The current approach of the Epilepsy Therapy Screening Program contract site for identifying improved therapies for the treatment of pharmacoresistant seizures in epilepsy
暂无分享,去创建一个
[1] M. Barton,et al. Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy , 2001, Epilepsy Research.
[2] D. Reddy,et al. Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy. , 2017, Biochimica et biophysica acta. Molecular basis of disease.
[3] I. Soltesz,et al. On-demand optogenetic control of spontaneous seizures in temporal lobe epilepsy , 2013, Nature Communications.
[4] W. Löscher,et al. Antiepileptic drug resistant rats differ from drug responsive rats in GABAA receptor subunit expression in a model of temporal lobe epilepsy , 2008, Neurobiology of Disease.
[5] K. Wilcox,et al. Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy , 2016, Journal of neuropathology and experimental neurology.
[6] A. Adams,et al. Phenytoin- and carbamazepine-resistant spontaneous bursting in rat entorhinal cortex is blocked by retigabine in vitro , 2007, Epilepsy Research.
[7] Ting Wu,et al. Mode of seizure inhibition by sodium channel blockers, an SV2A ligand, and an AMPA receptor antagonist in a rat amygdala kindling model , 2019, Epilepsy Research.
[8] M. Barker-Haliski,et al. Lamotrigine‐resistant corneal‐kindled mice: A model of pharmacoresistant partial epilepsy for moderate‐throughput drug discovery , 2018, Epilepsia.
[9] K. Wilcox,et al. Evaluating an Etiologically Relevant Platform for Therapy Development for Temporal Lobe Epilepsy: Effects of Carbamazepine and Valproic Acid on Acute Seizures and Chronic Behavioral Comorbidities in the Theiler’s Murine Encephalomyelitis Virus Mouse Model , 2015, The Journal of Pharmacology and Experimental Therapeutics.
[10] K. Wilcox,et al. Recurrent epileptiform discharges in the medial entorhinal cortex of kainate‐treated rats are differentially sensitive to antiseizure drugs , 2018, Epilepsia.
[11] Roy M. Smeal,et al. Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy , 2017, eNeuro.
[12] Wolfgang Löscher,et al. Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABAA receptor ligand binding in a model of temporal lobe epilepsy , 2006, Neurobiology of Disease.
[13] H. White,et al. Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats , 2013, Epilepsy Research.
[14] E. Ben-Menachem,et al. Issues related to development of new antiseizure treatments , 2013, Epilepsia.
[15] F. Dudek,et al. Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate‐treated rats , 1997 .
[16] S. Charpier,et al. Involvement of the Thalamic Parafascicular Nucleus in Mesial Temporal Lobe Epilepsy , 2010, The Journal of Neuroscience.
[17] Ivan Soltesz,et al. Closed-loop optogenetic intervention in mice , 2013, Nature Protocols.
[18] Sreekala S. Nampoothiri,et al. Rodent Gymnastics: Neurobehavioral Assays in Ischemic Stroke , 2016, Molecular Neurobiology.
[19] Y. Lamberty,et al. Use of epileptic animals for adverse effect testing , 2002, Epilepsy Research.
[20] Ahmad N. Abou Tayoun,et al. Understanding Genotypes and Phenotypes in Epileptic Encephalopathies , 2016, Molecular Syndromology.
[21] H. Merritt,et al. EXPERIMENTAL DETERMINATION OF THE ANTICONVULSANT PROPERTIES OF SOME PHENYL DERIVATIVES. , 1937, Science.
[22] Dipan C. Patel,et al. Cannabidiol reduces seizures following CNS infection with Theiler's murine encephalomyelitis virus , 2019, Epilepsia open.
[23] R. Post,et al. Unidirectional Cross‐tolerance from Levetiracetam to Carbamazepine in Amygdala‐kindled Seizures , 2003, Epilepsia.
[24] D. J. Doty,et al. Infiltrating Macrophages Are Key to the Development of Seizures following Virus Infection , 2012, Journal of Virology.
[25] N. Lazarov,et al. Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy , 2014, Pharmacology Biochemistry and Behavior.
[26] J. Conry. Pharmacologic Treatment of the Catastrophic Epilepsies , 2004, Epilepsia.
[27] J. Libbey,et al. Innate but not adaptive immune responses contribute to behavioral seizures following viral infection , 2010, Epilepsia.
[28] J. Kehne,et al. Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP) , 2017, Neurochemical Research.
[29] K. Wilcox,et al. Increased coupling and altered glutamate transport currents in astrocytes following kainic-acid-induced status epilepticus , 2010, Neurobiology of Disease.
[30] Xinnian Chen,et al. Disordered breathing in a mouse model of Dravet syndrome , 2018, bioRxiv.
[31] K. Thomson,et al. Development and pharmacologic characterization of the rat 6 Hz model of partial seizures , 2017, Epilepsia.
[32] U. Heinemann,et al. Increased susceptibility to acetylcholine in the entorhinal cortex of pilocarpine-treated rats involves alterations in KCNQ channels , 2013, Neurobiology of Disease.
[33] David K. Wright,et al. Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau. , 2016, Brain : a journal of neurology.
[34] L. Zeng,et al. The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy , 2009, The Journal of Neuroscience.
[35] K. Wilcox,et al. Impaired cognitive ability and anxiety-like behavior following acute seizures in the Theiler's virus model of temporal lobe epilepsy , 2014, Neurobiology of Disease.
[36] D. Gauvin,et al. The standardized functional observational battery: Its intrinsic value remains in the instrument of measure: The rat. , 2016, Journal of pharmacological and toxicological methods.
[37] Massimo Avoli,et al. The kainic acid model of temporal lobe epilepsy , 2013, Neuroscience & Biobehavioral Reviews.
[38] K. Akcali,et al. The Role of bcl‐2 Family of Genes During Kindling , 2005, Epilepsia.
[39] P. Kwan,et al. Drug-resistant epilepsy. , 2011, The New England journal of medicine.
[40] W. Löscher,et al. The intrahippocampal kainate mouse model of mesial temporal lobe epilepsy: Lack of electrographic seizure‐like events in sham controls , 2017, Epilepsia open.
[41] J. Kehne,et al. The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP) , 2017, Neurochemical Research.
[42] H. Potschka. Animal models of drug-resistant epilepsy , 2012, Epileptic disorders : international epilepsy journal with videotape.
[43] J. Rausch,et al. The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy , 2017, Epilepsia.
[44] S. Hatakeyama,et al. Perampanel: A novel, orally active, noncompetitive AMPA‐receptor antagonist that reduces seizure activity in rodent models of epilepsy , 2011, Epilepsia.
[45] J. Libbey,et al. Seizures following picornavirus infection , 2008, Epilepsia.
[46] Y. Ben-Ari,et al. Kainate, a double agent that generates seizures: two decades of progress , 2000, Trends in Neurosciences.
[47] K. Wilcox,et al. Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy , 2017, Neurochemical Research.
[48] K. Wilcox,et al. A new derivative of valproic acid amide possesses a broad‐spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage , 2012, Epilepsia.
[49] R. Post,et al. Lamotrigine Treatment During Amygdala‐Kindled Seizure Development Fails to Inhibit Seizures and Diminishes Subsequent Anticonvulsant Efficacy , 2000, Epilepsia.
[50] Philip A. Williams,et al. Use of Chronic Epilepsy Models in Antiepileptic Drug Discovery: The Effect of Topiramate on Spontaneous Motor Seizures in Rats with Kainate‐induced Epilepsy , 2005, Epilepsia.
[51] P. Klein,et al. A review of the pharmacology and clinical efficacy of brivaracetam , 2018, Clinical pharmacology : advances and applications.
[52] A. Depaulis,et al. Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy , 1999, Neuroscience.
[53] S. Jackson,et al. Assessing the predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trials. , 2016, Regulatory toxicology and pharmacology : RTP.
[54] Patrick Kwan,et al. Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: A 30-Year Longitudinal Cohort Study , 2017, JAMA neurology.
[55] H. Houston Merritt,et al. A NEW SERIES OF ANTICONVULSANT DRUGS TESTED BY EXPERIMENTS ON ANIMALS , 1938 .
[56] M. Avoli,et al. Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration , 2016, Journal of Neuroscience Methods.
[57] K. Thomson,et al. Evaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine‐resistant amygdala kindling model , 2019, Epilepsia open.
[58] Shumei S. Sun,et al. Human herpesvirus 6 and 7 in febrile status epilepticus: The FEBSTAT study , 2012, Epilepsia.
[59] A. Depaulis,et al. Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy , 2016, CNS neuroscience & therapeutics.
[60] W. Löscher. The Search for New Screening Models of Pharmacoresistant Epilepsy: Is Induction of Acute Seizures in Epileptic Rodents a Suitable Approach? , 2016, Neurochemical Research.
[61] V. Moser,et al. The Irwin Test and Functional Observational Battery (FOB) for Assessing the Effects of Compounds on Behavior, Physiology, and Safety Pharmacology in Rodents , 2018, Current protocols in pharmacology.
[62] R. Fujinami,et al. Development of Postinfection Epilepsy After Theiler's Virus Infection of C57BL/6 Mice , 2010, Journal of neuropathology and experimental neurology.
[63] R. Fujinami,et al. Theiler’s virus infection chronically alters seizure susceptibility , 2009, Epilepsia.
[64] S. Sombati,et al. Characterization of spontaneous recurrent epileptiform discharges in hippocampal–entorhinal cortical slices prepared from chronic epileptic animals , 2011, Seizure.
[65] W. Löscher,et al. Brain inflammation, neurodegeneration and seizure development following picornavirus infection markedly differ among virus and mouse strains and substrains , 2016, Experimental Neurology.