Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins
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J. Rayner | T. Otto | Chengqi Wang | M. Ferdig | R. Jiang | J. Adams | J. Oberstaller | S. Adapa | C. V. Pires | Debora Casandra | Jyotsna Chawla | Min Zhang | R. Jiang
[1] Zbynek Bozdech,et al. Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response , 2022, Communications Biology.
[2] Cyrille Y. Botté,et al. The flexibility of Apicomplexa parasites in lipid metabolism , 2022, PLoS pathogens.
[3] T. Horii,et al. Evidence of Artemisinin-Resistant Malaria in Africa. , 2021, The New England journal of medicine.
[4] Joana C. Silva,et al. Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum , 2021, International journal for parasitology. Drugs and drug resistance.
[5] P. Gilson,et al. Defining the Essential Exportome of the Malaria Parasite. , 2021, Trends in parasitology.
[6] Zbynek Bozdech,et al. Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival , 2021, Nature Communications.
[7] J. Rayner,et al. The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite , 2020, Nature Communications.
[8] H. Kato,et al. A prospective mechanism and source of cholesterol uptake by Plasmodium falciparum-infected erythrocytes co-cultured with HepG2 cells. , 2020, Parasitology international.
[9] Caroline L. Ng,et al. P. falciparum artemisinin resistance: the effect of heme, protein damage, and parasite cell stress response. , 2020, ACS infectious diseases.
[10] E. Hayakawa,et al. Real-time cholesterol sorting in Plasmodium falciparum-erythrocytes as revealed by 3D label-free imaging , 2020, Scientific Reports.
[11] B. Bergmann,et al. A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites , 2020, Science.
[12] S. Ralph,et al. Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance. , 2019, Cell reports.
[13] J. Rayner,et al. Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage , 2019, Cell.
[14] Gennady Korotkevich,et al. Fast gene set enrichment analysis , 2019, bioRxiv.
[15] Remo S. Schmidt,et al. Stochastic protein alkylation by antimalarial peroxides. , 2019, ACS infectious diseases.
[16] A. Stewart,et al. A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice , 2019, Nature Communications.
[17] Steven L Salzberg,et al. Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype , 2019, Nature Biotechnology.
[18] M. Oyama,et al. A High-Resolution Map of SBP1 Interactomes in Plasmodium falciparum-infected Erythrocytes , 2019, iScience.
[19] D. Kwiatkowski,et al. The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background , 2018, Nature Communications.
[20] M. Ferdig,et al. Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum , 2018, BMC Genomics.
[21] P. Gilson,et al. Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export , 2018, PloS one.
[22] D. Hartl,et al. Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility , 2018, Proceedings of the National Academy of Sciences.
[23] P. Preiser,et al. tRNA epitranscriptomics and biased codon are linked to proteome expression in Plasmodium falciparum , 2018, Molecular systems biology.
[24] S. Ralph,et al. Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome , 2018, Nature Communications.
[25] R. Sauer,et al. A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites , 2018, bioRxiv.
[26] D. Goldberg,et al. EXP 2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via , 2018 .
[27] M. Foley,et al. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance , 2018, Proceedings of the National Academy of Sciences.
[28] J. Rayner,et al. Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis , 2018, Science.
[29] K. Williamson,et al. The proteasome as a target to combat malaria: hits and misses. , 2018, Translational research : the journal of laboratory and clinical medicine.
[30] P. Rosenthal,et al. Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance , 2018, The Journal of infectious diseases.
[31] Zbynek Bozdech,et al. Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites , 2018, PLoS pathogens.
[32] Ana Rodriguez,et al. Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency. , 2017, Cell host & microbe.
[33] V. Muralidharan,et al. The Exported Chaperone PfHsp70x Is Dispensable for the Plasmodium falciparum Intraerythrocytic Life Cycle , 2017, mSphere.
[34] M. Bogyo,et al. Protein Degradation Systems as Antimalarial Therapeutic Targets. , 2017, Trends in parasitology.
[35] J. Rayner,et al. Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes , 2017, Cell.
[36] D. Ménard,et al. Plasmodium falciparum Resistance to Artemisinin Derivatives and Piperaquine: A Major Challenge for Malaria Elimination in Cambodia. , 2016, The American journal of tropical medicine and hygiene.
[37] D. Saunders,et al. Ex vivo piperaquine resistance developed rapidly in Plasmodium falciparum isolates in northern Cambodia compared to Thailand , 2016, Malaria Journal.
[38] M. Blackman,et al. Regulation and Essentiality of the StAR-related Lipid Transfer (START) Domain-containing Phospholipid Transfer Protein PFA0210c in Malaria Parasites* , 2016, The Journal of Biological Chemistry.
[39] Manuel Llinás,et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond , 2016, PLoS pathogens.
[40] J. Rayner,et al. Quantitative insertion-site sequencing (QIseq) for high throughput phenotyping of transposon mutants , 2016, Genome research.
[41] Zbynek Bozdech,et al. DNA damage regulation and its role in drug-related phenotypes in the malaria parasites , 2016, Scientific Reports.
[42] J. Hemingway,et al. Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 , 2016, Proceedings of the National Academy of Sciences.
[43] L. Tilley,et al. Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins , 2016, Journal of Cell Science.
[44] Bin Liu,et al. Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum , 2015, Nature Communications.
[45] Geoffrey H. Siwo,et al. Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery , 2015, Scientific Reports.
[46] Zbynek Bozdech,et al. TARGETING THE CELL STRESS RESPONSE OF PLASMODIUM FALCIPARUM TO OVERCOME ARTEMISININ RESISTANCE , 2015 .
[47] Scott Emrich,et al. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria , 2015, Nature.
[48] Frank Schwach,et al. A Genome-Scale Vector Resource Enables High-Throughput Reverse Genetic Screening in a Malaria Parasite , 2015, Cell host & microbe.
[49] John C. Tan,et al. Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia. , 2015, The Journal of infectious diseases.
[50] R. Hallett,et al. The Mu Subunit of Plasmodium falciparum Clathrin-Associated Adaptor Protein 2 Modulates In Vitro Parasite Response to Artemisinin and Quinine , 2015, Antimicrobial Agents and Chemotherapy.
[51] D. Kwiatkowski,et al. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance , 2015, Science.
[52] Gilean McVean,et al. Genetic architecture of artemisinin-resistant Plasmodium falciparum , 2015, Nature Genetics.
[53] L. Imlay,et al. Isoprenoid Metabolism in Apicomplexan Parasites , 2014, Current Clinical Microbiology Reports.
[54] E. Ashley,et al. Artemisinin resistance – modelling the potential human and economic costs , 2014, Malaria Journal.
[55] Anusha M. Gopalakrishnan,et al. Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species , 2014, Antimicrobial Agents and Chemotherapy.
[56] D. Goldberg,et al. PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes , 2014, Nature.
[57] T. Clark,et al. Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT , 2014, The Journal of infectious diseases.
[58] M. Gatton,et al. Fatty Acid Synthesis and Pyruvate Metabolism Pathways Remain Active in Dihydroartemisinin-Induced Dormant Ring Stages of Plasmodium falciparum , 2014, Antimicrobial Agents and Chemotherapy.
[59] Zhijian J. Chen,et al. K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking. , 2014, Molecular cell.
[60] L. Kats,et al. An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells. , 2014, International journal for parasitology.
[61] G. Biagini,et al. The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development☆ , 2014, Trends in parasitology.
[62] B. Genton,et al. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria , 2013, Nature.
[63] C. Sibley. Tracking artemisinin resistance in Plasmodium falciparum. , 2013, The Lancet. Infectious diseases.
[64] B. Striepen,et al. Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans. , 2013, Progress in lipid research.
[65] K. Haldar,et al. Identification of a Plasmodium falciparum Phospholipid Transfer Protein* , 2013, The Journal of Biological Chemistry.
[66] T. Gilberger,et al. Identification of New PNEPs Indicates a Substantial Non-PEXEL Exportome and Underpins Common Features in Plasmodium falciparum Protein Export , 2013, PLoS pathogens.
[67] N. Azas,et al. A decade of Plasmodium falciparum metabolic pathways of therapeutic interest to develop new selective antimalarial drugs. , 2013, Mini reviews in medicinal chemistry.
[68] Wei Shi,et al. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features , 2013, Bioinform..
[69] A. Cowman,et al. Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome , 2013, Traffic.
[70] C. Karema,et al. Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking , 2013, Malaria Journal.
[71] C. Karema,et al. Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking , 2013, Malaria Journal.
[72] T. Egan,et al. Insights into the role of heme in the mechanism of action of antimalarials. , 2013, ACS chemical biology.
[73] P. Gilson,et al. Plasmodium falciparum‐encoded exported hsp70/hsp40 chaperone/co‐chaperone complexes within the host erythrocyte , 2012, Cellular microbiology.
[74] Leann Tilley,et al. Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion , 2011, Proceedings of the National Academy of Sciences.
[75] J. Derisi,et al. RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts , 2011, Nucleic acids research.
[76] Helga Thorvaldsdóttir,et al. Integrative Genomics Viewer , 2011, Nature Biotechnology.
[77] Ravikant Ranjan,et al. PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking. , 2010, Blood.
[78] Aaron R. Quinlan,et al. BEDTools: a flexible suite of utilities for comparing genomic features , 2010, Bioinform..
[79] E. Ashley,et al. Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies , 2009, Malaria Journal.
[80] Gonçalo R. Abecasis,et al. The Sequence Alignment/Map format and SAMtools , 2009, Bioinform..
[81] K. Haldar,et al. The Malaria Secretome: From Algorithms to Essential Function in Blood Stage Infection , 2008, PLoS pathogens.
[82] J. Lelièvre,et al. Trioxaquines and Heme-Artemisinin Adducts Inhibit the In Vitro Formation of Hemozoin Better than Chloroquine , 2007, Antimicrobial Agents and Chemotherapy.
[83] P. T. Englund,et al. A fatty-acid synthesis mechanism specialized for parasitism , 2007, Nature Reviews Microbiology.
[84] R. Shoemaker. The NCI60 human tumour cell line anticancer drug screen , 2006, Nature Reviews Cancer.
[85] C. Tomasetto,et al. Give lipids a START: the StAR-related lipid transfer (START) domain in mammals , 2005, Journal of Cell Science.
[86] Melanie Rug,et al. Targeting Malaria Virulence and Remodeling Proteins to the Host Erythrocyte , 2004, Science.
[87] Travis Harrison,et al. A Host-Targeting Signal in Virulence Proteins Reveals a Secretome in Malarial Infection , 2004, Science.
[88] Fuencisla Matesanz,et al. The C-terminal domain of the Plasmodium falciparum acyl-CoA synthetases PfACS1 and PfACS3 functions as ligand for ankyrin. , 2003, Molecular and biochemical parasitology.
[89] J. Breslow,et al. StAR-related Lipid Transfer (START) Proteins: Mediators of Intracellular Lipid Metabolism* , 2003, Journal of Biological Chemistry.
[90] S. Ralph,et al. A Type II Pathway for Fatty Acid Biosynthesis Presents Drug Targets in Plasmodium falciparum , 2003, Antimicrobial Agents and Chemotherapy.
[91] Thomas D. Schmittgen,et al. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.
[92] J. Hurley,et al. Structure and lipid transport mechanism of a StAR-related domain , 2000, Nature Structural Biology.
[93] T. K. Dien,et al. Clinical Pharmacology and Therapeutic Potential of Artemisinin and its Derivatives in the Treatment of Malaria , 1996, Drugs.
[94] H. Vial,et al. Correlation of the efficiency of fatty acid derivatives in suppressing Plasmodium falciparum growth in culture with their inhibitory effect on acyl-CoA synthetase activity. , 1988, Molecular and biochemical parasitology.
[95] H. Vial,et al. Acyl-CoA synthetase activity in Plasmodium knowlesi-infected erythrocytes displays peculiar substrate specificities. , 1988, Biochimica et biophysica acta.
[96] G. McFadden,et al. Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts. , 2015, Molecular and biochemical parasitology.
[97] C. Tomasetto,et al. START ships lipids across interorganelle space. , 2014, Biochimie.
[98] A. Alcina,et al. The Plasmodium falciparum fatty acyl-CoA synthetase family (PfACS) and differential stage-specific expression in infected erythrocytes. , 2003, Molecular and biochemical parasitology.