Recovery of human immunodeficiency virus type 1 from semen: minimal impact of stage of infection and current antiviral chemotherapy.

Because exposure to semen is important for the sexual transmission of human immunodeficiency virus type 1 (HIV), the relationship of stage of infection and antiviral chemotherapy to isolation of HIV from semen was investigated. Whereas HIV was isolated from peripheral blood mononuclear cells of all seropositive persons tested, it was isolated from semen in only 11 (32%) of 34 men, including 3 of 6 who were studied sequentially over time. HIV was isolated from 6 (32%) of 19 semen specimens from 14 asymptomatic persons (Centers for Disease Control [CDC] class II or III) and from 10 (28%) of 36 semen specimens from 20 symptomatic patients (CDC class IV). Isolation of HIV from semen did not correlate with CD4+ or CD8+ T lymphocytes counts or zidovudine therapy. Seropositive men may shed HIV in semen early in the course of infection, and zidovudine therapy seems to have no effect on the recovery of HIV and, thus, on the potential for sexual transmission of HIV.

[1]  The transmission of AIDS: the case of the infected cell. , 1988, JAMA.

[2]  G. Friedland,et al.  [Transmission of the human immunodeficiency virus]. , 1987, Voprosy virusologii.

[3]  R. Schooley,et al.  HTLV-III in the semen and blood of a healthy homosexual man. , 1984, Science.

[4]  D. Anderson,et al.  Immunohistologic characterization and quantitation of leukocyte subpopulations in human semen. , 1988, Fertility and sterility.

[5]  B. Safai,et al.  HTLV-III in cells cultured from semen of two patients with AIDS. , 1984, Science.

[6]  J. Ward,et al.  Biologic factors in the sexual transmission of human immunodeficiency virus. , 1989, The Journal of infectious diseases.

[7]  V. Scofield,et al.  Lymphocyte major histocompatibility complex-encoded class II structures may act as sperm receptors. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[8]  R. Redfield,et al.  Frequent transmission of HTLV-III among spouses of patients with AIDS-related complex and AIDS. , 1985, JAMA.

[9]  O. Bagasra,et al.  Interaction of human immunodeficiency virus with human sperm in vitro. , 1988, Journal of acquired immune deficiency syndromes.

[10]  A. Collier,et al.  Plasma viremia in human immunodeficiency virus infection. , 1989, The New England journal of medicine.

[11]  K. Holmes,et al.  Isolation of human immunodeficiency virus from genital ulcers in Nairobi prostitutes. , 1989, The Journal of infectious diseases.

[12]  H. Balfour,et al.  Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex. , 1988, JAMA.

[13]  A. Kiessling,et al.  Detection of human immunodeficiency virus in cell-free seminal fluid. , 1988, Journal of acquired immune deficiency syndromes.