIBODIES, WITH RESULTS OBTAINED IN A FAMILY STUDY. , 1964, Arthritis and rheumatism.

[11]  J. S. Beck,et al.  Auto-Antibodies to Cell Nuclei , 1963, Scottish medical journal.

[12]  Beck Js.  Variations in the morphological patterns of "autoimmune" nuclear fluorescence. , 1961 .

[13]  E. Holborow,et al.  A Clinical Study of Serum Antinuclear Factor , 1961, British medical journal.

[14]  J. Bremner,et al.  Incidence of the Anti-Nuclear Factor in Human Sera , 1960, Annals of the rheumatic diseases.

[15]  J. S. Beck.  Variations in the morphological patterns of "autoimmune" nuclear fluorescence. , 1961, Lancet.