Deposition of inhaled aerosols.

The development of theoretical models and the experimental studies that have been done describe the deposition of aerosols in the respiratory tract as a function of particle size and respiration patterns. Descriptions of the anatomical structure of the respiratory tract, air flows, and the physical behavior of airborne particles illustrate the basis of the various models of inhaled particle deposition. Particle density, shape, hygroscopicity, and pathology influence particle deposition, and the particle size distribution and deposition site of the inhaled aerosol influence the resultant biological response.

[1]  Dennis Wl.  The effect of breathing rate on the deposition of particles in the human respiratory system. , 1970 .

[2]  V. Lamer,et al.  The retention of aerosol particles in the human respiratory tract as a function of particle radius. , 1948, The Journal of industrial hygiene and toxicology.

[3]  N. Nelson,et al.  ESTIMATION OF LUNG TISSUE DOSE FROM THE INHALATION OF RADON AND DAUGHTERS. , 1964, Health physics.

[4]  C. Harrison,et al.  The Action of Flint of Variable Size Injected at Constant Weight and Constant Surface into the Lungs of Rats , 1953, British journal of industrial medicine.

[5]  J. M. Dallavalle,et al.  Chronic Manganese Poisoning in an Ore-Crushing Mill. , 1940 .

[6]  W. J. Bair,et al.  PLUTONIUM PARTICLE-INDUCED NEOPLASIA OF THE CANINE LUNG. II. HISTOPATHOLOGY AND CONCLUSIONS , 1965 .

[7]  G. Green.  Integrated defense mechanisms in models of chronic pulmonary disease. , 1970, Archives of internal medicine.

[8]  J. Heyder,et al.  The breathing of half micron aerosols—III dispersion of particles in the respiratory tract , 1971 .

[9]  B. Altshuler.  Calculation of regional deposition of aerosol in the respiratory tract , 1959 .

[10]  D. K. Craig,et al.  Alveolar deposition of 239 PuO 2 aerosols in beagle dogs as a function of respiration and aerosol parameters. , 1972, Health physics.

[11]  M. Lippmann,et al.  The regional deposition of inhaled aerosols in man. , 1970, Inhaled particles.

[12]  A. J. Ihde.  Agricola on metals , 1959 .

[13]  H. Patterson,et al.  The Percentage of Particles of Different Sizes Removed from Dust-Laden Air by Breathing. , 1940 .

[14]  Hatch Tf,et al.  Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics. , 1966 .

[15]  W. J. Bair,et al.  ACUTE AND CHRONIC EFFECTS OF INHALED 144CEO2 IN DOGS. , 1964, Health physics.

[16]  D. W. Henderson,et al.  Studies on respiratory infection: II. The influence of aerosol particle size on infection of the guinea-pig with Pasteurella pestis , 1956, Journal of Hygiene.

[17]  A. George,et al.  RESPIRATORY TRACT DEPOSITION OF RADON DAUGHTERS IN HUMANS EXPOSED IN A URANIUM MINE (PHASE II). , 1970 .

[18]  C. N. Davies.  Inhalation Risk and Particle Size in Dust and Mist* , 1949, British journal of industrial medicine.

[19]  R. Mccallum,et al.  The lead hazard in shipbreaking: The prevalence of anaemia in burners. , 1968, The Annals of occupational hygiene.

[20]  P. Morrow.  Some physical and physiological factors controlling the fate of inhaled substances. I. Deposition. , 1960, Health physics.

[21]  T. Plotkin,et al.  Air flow measurements on human subjects with and without respiratory resistance at several work rates. , 1951, A.M.A. archives of industrial hygiene and occupational medicine.

[22]  D. W. Henderson,et al.  Studies on respiratory infection: I. The influence of particle size on respiratory infection with anthrax spores , 1953, Journal of Hygiene.

[23]  J. Duguid,et al.  The size and the duration of air-carriage of respiratory droplets and droplet-nuclei , 1946, Epidemiology and Infection.

[24]  Heinrich v. Hayek,et al.  The human lung , 1960 .

[25]  C. E. Brown.  Quantitative Measurements of the Inhalation, Retention, and Exhalation of Dusts and Fumes by Man : II. Concentrations below 50 mg. per Cubic Meter. , 1931 .

[26]  V. Timbrell,et al.  The effect of shape on particle penetration and retention in animal lungs. , 1970, Inhaled particles.

[27]  T. Hatch,et al.  Influence of Particle Size upon the Retention of Particulate Matter in the Human Lung. , 1950, American journal of public health and the nation's health.

[28]  C N DAVIES.  DEPOSITION AND RETENTION OF DUST IN THE HUMAN RESPIRATORY TRACT. , 1964, The Annals of occupational hygiene.

[29]  E. Weibel.  Morphometry of the Human Lung , 1965, Springer Berlin Heidelberg.

[30]  H. M. Parker.  The dilemma of lung dosimetry. , 1969, Health physics.

[31]  R. V. Lourenço.  Distribution and clearance of aerosols , 1969 .

[32]  P. Dean,et al.  Tumorigenicity of small highly radioactive particles. , 1969, Health physics.

[33]  H. Landahl,et al.  On the retention of airborne particulates in the human lung: II. , 1951, A.M.A. archives of industrial hygiene and occupational medicine.

[34]  P. Morrow,et al.  EVALUATION OF INHALATION HAZARDS BASED UPON THE RESPIRABLE DUST CONCEPT AND THE PHILOSOPHY AND APPLICATION OF SELECTIVE SAMPLING. , 1964, American Industrial Hygiene Association journal.

[35]  L. Casarett.  Some physical and physiological factors controlling the fate of inhaled substances. II. Retention. , 1960, Health physics.

[36]  V. K. Mer,et al.  Light scattering as a measure of particle size in aerosols; the production of monodisperse aerosols. , 1949, Chemical reviews.

[37]  E. Palmes,et al.  Intrapulmonary mixing of gases studied with aerosols. , 1959, Journal of applied physiology.

[38]  M Lippmann,et al.  The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. , 1969, American Industrial Hygiene Association journal.

[39]  L. U. Gardner,et al.  The Reaction to Fine and Medium Sized Quartz and Aluminum Oxide Particles. Silicotic Cirrhosis of the Liver. , 1933, The American journal of pathology.

[40]  E. Cunningham.  On the Velocity of Steady Fall of Spherical Particles through Fluid Medium , 1910 .

[41]  T. Hatch,et al.  Influence of particle size in dust exposure. , 1948, The Journal of industrial hygiene and toxicology.

[42]  H. Landahl.  Particle removal by the respiratory system note on the removal of airborne particulates by the human respiratory tract with particular reference to the role of diffusion. , 1963, The Bulletin of mathematical biophysics.

[43]  R. J. Goodlow,et al.  VIABILITY AND INFECTIVITY OF MICROORGANISMS IN EXPERIMENTAL AIRBORNE INFECTION , 1961, Bacteriological reviews.

[44]  E. Palmes,et al.  Effect of chronic obstructive pulmonary disease on rate of deposition of aerosols in the lung during breath holding. , 1970, Inhaled particles.

[45]  A Black,et al.  Deposition of aerosol particles in the nasopharyngeal region of the human respiratory tract. , 1971, Nature.

[46]  H. Landahl,et al.  Penetration of air-borne particulates through the human nose. , 1949, The Journal of industrial hygiene and toxicology.

[47]  T. Hatch,et al.  Pulmonary Deposition and Retention of Inhaled Aerosols , 1964 .

[48]  David C.F. Muir,et al.  The Deposition of 0·5 µ Diameter Aerosols in the Lungs of Man , 1967 .

[49]  C. Davies,et al.  Definitive equations for the fluid resistance of spheres , 1945 .

[50]  E. Goldstein,et al.  The effect of silicosis on the antibacterial defense mechanisms of the murine lung. , 1969, The Journal of infectious diseases.

[51]  J. Beeckmans.  THE DEPOSITION OF AEROSOLS IN THE RESPIRATORY TRACT. I. MATHEMATICAL ANALYSIS AND COMPARISON WITH EXPERIMENTAL DATA. , 1966, Canadian journal of physiology and pharmacology.

[52]  H. Landahl.  On the removal of air-borne droplets by the human respiratory tract: II. The nasal passages , 1950 .

[53]  H. Landahl.  On the removal of air-borne droplets by the human respiratory tract: I. The lung , 1950 .

[54]  E. Palmes,et al.  REGIONAL AEROSOL DEPOSITION IN THE HUMAN RESPIRATORY TRACT , 1967 .

[55]  Studies on respiratory infection. III. Experiments with Brucella suis. , 1956, The Journal of hygiene.

[56]  Dust Sampling to Simulate the Human Lung , 1953, British journal of industrial medicine.

[57]  C. Davies.  Inhaled Particles and Vapours , 1960 .

[58]  E. Palmes,et al.  DEPOSITION OF AEROSOLS IN THE HUMAN RESPIRATORY TRACT DURING BREATH HOLDING , 1967 .

[59]  W. J. Bair,et al.  Plutonium inhalation studies. III. Effect of particle size and total dose on deposition, retention and translocation. , 1963, Health physics.

[60]  Mercer Tt.  On the role of particle size in the dissolution of lung burdens. , 1967 .

[61]  W. Jacobi.  THE DOSE TO THE HUMAN RESPIRATORY TRACT BY INHALATION OF SHORT-LIVED 222RN- AND 220RN-DECAY PRODUCTS. , 1964, Health physics.