The behavioral economics of substance use disorders: reinforcement pathologies and their repair.

The field of behavioral economics has made important inroads into the understanding of substance use disorders through the concept of reinforcer pathology. Reinforcer pathology refers to the joint effects of (a) the persistently high valuation of a reinforcer, broadly defined to include tangible commodities and experiences, and/or (b) the excessive preference for the immediate acquisition or consumption of a commodity despite long-term negative outcomes. From this perspective, reinforcer pathology results from the recursive interactions of endogenous person-level variables and exogenous environment-level factors. The current review describes the basic principles of behavioral economics that are central to reinforcer pathology, the processes that engender reinforcer pathology, and the approaches and procedures that can repair reinforcement pathologies. The overall goal of this review is to present a new understanding of substance use disorders as viewed by recent advances in behavioral economics.

[1]  K. Kendler,et al.  Recent advances in the genetic epidemiology and molecular genetics of substance use disorders , 2012, Nature Neuroscience.

[2]  Tomohiro Miyakawa,et al.  Two-month stability of hyperbolic discount rates for delayed monetary gains in abstinent inpatient alcoholics. , 2007, Neuro endocrinology letters.

[3]  J. MacKillop,et al.  Behavioral economic analysis of cue-elicited craving for tobacco: a virtual reality study. , 2012, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[4]  R. Vuchinich,et al.  Using behavioral theories of choice to predict drinking outcomes following a brief intervention. , 2005, Experimental and clinical psychopharmacology.

[5]  W K Bickel,et al.  Impulsive and self-control choices in opioid-dependent patients and non-drug-using control participants: drug and monetary rewards. , 1997, Experimental and clinical psychopharmacology.

[6]  Drazen Prelec,et al.  A Theory of Addiction , 1992 .

[7]  James MacKillop,et al.  Reliability and validity of a demand curve measure of alcohol reinforcement. , 2009, Experimental and clinical psychopharmacology.

[8]  Warren K Bickel,et al.  Congruence of BOLD Response across Intertemporal Choice Conditions: Fictive and Real Money Gains and Losses , 2009, The Journal of Neuroscience.

[9]  James MacKillop,et al.  Validity of a demand curve measure of nicotine reinforcement with adolescent smokers. , 2011, Drug and alcohol dependence.

[10]  Gordon D. Logan,et al.  The Ecological Validity of Delay Aversion and Response Inhibition as Measures of Impulsivity in AD/HD: A Supplement to the NIMH Multimodal Treatment Study of AD/HD , 2001, Journal of abnormal child psychology.

[11]  Mark B. Powers,et al.  Behavioral couples therapy (BCT) for alcohol and drug use disorders: a meta-analysis. , 2008, Clinical psychology review.

[12]  Matthew W. Johnson,et al.  Delay discounting in currently using and currently abstinent cocaine-dependent outpatients and non-drug-using matched controls. , 2006, Addictive behaviors.

[13]  R. Vuchinich.  Alcohol abuse as molar choice: An update of a 1982 proposal. , 1995 .

[14]  L. Bierut.  Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25. , 2010, Trends in pharmacological sciences.

[15]  L. Green,et al.  Temporal discounting and preference reversals in choice between delayed outcomes , 1994, Psychonomic bulletin & review.

[16]  R. Vuchinich,et al.  Hyperbolic temporal discounting in social drinkers and problem drinkers. , 1998, Experimental and clinical psychopharmacology.

[17]  G. Badger,et al.  Effects of simulated employment and recreation on drug taking: A behavioral economic analysis. , 1995 .

[18]  Matthew W. Johnson,et al.  Effects of varenicline on abstinence and smoking reward following a programmed lapse. , 2013, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[19]  A. Aleman,et al.  Cognitive rehabilitation in schizophrenia: a quantitative analysis of controlled studies , 2003, Psychopharmacology.

[20]  B. Franke,et al.  Behavioral and Brain Functions , 2005 .

[21]  R. Paxton.  Deposit contracts with smokers: varying frequency and amount of repayments. , 1981, Behaviour research and therapy.

[22]  Xianghua Luo,et al.  Analysis of cigarette purchase task instrument data with a left-censored mixed effects model. , 2013, Experimental and clinical psychopharmacology.

[23]  W. Bickel,et al.  The neuroeconomics of nicotine dependence: A preliminary functional magnetic resonance imaging study of delay discounting of monetary and cigarette rewards in smokers , 2012, Psychiatry Research: Neuroimaging.

[24]  J. Flory,et al.  Delay discounting and smoking: association with the Fagerström Test for Nicotine Dependence but not cigarettes smoked per day. , 2008, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[25]  N. Singh,et al.  Smoking cessation through cigarette-fading, self-recording, and contracting: treatment, maintenance and long-term followup. , 1988, Addictive behaviors.

[26]  Todd L McKerchar,et al.  Delay discounting is associated with treatment response among cocaine-dependent outpatients. , 2011, Experimental and clinical psychopharmacology.

[27]  W. Bickel,et al.  A comparison of two algorithms in computerized temporal discounting procedures , 2007, Behavioural Processes.

[28]  Bethany R Raiff,et al.  Delay discounting of potentially real and hypothetical rewards: II. Between- and within-subject comparisons. , 2004, Experimental and clinical psychopharmacology.

[29]  C. O'brien,et al.  A range of research-based pharmacotherapies for addiction. , 1997, Science.

[30]  G. Badger,et al.  Changes in the relative reinforcing effects of cigarette smoking as a function of initial abstinence , 2009, Psychopharmacology.

[31]  R. Paxton.  Prolonging the effects of deposit contracts with smokers. , 1983, Behaviour research and therapy.

[32]  Mark D'Esposito,et al.  Impulsive responding in alcoholics. , 2005, Alcoholism, clinical and experimental research.

[33]  R. Vuchinich,et al.  Significance of a behavioral economic index of reward value in predicting drinking problem resolution. , 2006, Journal of consulting and clinical psychology.

[34]  G. Badger,et al.  Achieving cocaine abstinence with a behavioral approach. , 1993, The American journal of psychiatry.

[35]  Gregory J. Madden,et al.  Impulsivity (delay discounting) as a predictor of acquisition of IV cocaine self-administration in female rats , 2005, Psychopharmacology.

[36]  S R Hursh,et al.  Economic concepts for the analysis of behavior. , 1980, Journal of the experimental analysis of behavior.

[37]  M. Nader,et al.  Effects of increasing the magnitude of an alternative reinforcer on drug choice in a discrete-trials choice procedure , 2005, Psychopharmacology.

[38]  L. Epstein,et al.  Young adult smoking: what factors differentiate ex-smokers, smoking cessation treatment seekers and nontreatment seekers? , 2009, Addictive behaviors.

[39]  Kris N Kirby,et al.  Heroin and cocaine abusers have higher discount rates for delayed rewards than alcoholics or non-drug-using controls. , 2004, Addiction.

[40]  K. Silverman,et al.  A reinforcement-based therapeutic workplace for the treatment of drug abuse: six-month abstinence outcomes. , 2001, Experimental and clinical psychopharmacology.

[41]  Steven R Hursh,et al.  Behavioral economics and empirical public policy. , 2013, Journal of the experimental analysis of behavior.

[42]  M. Wagner,et al.  Obese and nonobese individuals: behavioral and personality characteristics. , 1984, Addictive behaviors.

[43]  K. Silverman,et al.  Employment-based abstinence reinforcement as a maintenance intervention for the treatment of cocaine dependence: post-intervention outcomes. , 2011, Addiction.

[44]  B. Alexander,et al.  The effect of housing and gender on morphine self-administration in rats , 1978, Psychopharmacology.

[45]  W. Bickel,et al.  Intertemporal Decision-Making for a Group , 2010, The Psychological record.

[46]  G. Heyman,et al.  Delay discounting in college cigarette chippers , 2006, Behavioural pharmacology.

[47]  Reid D. Landes,et al.  Restricted psychological horizon in active methamphetamine users: future, past, probability, and social discounting , 2012, Behavioural pharmacology.

[48]  D. Hommer,et al.  Impulsivity in abstinent alcohol-dependent patients: relation to control subjects and type 1-/type 2-like traits. , 2004, Alcohol.

[49]  T. Robbins,et al.  Behavioral models of impulsivity in relation to ADHD: Translation between clinical and preclinical studies , 2006, Clinical psychology review.

[50]  Warren K Bickel,et al.  Within-subject comparison of real and hypothetical money rewards in delay discounting. , 2002, Journal of the experimental analysis of behavior.

[51]  G. Badger,et al.  SOCIAL DISCOUNTING AND CIGARETTE SMOKING DURING PREGNANCY. , 2012, Journal of behavioral decision making.

[52]  R. Niaura,et al.  Behavioral economic analysis of withdrawal- and cue-elicited craving for tobacco: an initial investigation. , 2012, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[53]  G. Madden,et al.  Delay discounting of real and hypothetical rewards. , 2003, Experimental and clinical psychopharmacology.

[54]  J. Richards,et al.  Delay discounting and probability discounting as related to cigarette smoking status in adults , 2004, Behavioural Processes.

[55]  N. Heather,et al.  Choice, behavioral economics, and addiction , 2003 .

[56]  George Loewenstein,et al.  Mild opioid deprivation increases the degree that opioid-dependent outpatients discount delayed heroin and money , 2002, Psychopharmacology.

[57]  Gal Meiri,et al.  Cortical activation during delay discounting in abstinent methamphetamine dependent individuals , 2008, Psychopharmacology.

[58]  Mikhail N. Koffarnus,et al.  Individual differences in discount rate are associated with demand for self‐administered cocaine, but not sucrose , 2013, Addiction biology.

[59]  Stacey B. Daughters,et al.  ACT HEALTHY: A Combined Cognitive-Behavioral Depression and Medication Adherence Treatment for HIV-Infected Substance Users. , 2010, Cognitive and behavioral practice.

[60]  Daniel D. Holt,et al.  Is discounting impulsive? Evidence from temporal and probability discounting in gambling and non-gambling college students , 2003, Behavioural Processes.

[61]  Carla H. Lagorio,et al.  Delay discounting of real and hypothetical rewards III: Steady-state assessments, forced-choice trials, and all real rewards , 2005, Behavioural Processes.

[62]  Jennifer M. Mitchell,et al.  Immediate Reward Bias in Humans: Fronto-Parietal Networks and a Role for the Catechol-O-Methyltransferase 158Val/Val Genotype , 2007, The Journal of Neuroscience.

[63]  L. Diergaarde,et al.  Poor impulse control predicts inelastic demand for nicotine but not alcohol in rats , 2012, Addiction biology.

[64]  G. Badger,et al.  An experimental examination of the initial weeks of abstinence in cigarette smokers. , 2004, Experimental and clinical psychopharmacology.

[65]  J. Giannetta,et al.  Working memory ability predicts trajectories of early alcohol use in adolescents: the mediational role of impulsivity. , 2013, Addiction.

[66]  Matthew W. Johnson,et al.  The Sexual Discounting Task: HIV risk behavior and the discounting of delayed sexual rewards in cocaine dependence. , 2012, Drug and alcohol dependence.

[67]  Jesse Dallery,et al.  A deposit contract method to deliver abstinence reinforcement for cigarette smoking. , 2008, Journal of applied behavior analysis.

[68]  N. Petry,et al.  What do we get for our money? Cost-effectiveness of adding contingency management. , 2007, Addiction.

[69]  C. Perry,et al.  How did Project Northland reduce alcohol use among young adolescents? Analysis of mediating variables. , 2001, Health education research.

[70]  Reinout W. Wiers,et al.  Getting a Grip on Drinking Behavior , 2011, Psychological science.

[71]  J. McGeary,et al.  Behavioral economic analysis of cue-elicited craving for alcohol. , 2010, Addiction.

[72]  B. Reynolds,et al.  Delay discounting as a mediator of the relationship between perceived stress and cigarette smoking status in adolescents , 2009, Behavioural pharmacology.

[73]  John McGeary,et al.  Delay discounting, locus of control, and cognitive impulsiveness independently predict tobacco dependence treatment outcomes in a highly dependent, lower socioeconomic group of smokers. , 2012, The American journal on addictions.

[74]  B. Setlow,et al.  Self-administered cocaine causes long-lasting increases in impulsive choice in a delay discounting task. , 2010, Behavioral neuroscience.

[75]  B. J. Betts,et al.  Non-commercial Research and Educational Use including without Limitation Use in Instruction at Your Institution, Sending It to Specific Colleagues That You Know, and Providing a Copy to Your Institution's Administrator. All Other Uses, Reproduction and Distribution, including without Limitation Comm , 2006 .

[76]  M. Yücel,et al.  Responsiveness to drug cues and natural rewards in opiate addiction: associations with later heroin use. , 2009, Archives of general psychiatry.

[77]  T. Robbins,et al.  Similar Effects of the Selective Noradrenaline Reuptake Inhibitor Atomoxetine on Three Distinct Forms of Impulsivity in the Rat , 2008, Neuropsychopharmacology.

[78]  J. MacKillop,et al.  Further validation of a cigarette purchase task for assessing the relative reinforcing efficacy of nicotine in college smokers. , 2008, Experimental and clinical psychopharmacology.

[79]  G. Badger,et al.  A pilot study on voucher-based incentives to promote abstinence from cigarette smoking during pregnancy and postpartum. , 2004, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[80]  W. Bickel,et al.  Behavioral economics of drug self-administration. I. Functional equivalence of response requirement and drug dose. , 1990, Life sciences.

[81]  Justin J Anker,et al.  Modeling risk factors for nicotine and other drug abuse in the preclinical laboratory. , 2009, Drug and alcohol dependence.

[82]  R. Elliott,et al.  Breaking the Cigarette Habit: Effects of a Technique Involving Threatened Loss of Money , 1968 .

[83]  David P Jarmolowicz,et al.  Changing delay discounting in the light of the competing neurobehavioral decision systems theory: a review. , 2013, Journal of the experimental analysis of behavior.

[84]  Andrew Goudie,et al.  Delay discounting and the behavioural economics of cigarette purchases in smokers: the effects of nicotine deprivation , 2006, Psychopharmacology.

[85]  S. M. Alessi,et al.  Pathological gambling severity is associated with impulsivity in a delay discounting procedure , 2003, Behavioural Processes.

[86]  W. van den Brink,et al.  Experiences with an Outpatient Relapse Program (Community Reinforcement Approach) Combined with Naltrexone in the Treatment of Opioid-Dependence: Effect on Addictive Behaviors and the Predictive Value of Psychiatric Comorbidity , 2003, European Addiction Research.

[87]  W. Bickel,et al.  Probability discounting among cigarette smokers and nonsmokers: molecular analysis discerns group differences , 2007, Behavioural pharmacology.

[88]  W. Bickel,et al.  Novel Models of Intertemporal Valuation: Past and Future Outcomes. , 2009, Journal of neuroscience, psychology, and economics.

[89]  W. Bickel,et al.  A behavioral approach to achieving initial cocaine abstinence. , 1991, The American journal of psychiatry.

[90]  S. Lawyer,et al.  Probability and delay discounting of hypothetical sexual outcomes , 2010, Behavioural Processes.

[91]  W. Bickel,et al.  Deconstructing relative reinforcing efficacy and situating the measures of pharmacological reinforcement with behavioral economics: a theoretical proposal , 2000, Psychopharmacology.

[92]  N. Volkow,et al.  The neural basis of addiction: a pathology of motivation and choice. , 2005, The American journal of psychiatry.

[93]  Claudia González-Vallejo,et al.  Temporal discounting in heroin-dependent patients: no sign effect, weaker magnitude effect, and the relationship with inhibitory control. , 2012, Experimental and clinical psychopharmacology.

[94]  J. MacKillop,et al.  Understanding naltrexone mechanism of action and pharmacogenetics in Asian Americans via behavioral economics: a preliminary study. , 2012, Experimental and clinical psychopharmacology.

[95]  K. Carey,et al.  Relationships between binge drinking and substance-free reinforcement in a sample of college students: a preliminary investigation. , 2003, Addictive behaviors.

[96]  P. Monti,et al.  Motivational interviewing for incarcerated adolescents: effects of depressive symptoms on reducing alcohol and marijuana use after release. , 2011, Journal of studies on alcohol and drugs.

[97]  H. Liddle,et al.  Five outpatient treatment models for adolescent marijuana use: a description of the Cannabis Youth Treatment Interventions. , 2002, Addiction.

[98]  M. Martinetti,et al.  Academic constraints on alcohol consumption in college students: a behavioral economic analysis. , 2012, Experimental and clinical psychopharmacology.

[99]  Taiki Takahashi,et al.  Discounting delayed and probabilistic monetary gains and losses by smokers of cigarettes , 2005, Psychopharmacology.

[100]  JaneR . Taylor,et al.  Chronic Corticosterone Exposure during Adolescence Reduces Impulsive Action but Increases Impulsive Choice and Sensitivity to Yohimbine in Male Sprague-Dawley Rats , 2012, Neuropsychopharmacology.

[101]  A. Heath,et al.  Heritability of Delay Discounting in Adolescence: A Longitudinal Twin Study , 2011, Behavior genetics.

[102]  L. Epstein,et al.  Behavioral economic predictors of overweight children's weight loss. , 2012, Journal of consulting and clinical psychology.

[103]  R. Vuchinich,et al.  Predicting natural resolution of alcohol-related problems: a prospective behavioral economic analysis. , 2002, Experimental and clinical psychopharmacology.

[104]  L. Ray,et al.  Effects of naltrexone on alcohol sensitivity and genetic moderators of medication response: a double-blind placebo-controlled study. , 2007, Archives of general psychiatry.

[105]  Matthew W. Johnson,et al.  Delay discounting in current and never-before cigarette smokers: similarities and differences across commodity, sign, and magnitude. , 2003, Journal of abnormal psychology.

[106]  K. Cosgrove,et al.  Effects of a non-drug reinforcer, saccharin, on oral self-administration of phencyclidine in male and female rhesus monkeys , 2003, Psychopharmacology.

[107]  L. Epstein,et al.  Reinforcement pathology and obesity. , 2011, Current drug abuse reviews.

[108]  E Paul Wileyto,et al.  Does delay discounting play an etiological role in smoking or is it a consequence of smoking? , 2009, Drug and alcohol dependence.

[109]  G. Badger,et al.  Unit price as a useful metric in analyzing effects of reinforcer magnitude. , 1993, Journal of the experimental analysis of behavior.

[110]  Barry Setlow,et al.  Cocaine exposure causes long-term increases in impulsive choice. , 2007, Behavioral neuroscience.

[111]  L. Epstein,et al.  Comparison between two measures of delay discounting in smokers. , 2003, Experimental and clinical psychopharmacology.

[112]  Reid D Landes,et al.  Temporal and probability discounting by cigarette smokers following acute smoking abstinence. , 2012, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[113]  J. Audrain-McGovern,et al.  Declining alternative reinforcers link depression to young adult smoking. , 2011, Addiction.

[114]  Gary J. Badger,et al.  Buprenorphine dosing every 1, 2, or 3 days in opioid-dependent patients , 1999, Psychopharmacology.

[115]  James MacKillop,et al.  Integrating behavioral economics and behavioral genetics: delayed reward discounting as an endophenotype for addictive disorders. , 2013, Journal of the experimental analysis of behavior.

[116]  Leonard H. Epstein,et al.  Delay discounting moderates the effect of food reinforcement on energy intake among non-obese women , 2010, Appetite.

[117]  A. Odum.  Delay discounting: Trait variable? , 2011, Behavioural Processes.

[118]  K. Brady,et al.  Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals. , 2003, Experimental and clinical psychopharmacology.

[119]  E B Ebbesen,et al.  Cognitive and attentional mechanisms in delay of gratification. , 1972, Journal of personality and social psychology.

[120]  M. Bardo,et al.  Differences in impulsivity on a delay-discounting task predict self-administration of a low unit dose of methylphenidate in rats , 2009, Behavioural pharmacology.

[121]  G. Koob,et al.  The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. , 2006, Addiction.

[122]  N. Petry,et al.  Randomized trial of contingent prizes versus vouchers in cocaine-using methadone patients. , 2007, Journal of consulting and clinical psychology.

[123]  Stacey B. Daughters,et al.  Application of the social action theory to understand factors associated with risky sexual behavior among individuals in residential substance abuse treatment. , 2010, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[124]  S. Mitchell,et al.  Effects of short-term nicotine deprivation on decision-making: delay, uncertainty and effort discounting. , 2004, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[125]  N. Petry,et al.  Delay and probability discounting in pathological gamblers with and without a history of substance use problems , 2011, Psychopharmacology.

[126]  E. Sonuga-Barke,et al.  Hyperactivity and delay aversion--I. The effect of delay on choice. , 1992, Journal of child psychology and psychiatry, and allied disciplines.

[127]  Taiki Takahashi,et al.  Alcohol use and discounting of delayed and probabilistic gain and loss. , 2009, Neuro endocrinology letters.

[128]  J. Gray,et al.  Interrelationships among individual differences in alcohol demand, impulsivity, and alcohol misuse. , 2014, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[129]  W. Mischel,et al.  Delay of gratification in children. , 1989, Science.

[130]  James MacKillop,et al.  Alcohol demand, delayed reward discounting, and craving in relation to drinking and alcohol use disorders. , 2010, Journal of abnormal psychology.

[131]  J. Anker,et al.  Impulsivity predicts the escalation of cocaine self-administration in rats , 2009, Pharmacology Biochemistry and Behavior.

[132]  R. Paxton.  The effects of a deposit contract as a component in a behavioural programme for stopping smoking. , 1980, Behaviour research and therapy.

[133]  C. Winstanley,et al.  Chronic atomoxetine treatment during adolescence decreases impulsive choice, but not impulsive action, in adult rats and alters markers of synaptic plasticity in the orbitofrontal cortex , 2011, Psychopharmacology.

[134]  H. Lando.  Successful treatment of smokers with a broad-spectrum behavioral approach. , 1977, Journal of consulting and clinical psychology.

[135]  Yu-Shin Ding,et al.  Expectation Enhances the Regional Brain Metabolic and the Reinforcing Effects of Stimulants in Cocaine Abusers , 2003, The Journal of Neuroscience.

[136]  J. Schweitzer,et al.  Self-control in boys with attention deficit hyperactivity disorder: effects of added stimulation and time. , 1995, Journal of child psychology and psychiatry, and allied disciplines.

[137]  W. Bickel,et al.  Influence of an alternative reinforcer on human cocaine self-administration. , 1994, Life sciences.

[138]  L. Epstein,et al.  Reinforcing Value of Food in Obese and Non-obese Women , 1996, Appetite.

[139]  R. Thaler.  Some empirical evidence on dynamic inconsistency , 1981 .

[140]  J. E. Mazur,et al.  Choice in a "self-control" paradigm: effects of a fading procedure. , 1978, Journal of the experimental analysis of behavior.

[141]  W. Bickel,et al.  Heroin addicts have higher discount rates for delayed rewards than non-drug-using controls. , 1999 .

[142]  Amy L. Tobler,et al.  Effects of alcohol tax and price policies on morbidity and mortality: a systematic review. , 2010, American journal of public health.

[143]  Matthew W. Johnson,et al.  Delay discounting in current and former marijuana-dependent individuals. , 2010, Experimental and clinical psychopharmacology.

[144]  D. Oslin,et al.  A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent Patients , 2003, Neuropsychopharmacology.

[145]  H. Delaney,et al.  The community reinforcement approach with homeless alcohol-dependent individuals. , 1998, Journal of consulting and clinical psychology.

[146]  P. Samuelson.  A Note on Measurement of Utility , 1937 .

[147]  G. Badger,et al.  Comparison of the frequency and enjoyability of pleasant events in cocaine abusers vs. non-abusers using a standardized behavioral inventory. , 1998, Addiction.

[148]  D. McChargue,et al.  DRD2/ANKK1 TaqI A genotype moderates the relationship between alexithymia and the relative value of alcohol among male college binge drinkers , 2012, Pharmacology Biochemistry and Behavior.

[149]  K. Carey,et al.  Decreased substance use following increases in alternative behaviors: a preliminary investigation. , 2004, Addictive behaviors.

[150]  S. Mitchell,et al.  Measures of impulsivity in cigarette smokers and non-smokers , 1999, Psychopharmacology.

[151]  H. Rachlin.  Notes on discounting. , 2006, Journal of the experimental analysis of behavior.

[152]  T. Wall,et al.  Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians. , 2006, Psychological bulletin.

[153]  W. Bickel,et al.  The combined effects of delay and probability in discounting , 2006, Behavioural Processes.

[154]  Shawn R. Charlton,et al.  Future altruism: Social discounting of delayed rewards , 2011, Behavioural Processes.

[155]  S T Higgins,et al.  Sustained cocaine abstinence in methadone maintenance patients through voucher-based reinforcement therapy. , 1996, Archives of general psychiatry.

[156]  I. Gottesman,et al.  The endophenotype concept in psychiatry: etymology and strategic intentions. , 2003, The American journal of psychiatry.

[157]  A. Odum,et al.  Impulsivity and cigarette smoking: delay discounting in current, never, and ex-smokers , 1999, Psychopharmacology.

[158]  Paul F. Hill,et al.  Remember the Future: Working Memory Training Decreases Delay Discounting Among Stimulant Addicts , 2011, Biological Psychiatry.

[159]  S. Mitchell,et al.  Neuropsychological function and delay discounting in methamphetamine-dependent individuals , 2006, Psychopharmacology.

[160]  N. Petry,et al.  Contingency management treatments decrease psychiatric symptoms. , 2013, Journal of consulting and clinical psychology.

[161]  C. P. Morris,et al.  Behavioral and Brain Functions , 2008 .

[162]  J. Lucas,et al.  Disinhibitory psychopathology and delay discounting in alcohol dependence: personality and cognitive correlates. , 2009, Experimental and clinical psychopharmacology.

[163]  N. Petry,et al.  Combining cognitive behavioral therapy and contingency management to enhance their effects in treating cannabis dependence: less can be more, more or less. , 2012, Addiction.

[164]  J. MacKillop,et al.  Cigarette demand and delayed reward discounting in nicotine-dependent individuals with schizophrenia and controls: an initial study , 2011, Psychopharmacology.

[165]  M. Amlung,et al.  Individual Variation in Behavioral Economic Indices of the Relative Value of Alcohol: Incremental Validity in Relation to Impulsivity, Craving, and Intellectual Functioning , 2012 .

[166]  T. Saxton,et al.  Hyperactivity and delay aversion. III: The effect on cognitive style of imposing delay after errors. , 1996, Journal of child psychology and psychiatry, and allied disciplines.

[167]  Ashley Acheson,et al.  Greater discounting of delayed rewards in young adults with family histories of alcohol and drug use disorders: studies from the Oklahoma family health patterns project. , 2011, Alcoholism, clinical and experimental research.

[168]  W. Bickel,et al.  The Behavioral Economics and Neuroeconomics of Reinforcer Pathologies: Implications for Etiology and Treatment of Addiction , 2011, Current psychiatry reports.

[169]  James MacKillop,et al.  Delayed reward discounting predicts treatment response for heavy drinkers receiving smoking cessation treatment. , 2009, Drug and alcohol dependence.

[170]  F. Chaloupka,et al.  Tobacco taxes as a tobacco control strategy , 2012, Tobacco Control.

[171]  G. Ainslie,et al.  The relationship between addiction and reward bundling: an experiment comparing smokers and non-smokers. , 2011, Addiction.

[172]  Matthew W. Johnson,et al.  Moderate drug use and delay discounting: a comparison of heavy, light, and never smokers. , 2007, Experimental and clinical psychopharmacology.

[173]  Hong Qian,et al.  Statistics and Related Topics in Single-Molecule Biophysics. , 2014, Annual review of statistics and its application.

[174]  James G. Murphy,et al.  The effect of drink price and next-day responsibilities on college student drinking: a behavioral economic analysis. , 2011, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[175]  C. Galuska,et al.  Effects of daily morphine administration and deprivation on choice and demand for remifentanil and cocaine in rhesus monkeys. , 2011, Journal of the experimental analysis of behavior.

[176]  N. Petry,et al.  A randomized study of cellphone technology to reinforce alcohol abstinence in the natural environment. , 2013, Addiction.

[177]  Brady Reynolds,et al.  Delay and probability discounting as related to different stages of adolescent smoking and non-smoking , 2003, Behavioural Processes.

[178]  A. Morral,et al.  Reinforcing operants other than abstinence in drug abuse treatment: an effective alternative for reducing drug use. , 1997, Journal of consulting and clinical psychology.

[179]  M. Le Moal,et al.  Addiction and the brain antireward system. , 2008, Annual review of psychology.

[180]  M. Carroll,et al.  Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake , 2007, Pharmacology Biochemistry and Behavior.

[181]  S. Kollins,et al.  Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review , 2001, Pharmacology Biochemistry and Behavior.

[182]  A. Odum,et al.  Needle sharing in opioid-dependent outpatients: psychological processes underlying risk. , 2000, Drug and alcohol dependence.

[183]  S R Hursh,et al.  Normalized demand for drugs and other reinforcers. , 1995, Journal of the experimental analysis of behavior.

[184]  Christina M. Legierski,et al.  Overweight children find food more reinforcing and consume more energy than do nonoverweight children. , 2008, The American journal of clinical nutrition.

[185]  T. Killeen,et al.  Effectiveness of abstinence-based incentives: interaction with intake stimulant test results. , 2007, Journal of consulting and clinical psychology.

[186]  G. Birchler,et al.  Brief relationship therapy for alcoholism: a randomized clinical trial examining clinical efficacy and cost-effectiveness. , 2005, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[187]  L. Epstein,et al.  Food reinforcement, the dopamine D2 receptor genotype, and energy intake in obese and nonobese humans. , 2007, Behavioral neuroscience.

[188]  L. Epstein,et al.  Food reinforcement, energy intake, and macronutrient choice. , 2011, The American journal of clinical nutrition.

[189]  L. Hogarth,et al.  Isolating behavioural economic indices of demand in relation to nicotine dependence , 2012, Psychopharmacology.

[190]  Mark A. R. Kleiman,et al.  When Brute Force Fails: How to Have Less Crime and Less Punishment , 2009 .

[191]  B. Rounsaville,et al.  One-year follow-up of psychotherapy and pharmacotherapy for cocaine dependence. Delayed emergence of psychotherapy effects. , 1994, Archives of general psychiatry.

[192]  B. Reynolds.  The Experiential Discounting Task is sensitive to cigarette-smoking status and correlates with a measure of delay discounting , 2006, Behavioural pharmacology.

[193]  H Rachlin,et al.  Commitment, choice and self-control. , 1972, Journal of the experimental analysis of behavior.

[194]  W. G. Johnson.  Effect of cue prominence and subject weight on human food-directed performance. , 1974, Journal of personality and social psychology.

[195]  Cristina B. Gibson,et al.  Where Global and Virtual Meet: The Value of Examining the Intersection of These Elements in Twenty-First-Century Teams , 2014 .

[196]  K. Kiehl,et al.  Neural and behavioral mechanisms of impulsive choice in alcohol use disorder. , 2011, Alcoholism, clinical and experimental research.

[197]  Steven R. Hursh,et al.  Demand for cocaine and food over time , 2008, Pharmacology Biochemistry and Behavior.

[198]  Mitul A Mehta,et al.  DAT1 and COMT Effects on Delay Discounting and Trait Impulsivity in Male Adolescents with Attention Deficit/Hyperactivity Disorder and Healthy Controls , 2010, Neuropsychopharmacology.

[199]  D. Couper,et al.  An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. , 2008, Archives of general psychiatry.

[200]  R. Winett.  Parameters of Deposit Contracts in the Modification of Smoking , 1973 .

[201]  W. Miller,et al.  Meeting in the middle: motivational interviewing and self-determination theory , 2012, International Journal of Behavioral Nutrition and Physical Activity.

[202]  R. Herrnstein.  On the law of effect. , 1970, Journal of the experimental analysis of behavior.

[203]  W. Bickel,et al.  Altruism in time: social temporal discounting differentiates smokers from problem drinkers , 2012, Psychopharmacology.

[204]  B. Alexander,et al.  The effect of housing and gender on preference for morphine-sucrose solutions in rats , 2004, Psychopharmacology.

[205]  S. Mitchell,et al.  Gender differences in factors associated with alcohol drinking: delay discounting and perception of others' drinking. , 2012, Drug and alcohol dependence.

[206]  S. L. Huskinson,et al.  Strain differences in delay discounting between Lewis and Fischer 344 rats at baseline and following acute and chronic administration of d-amphetamine , 2012, Pharmacology Biochemistry and Behavior.

[207]  M. F. Triplett,et al.  Test-retest reliability of a group-administered paper-pencil measure of delay discounting. , 2009, Experimental and clinical psychopharmacology.

[208]  Matthew W. Johnson,et al.  The Effects of Reduced Cigarette Smoking on Discounting Future Rewards: An Initial Evaluation , 2008, The Psychological record.

[209]  B. Borsari,et al.  A randomized controlled trial of a behavioral economic supplement to brief motivational interventions for college drinking. , 2012, Journal of consulting and clinical psychology.

[210]  Derrik R. Tollefson,et al.  A Meta-Analysis of Motivational Interviewing: Twenty-Five Years of Empirical Studies , 2010 .

[211]  J. Buscemi,et al.  Reinforcing efficacy moderates the relationship between impulsivity-related traits and alcohol use. , 2010, Experimental and clinical psychopharmacology.

[212]  G. Loewenstein,et al.  Time Discounting and Time Preference: A Critical Review , 2002 .

[213]  J. MacKillop,et al.  Symptoms of depression and PTSD are associated with elevated alcohol demand. , 2013, Drug and alcohol dependence.

[214]  G. Badger,et al.  Abstinence-contingent reinforcement and engagement in non-drug-related activities among illicit drug abusers. , 2008, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[215]  G. Badger,et al.  Comparison of the subjective, physiological, and psychomotor effects of atomoxetine and methylphenidate in light drug users. , 2002, Drug and alcohol dependence.

[216]  R. Herrnstein,et al.  Choice and delay of reinforcement. , 1967, Journal of the experimental analysis of behavior.

[217]  M. Munafo,et al.  Delayed reward discounting and addictive behavior: a meta-analysis , 2011, Psychopharmacology.

[218]  B. Reynolds.  A review of delay-discounting research with humans: relations to drug use and gambling , 2006, Behavioural pharmacology.

[219]  K. Cosgrove,et al.  Wheel-running attenuates intravenous cocaine self-administration in rats Sex differences , 2002, Pharmacology Biochemistry and Behavior.

[220]  L. Ray,et al.  Naltrexone for the treatment of alcoholism: clinical findings, mechanisms of action, and pharmacogenetics. , 2010, CNS & neurological disorders drug targets.

[221]  K. Carey,et al.  Predicting drug use: application of behavioral theories of choice. , 1998, Addictive behaviors.

[222]  L. Epstein,et al.  Food hedonics and reinforcement as determinants of laboratory food intake in smokers , 2004, Physiology & Behavior.

[223]  L. Epstein,et al.  Food reinforcement and impulsivity in overweight children and their parents. , 2008, Eating behaviors.

[224]  Noah A. Shamosh,et al.  Individual Differences in Delay Discounting , 2008, Psychological science.

[225]  B. Reynolds.  Do high rates of cigarette consumption increase delay discounting? A cross-sectional comparison of adolescent smokers and young-adult smokers and nonsmokers , 2004, Behavioural Processes.

[226]  R. Vuchinich,et al.  Alcoholic relapse, life events, and behavioral theories of choice: A prospective analysis. , 1996 .

[227]  James W. Diller,et al.  Temporal discounting and heart rate reactivity to stress , 2011, Behavioural Processes.

[228]  G. Badger,et al.  Effects of adding behavioral treatment to opioid detoxification with buprenorphine. , 1997, Journal of consulting and clinical psychology.

[229]  Mikhail N. Koffarnus,et al.  A randomized clinical trial of a Therapeutic Workplace for chronically unemployed, homeless, alcohol-dependent adults. , 2011, Alcohol and alcoholism.

[230]  L. Few,et al.  Temporal stability of a cigarette purchase task. , 2012, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[231]  W M Baum,et al.  Choice as time allocation. , 1969, Journal of the experimental analysis of behavior.

[232]  G. Koob,et al.  What is addiction? , 2019, Introduction to Addiction.

[233]  H. Rachlin.  Four teleological theories of addiction , 1997 .

[234]  J. Richards,et al.  Acute Administration of d-Amphetamine Decreases Impulsivity in Healthy Volunteers , 2002, Neuropsychopharmacology.

[235]  Kevin G Volpp,et al.  Financial incentive-based approaches for weight loss: a randomized trial. , 2008, JAMA.

[236]  N. Petry,et al.  Delay discounting of money and alcohol in actively using alcoholics, currently abstinent alcoholics, and controls , 2001, Psychopharmacology.

[237]  P. Postmus,et al.  Effects on Smoking Cessation: Naltrexone Combined with a Cognitive Behavioral Treatment Based on the Community Reinforcement Approach , 2006, Substance use & misuse.

[238]  D. Jeste,et al.  A review of cognitive training in schizophrenia. , 2003, Schizophrenia bulletin.

[239]  W. Bickel,et al.  Behavioral economics: a novel experimental approach to the study of drug dependence. , 1993, Drug and alcohol dependence.

[240]  G. Birchler,et al.  Behavioral Couples Therapy for Substance Abuse: Rationale, Methods, and Findings , 2004, Science & practice perspectives.

[241]  Alan J Budney,et al.  Delay discounting predicts adolescent substance abuse treatment outcome. , 2012, Experimental and clinical psychopharmacology.

[242]  George Ainslie,et al.  Frontoparietal cortical activity of methamphetamine‐dependent and comparison subjects performing a delay discounting task , 2007, Human brain mapping.

[243]  N. Petry,et al.  Give them prizes, and they will come: contingency management for treatment of alcohol dependence. , 2000, Journal of consulting and clinical psychology.

[244]  Zeb Kurth-Nelson,et al.  Single- and cross-commodity discounting among cocaine addicts: the commodity and its temporal location determine discounting rate , 2011, Psychopharmacology.

[245]  N. Petry,et al.  The cost-effectiveness of prize-based and voucher-based contingency management in a population of cocaine- or opioid-dependent outpatients. , 2009, Drug and alcohol dependence.

[246]  R J HERRNSTEIN,et al.  Relative and absolute strength of response as a function of frequency of reinforcement. , 1961, Journal of the experimental analysis of behavior.

[247]  Taiki Takahashi,et al.  Three-month stability of delay and probability discounting measures. , 2006, Experimental and clinical psychopharmacology.

[248]  Rudolf N. Cardinal,et al.  Neural systems implicated in delayed and probabilistic reinforcement , 2006, Neural Networks.

[249]  K. Hutchison,et al.  GENETIC STUDY: Do genetic and individual risk factors moderate the efficacy of motivational enhancement therapy? Drinking outcomes with an emerging adult sample , 2009, Addiction biology.

[250]  Jeffrey P. Cohen,et al.  Health-care service utilization in substance abusers receiving contingency management and standard care treatments. , 2012, Addiction.

[251]  I. Kawachi,et al.  Giving means receiving: the protective effect of social capital on binge drinking on college campuses. , 2000, American journal of public health.

[252]  Bryan Hartzler,et al.  Contingency management in substance abuse treatment: a structured review of the evidence for its transportability. , 2012, Drug and alcohol dependence.

[253]  M. Roesch,et al.  Previous Cocaine Exposure Makes Rats Hypersensitive to Both Delay and Reward Magnitude , 2007, The Journal of Neuroscience.

[254]  J. Tucker,et al.  Behavioral economic analysis of natural resolution of drinking problems using IVR self-monitoring. , 2008, Experimental and clinical psychopharmacology.

[255]  S R Hursh,et al.  Relative Reinforcing Effects of Cocaine, Remifentanil, and Their Combination in Rhesus Monkeys , 2006, Journal of Pharmacology and Experimental Therapeutics.

[256]  J. McGeary,et al.  The Role of Genetics in Nicotine Dependence: Mapping the Pathways from Genome to Syndrome , 2010 .

[257]  Dardo Tomasi,et al.  Addiction circuitry in the human brain. , 2012, Annual review of pharmacology and toxicology.

[258]  David Goldman,et al.  The genetics of addictions: uncovering the genes , 2005, Nature Reviews Genetics.

[259]  G. Madden,et al.  Impulsivity: The Behavioral and Neurological Science of Discounting , 2010 .

[260]  Rodney J. Moore,et al.  Abuse liability assessment of atomoxetine in a drug-abusing population. , 2008, Drug and alcohol dependence.

[261]  L. Ray,et al.  A polymorphism of the mu-opioid receptor gene (OPRM1) and sensitivity to the effects of alcohol in humans. , 2004, Alcoholism, clinical and experimental research.

[262]  H. Rachlin,et al.  Soft commitment: self-control achieved by response persistence. , 1995, Journal of the experimental analysis of behavior.

[263]  Samuel M. McClure,et al.  Separate Neural Systems Value Immediate and Delayed Monetary Rewards , 2004, Science.

[264]  J. Dallery,et al.  Effects of acute and chronic nicotine on impulsive choice in rats , 2005, Behavioural pharmacology.

[265]  Leslie K. John,et al.  Financial Incentives for Extended Weight Loss: A Randomized, Controlled Trial , 2011, Journal of General Internal Medicine.

[266]  J. E. Mazur.  An adjusting procedure for studying delayed reinforcement. , 1987 .

[267]  R. Winett,et al.  Nicotine fading, behavioral contracting, and extended treatment: effects on smoking cessation. , 1987, Addictive behaviors.

[268]  L. Fields,et al.  Varieties of Stimulus Control in Matching-to-Sample: A Kernel Analysis , 2010 .

[269]  J. MacKillop,et al.  Relative reinforcing efficacy of alcohol among college student drinkers. , 2006, Experimental and clinical psychopharmacology.

[270]  R. Vuchinich,et al.  Contributions from behavioral theories of choice to an analysis of alcohol abuse. , 1988, Journal of abnormal psychology.

[271]  D. Cross,et al.  Subjective probability and delay. , 1991, Journal of the experimental analysis of behavior.

[272]  D. Oslin,et al.  A mu opioid receptor gene polymorphism (A118G) and naltrexone treatment response in adherent Korean alcohol-dependent patients , 2008, Psychopharmacology.